TUBB4B and POT1

Number of citations of the paper that reports this interaction (PMID 21044950)
9

Data Source:
BioGRID (two hybrid)

		TUBB4B	POT1
Gene Name		tubulin, beta 4B class IVb	protection of telomeres 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Microtubule Vesicle Extracellular Vesicular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding MHC Class I Protein Binding Unfolded Protein Binding	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Single-stranded Telomeric DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Movement Of Cell Or Subcellular Component Organelle Organization Natural Killer Cell Mediated Cytotoxicity Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport	Telomere Maintenance Telomere Maintenance Via Telomerase Telomere Capping Telomere Formation Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation	Telomere Maintenance Packaging Of Telomere Ends DNA Damage/Telomere Stress Induced Senescence Chromosome Maintenance Cellular Senescence Meiotic synapsis
Drugs		Albendazole Mebendazole Epothilone D Epothilone B
Diseases
GWAS
Protein-Protein Interactions		13 interactors: ACD CDKN2A DLEU1 DLST ENOX2 POT1 PSME1 SCG2 SOCS6 SOCS7 TERF1 TINF2 TUBG1	166 interactors: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C15orf57 C2orf74 CALD1 CAMK1D CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 RBKS RECQL4 RGS14 RIF1 RPAP1 RPSA RTN4 SARS SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TERF2 TINF2 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIBG WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790
Entrez ID		10383	25913
HPRD ID		04043	07572
Ensembl ID		ENSG00000188229	ENSG00000128513
Uniprot IDs		P68371	A8MTK3 Q5MJ33 Q9NUX5
PDB IDs			1XJV 3KJO 3KJP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Negative Regulation Of Transferase Activity Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Kinase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Positive Regulation Of Telomerase Activity Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Growth Telomere Maintenance Via Telomerase Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Endopeptidase Activity Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Organelle Organization RNA-dependent DNA Replication Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process	Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Regulation Of Cellular Component Organization Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Negative Regulation Of Telomere Maintenance Small Molecule Metabolic Process Cellular Component Assembly Regulation Of Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Cytoskeleton Organization Organic Acid Metabolic Process Response To Stimulus Catabolic Process Regulation Of Binding Cellular Process Carboxylic Acid Metabolic Process Cofactor Metabolic Process Protein Localization To Chromosome Cellular Response To Stimulus Actin Filament Organization Protection From Non-homologous End Joining At Telomere Response To Abiotic Stimulus Carbohydrate Catabolic Process Carbohydrate Biosynthetic Process Protein Localization Telomere Assembly Telomere Capping Positive Regulation Of Organelle Organization Nervous System Development Cellular Protein Localization Response To Stress Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Telomere Maintenance Cellular Metabolic Process Pyruvate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of DNA Replication Response To External Stimulus Actin Cytoskeleton Organization Glycolytic Process Cellular Localization Regulation Of Protein Metabolic Process Gluconeogenesis Sequestering Of Actin Monomers Regulation Of Neuron Projection Development Xenobiotic Metabolic Process Cellular Response To Xenobiotic Stimulus Developmental Process
Tagcloud ?			0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Difference) ?			0mug celltiter chemosensitivity ddp downregulate fluorescein formerly gastroesophageal gc iodide isothiocyanate junction n87 nci oncological oxa oxaliplatin performing pip platinum propodium ptop telomere telomeric tint1 tpp1 trastuzumab trf2 trf2ip
Tagcloud (Intersection) ?