ANXA1 and CSAD

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		ANXA1	CSAD
Gene Name		annexin A1	cysteine sulfinic acid decarboxylase
Image
Gene Ontology Annotations	Cellular Component	Cornified Envelope Extracellular Region Extracellular Space Nucleus Cytoplasm Endosome Plasma Membrane Focal Adhesion Cilium Cell Surface Basolateral Plasma Membrane Mitochondrial Membrane Vesicle Sarcolemma Mast Cell Granule Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Single-stranded DNA Binding Single-stranded RNA Binding Helicase Activity Receptor Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Phospholipase A2 Inhibitor Activity Protein Binding, Bridging Double-stranded DNA-dependent ATPase Activity Annealing Helicase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding	Sulfinoalanine Decarboxylase Activity Pyridoxal Phosphate Binding
	Biological Process	DNA Strand Renaturation Neutrophil Homeostasis Movement Of Cell Or Subcellular Component Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Response To X-ray Peptide Cross-linking Insulin Secretion Keratinocyte Differentiation Prostate Gland Development Endocrine Pancreas Development Positive Regulation Of Vesicle Fusion Positive Regulation Of Prostaglandin Biosynthetic Process Response To Estradiol DNA Duplex Unwinding Positive Regulation Of Neutrophil Apoptotic Process DNA Rewinding Gliogenesis Regulation Of Cell Proliferation Response To Drug Negative Regulation Of Apoptotic Process Response To Peptide Hormone Alpha-beta T Cell Differentiation Arachidonic Acid Secretion Cellular Response To Hydrogen Peroxide Hepatocyte Differentiation Prolactin Secretion Response To Interleukin-1 Cellular Response To Glucocorticoid Stimulus Neutrophil Clearance Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Phospholipase A2 Activity Negative Regulation Of Interleukin-8 Secretion	Sulfur Amino Acid Metabolic Process Sulfur Amino Acid Catabolic Process Cellular Nitrogen Compound Metabolic Process Taurine Biosynthetic Process Small Molecule Metabolic Process
Pathways		G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Formyl peptide receptors bind formyl peptides and many other ligands G alpha (q) signalling events GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK G alpha (i) signalling events	Degradation of cysteine and homocysteine Sulfur amino acid metabolism Metabolism of amino acids and derivatives
Drugs		Amcinonide Hydrocortisone Dexamethasone	Pyridoxal Phosphate L-Cysteine
Diseases
GWAS		Schizophrenia, bipolar disorder and depression (combined) ( 20713499)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		31 interactors: APBB1 C14orf1 C1orf123 CCT7 COPS6 CSAD DYSF EGFR FAF1 FPR1 GAPDH HMGA1 KLHL23 KMT2B KRT8 LRIF1 MEIS2 OTUB1 PRKCI RPA1 S100A11 SRC TGM2 TRPM7 UBE2D1 UBE2I UBE3A UCHL5 UNC119 XRCC6 YWHAQ	10 interactors: ANXA1 ANXA7 CDKN1A GSK3B NR1H2 PIN1 RAP1B RCC1 SMN1 TK1
Entrez ID		301	51380
HPRD ID		01060	16763
Ensembl ID		ENSG00000135046	ENSG00000139631
Uniprot IDs		P04083 Q5TZZ9	Q86V02 Q96JQ3 Q9Y600
PDB IDs		1AIN 1BO9 1QLS	2JIS
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Biosynthetic Process Viral Process Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Cellular Protein Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Regulation Of Caveolin-mediated Endocytosis Establishment Of Integrated Proviral Latency Positive Regulation Of Transferase Activity Establishment Of Viral Latency Cellular Macromolecule Catabolic Process Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death DNA Repair Response To Growth Factor Negative Regulation Of Protein Metabolic Process Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Signal Transduction Peptidyl-amino Acid Modification Organ Development Magnesium Ion Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Programmed Cell Death Organelle Organization Catabolic Process Cell Death Death Positive Regulation Of Gene Expression, Epigenetic Regulation Of Transcription, DNA-templated Response To Stimulus Regulation Of Gene Expression Peptidyl-lysine Modification Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Brain Development Reproductive Structure Development Ubiquitin-dependent Protein Catabolic Process Reproductive System Development Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity	Regulation Of Cellular Component Organization Response To Organic Cyclic Compound Response To Organic Substance Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Negative Regulation Of Transport Positive Regulation Of Fatty Acid Biosynthetic Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Ras GTPase Activity Response To Inorganic Substance Response To Steroid Hormone Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Response To Glucocorticoid Regulation Of Cell Cycle Process Cellular Response To Organic Substance Response To Corticosteroid Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Ras GTPase Activity Epithelial Cell Differentiation Response To X-ray Positive Regulation Of Protein Metabolic Process Positive Regulation Of Fatty Acid Metabolic Process Regulation Of Fatty Acid Biosynthetic Process Regulation Of Protein Transport Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Ras Protein Signal Transduction Regulation Of Establishment Of Protein Localization Positive Regulation Of Protein Phosphorylation Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Regulation Of GTPase Activity Regulation Of Protein Localization Positive Regulation Of Cellular Metabolic Process Response To Lipid Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphorylation Response To Metal Ion Cellular Response To Heat Positive Regulation Of Protein Modification Process Tissue Development Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Regulation Of Cell Cycle Response To Hormone Positive Regulation Of High-density Lipoprotein Particle Assembly Neutrophil Clearance Positive Regulation Of Secretion Of Lysosomal Enzymes Positive Regulation Of Pancreatic Juice Secretion
Tagcloud ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	ado birth blotting born cdo deficiency died disruption drinking engineered g2 g3 gpx hplc indicated ko lactoferrin northern offspring physiological prolactin restored southern studying supplementation survived taurine taut verified
Tagcloud (Difference) ?		aldh1a1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1	ado birth blotting born cdo deficiency died disruption drinking engineered g2 g3 gpx hplc indicated ko lactoferrin northern offspring physiological prolactin restored southern studying supplementation survived taurine taut verified
Tagcloud (Intersection) ?