ANXA1 and HSPB1

Number of citations of the paper that reports this interaction (PubMedID 25277244)
81

Data Source:
BioGRID (two hybrid)

		ANXA1	HSPB1
Description		annexin A1	heat shock protein family B (small) member 1
Image
GO Annotations	Cellular Component	Cornified Envelope Phagocytic Cup Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Actin Filament Plasma Membrane Adherens Junction Focal Adhesion Cilium Cell Surface Endosome Membrane Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Motile Cilium Early Endosome Membrane Vesicle Sarcolemma Cell Projection Extracellular Exosome	Proteasome Complex Cornified Envelope Extracellular Space Nucleus Cytoplasm Spindle Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Z Disc Contractile Muscle Fiber Extracellular Exosome Axon Cytoplasm
	Molecular Function	Phosphatidylserine Binding Phospholipase Inhibitor Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Lipid Binding Phospholipase A2 Inhibitor Activity Metal Ion Binding Calcium-dependent Protein Binding Cadherin Binding Involved In Cell-cell Adhesion	RNA Binding Protein Kinase C Binding Protein Binding Protein Kinase C Inhibitor Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Protein Folding Chaperone Unfolded Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Neutrophil Homeostasis Adaptive Immune Response Immune System Process Monocyte Chemotaxis Regulation Of Leukocyte Migration Phagocytosis Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Cell Shape Myoblast Migration Involved In Skeletal Muscle Regeneration Peptide Cross-linking Actin Cytoskeleton Organization Keratinocyte Differentiation Positive Regulation Of Vesicle Fusion Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-8 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Neutrophil Apoptotic Process Cellular Response To Vascular Endothelial Growth Factor Stimulus Positive Regulation Of T Cell Proliferation Neutrophil Activation Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Exocytosis Alpha-beta T Cell Differentiation Regulation Of Hormone Secretion Arachidonate Secretion Regulation Of Inflammatory Response Negative Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Cellular Response To Glucocorticoid Stimulus Granulocyte Chemotaxis Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Wound Healing Neutrophil Clearance Cell-cell Adhesion Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle	Regulation Of Protein Phosphorylation Regulation Of Translational Initiation Protein Folding Response To Unfolded Protein Response To Heat Response To Virus Regulation Of Autophagy Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Cellular Response To Vascular Endothelial Growth Factor Stimulus Protein Refolding Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Platelet Aggregation Negative Regulation Of Protein Kinase C Signaling Anterograde Axonal Protein Transport Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Endothelial Cell Chemotaxis Negative Regulation Of Apoptotic Signaling Pathway
Pathways		G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands Smooth Muscle Contraction Interleukin-4 and Interleukin-13 signaling Developmental Lineage of Pancreatic Ductal Cells	VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling
Drugs		Amcinonide Fluocinolone acetonide Hydrocortisone Methylprednisolone Clobetasol propionate Budesonide Dexamethasone Cortisone acetate Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate Prednisolone phosphate Dexamethasone acetate Betamethasone phosphate	Apatorsen Artenimol Phenethyl Isothiocyanate
Diseases			Distal hereditary motor neuropathies (dHMN)
GWAS		Chronotype ( 30696823) Cortical surface area ( 32963231) Cortical volume ( 32963231) Metabolite levels ( 23823483) Parkinson's disease ( 26227905) Schizophrenia, bipolar disorder and depression (combined) ( 20713499) Urate levels in obese individuals ( 25811787)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Schizophrenia ( 30285260)
