ANXA1 and FAF1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ANXA1	FAF1
Gene Name		annexin A1	Fas (TNFRSF6) associated factor 1
Image
Gene Ontology Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Cytosol CD95 Death-inducing Signaling Complex Cdc48p-Npl4p-Ufd1p AAA ATPase Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Protein Binding Protein Kinase Regulator Activity Protein Kinase Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding NF-kappaB Binding
	Biological Process	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion	Apoptotic Process Cytoplasmic Sequestering Of NF-kappaB Cell Death Regulation Of Cell Adhesion Positive Regulation Of Protein Complex Assembly Regulation Of Protein Catabolic Process Positive Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events
Drugs		Amcinonide Hydrocortisone Dexamethasone
Diseases
GWAS		Schizophrenia, bipolar disorder and depression (combined) ( 20713499)	Depression and alcohol dependence ( 22064162) Ventricular conduction ( 21076409)
Protein-Protein Interactions		31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ	37 interactors: ANXA1 ANXA7 ASCC2 CASP8 CD40 CDC73 CDKN1A CSNK2A1 CSNK2B DNAJB11 FADD FAF2 FAS HSD17B10 IGF2 IKBKB ITGB1BP1 NGLY1 NLRP12 NLRP2 NLRP3 NLRP7 NR1H2 NR4A1 RAP1A RAP1B RCC1 RELA SIRT6 SKIL SNIP1 TAF1D TK1 TNNT1 TSC22D1 UROD VAPB
Entrez ID		301	11124
HPRD ID		01060	05124
Ensembl ID		ENSG00000135046	ENSG00000185104
Uniprot IDs		P04083 Q5TZZ9	B4DEJ6 Q9UNN5
PDB IDs		1AIN 1BO9 1QLS	1H8C 2DZM 2EC4 3E21 3QC8 3QCA 3QQ8 3QWZ 3QX1 3R3M
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Response To Organic Substance Cellular Response To Organic Substance Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Catalytic Activity Response To Organic Cyclic Compound Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Hydrolase Activity Response To Lipid Regulation Of Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Steroid Hormone Positive Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Establishment Of Protein Localization Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Endopeptidase Activity Signal Transduction Regulation Of Signaling Positive Regulation Of Peptidase Activity Regulation Of Endopeptidase Activity Cellular Response To Mechanical Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Peptidase Activity Response To External Stimulus Regulation Of Protein Localization Regulation Of Cellular Localization Leukocyte Homeostasis Regulation Of Immune System Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Protein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Signaling Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Protein Kinase Activity Cell Communication Intracellular Receptor Signaling Pathway
Tagcloud ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Difference) ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	agr apo avian caenorhabditis carboxy conjugating delimited e0 elegans executed fas fibroblast helical homologies homologue mesoderm mutagenesis pluripotent portion potentiates qfaf quail remarkable resides shares transducing ubiquitous unusual
Tagcloud (Intersection) ?