Interacting Genes		80 interacting genes: AP2A2 APBB1 BUB3 CCN1 CCT7 CD274 CD44 CDC5L CDH13 CLIC1 CLTC COPS6 CORO1C CSAD CZIB DAPK3 DDB1 DDX3X DYSF EEF2 EGFR EIF2S1 EPHA2 ERG28 FAF1 FGFBP1 FLOT1 FLOT2 FPR1 G3BP2 GAPDH GAPDHS GNL3 HMGA1 HSP90AB1 HSPB1 IFIT1 IFIT3 IGF2BP1 IGF2BP3 KLHL23 KMT2B KRT8 LGALS3 LGALS8 LMNA LMO7 LNPK LRIF1 MEIS2 MEN1 MYBBP1A MYH10 MYH9 NOP58 OTUB1 PARP1 PARP9 PHB2 PRKCI RCC2 S100A11 SRC STRAP SUMO2 TCP1 TGM2 TOE1 TRAF4 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UGDH UNC119 USP7 XRCC1 XRCC6 YWHAQ	248 interacting genes: ACAP2 ACBD6 ACTC1 ACTN1 ACTN2 ACTN4 ADCY9 ADD3 ADPRS AGAP10P AGAP3 AGAP4 AGAP5 AGAP7P AKT1 ALPI AMD1 ANAPC7 ANK1 ANKRD7 ANXA1 AP2B1 APPL1 ARHGAP28 ARHGEF7 ARIH1 ARRDC5 ATXN10 BICDL1 C11orf98 CAMK1 CBX1 CCDC32 CCDC70 CCHCR1 CCNC CCNDBP1 CCNO CDK5RAP3 CENPK CEP78 CETN3 CFAP251 CIMIP6 CLCN3 CPSF3 CRNKL1 CRYAA CRYAB CRYBB2 CRYGC CS CYCS DAXX DCPH1 DES DMAP1 DNAJC21 ECPAS EHD1 EIF1AX EIF2S1 EIF3M EIF4G1 EIF4G3 EIF5 ENPP2 EPB41L1 EPB41L2 EPB41L3 ERCC5 ERICH6 ESR1 FLNB FNDC3B FOXP1 FXR1 FXR2 GAPVD1 GARIN2 GDI2 GLMN GNPAT GOLGA8A GRIPAP1 GRK3 GSTO1 GTSF1 GUCA1A HAUS8 HDLBP HNRNPD HNRNPU HSP90AB1 HSPA4 HSPB8 IARS2 IGBP1 IGSF21 INPP5K INS ISG20L2 KANSL1 KCMF1 KCTD3 KLC1 KNSTRN KPNA3 KRT18 KRT72 LBP LIG1 LONRF1 LRIF1 LSM3 LUZP1 MAPK14 MAPKAPK2 MAPKAPK3 MAPKAPK5 MCM6 MDH2 MED31 MFAP1 MPHOSPH6 MRGBP MRPL28 MRPL40 MRPS23 MSL1 MTIF2 MYG1 MYL12A MYL12B MYL9 MYLK NAP1L1 NAPA NBAS NCKIPSD NEK10 NEXN NFKBIA NFU1 NSMCE4A NVL OBSL1 OPTN OSBPL9 PAF1 PALM3 PELO PGM2 PHYHIPL PLG PNISR PNPT1 POP7 POPDC1 PPA1 PPM1A PPP2R3C PRPF19 PRPF40A PSMA3 PSMA6 PSMB2 PSMC1 PSMD1 PTGES3 PTPN3 PTPRA RAB41 RAD23A RALA RASSF9 RBM25 RBM48 RBPJ RPAP3 RPSA RSPH3 RYBP S100A4 SAT1 SBF1 SEC13 SERTAD1 SF3A3 SF3B3 SLC26A4-AS1 SLC7A9 SLC9D1 SMARCA2 SMARCA4 SMARCD1 SNRNP200 SNRPF SPACA7 SPATA7 SPIN1 SPTBN1 SRP72 STUB1 SUMO2 SUPT5H SYCE1 TARBP2 TARS1 TBC1D1 TBC1D3B TGFB1I1 TGM1 THOC5 TJP2 TOMM70 TOX4 TP53 TPT1 TRIM24 TRIM54 TRIM63 TSNAXIP1 TTC3 TTC39C TXNL1 UCHL5 UFD1 UQCC2 UQCRB VIM WASHC3 WDR83 WEE2-AS1 WWP1 XPO1 XRCC5 YWHAB YWHAE YWHAH YWHAQ YWHAZ ZBTB17 ZBTB37 ZFAT ZNF131 ZNF197 ZNRF3
Entrez ID		301	3315
HPRD ID		01060	09076
Ensembl ID		ENSG00000135046	ENSG00000106211
Uniprot IDs		P04083 Q5TZZ9	P04792 V9HW43
PDB IDs		1AIN 1BO9 1QLS 5VFW	2N3J 3Q9P 3Q9Q 4MJH 6DV5 6GJH
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Focal Adhesion Negative Regulation Of Macromolecule Metabolic Process Regulation Of Telomere Maintenance Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Cytosol Nucleus RNA Binding Positive Regulation Of Protein Localization Negative Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Extracellular Exosome MRNA 5'-UTR Binding Positive Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Chromosome Organization Regulation Of Protein Modification Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Process Regulation Of DNA Metabolic Process Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Cell Adhesion Perinuclear Region Of Cytoplasm Biological Process Involved In Interaction With Host Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Negative Regulation Of Macromolecule Biosynthetic Process Signal Transduction Cellular Response To Stress Negative Regulation Of Biosynthetic Process Regulation Of Signal Transduction Positive Regulation Of Nucleobase-containing Compound Metabolic Process Lamellipodium Negative Regulation Of Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Response To Stress Regulation Of Gene Expression Disordered Domain Specific Binding Flotillin Complex Protein Binding	Cytosol RNA Binding Cytoplasm Nucleus Z Disc Nucleoplasm Translational Initiation Protein-RNA Complex Assembly Proteasome Complex Cytoskeletal Protein Binding Catalytic Step 2 Spliceosome Translation Initiation Factor Activity Positive Regulation Of Biosynthetic Process Protein-containing Complex Assembly Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Catabolic Process Structural Constituent Of Eye Lens Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cellular Component Assembly Nuclear Matrix Positive Regulation Of Metabolic Process Intracellular Protein Localization Regulation Of Cellular Localization Protein-containing Complex Organization M Band Regulation Of Telomere Maintenance Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Heat Regulation Of Intracellular Transport Cellular Response To Topologically Incorrect Protein Focal Adhesion Positive Regulation Of RNA Metabolic Process Telomerase Holoenzyme Complex Assembly Phosphoserine Residue Binding Calcium-dependent Protein Serine/threonine Kinase Activity Protein Localization To Organelle Regulation Of Chromosome Organization Glutamatergic Synapse Regulation Of Cell Cycle Spliceosomal Complex MRNA Metabolic Process MRNA Processing U2-type Precatalytic Spliceosome Protein Folding Chaperone Complex Positive Regulation Of Translation Stress-induced Premature Senescence Myosin Heavy Chain Binding Organelle Organization Identical Protein Binding
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