TUBB4B and DLST

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TUBB4B	DLST
Gene Name		tubulin, beta 4B class IVb	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Microtubule Vesicle Extracellular Vesicular Exosome	Nucleus Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex Extracellular Vesicular Exosome
	Molecular Function	Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding MHC Class I Protein Binding Unfolded Protein Binding	Dihydrolipoyllysine-residue Succinyltransferase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Folding Movement Of Cell Or Subcellular Component Organelle Organization Natural Killer Cell Mediated Cytotoxicity Cellular Protein Metabolic Process 'de Novo' Posttranslational Protein Folding Spindle Assembly Protein Polymerization Transmembrane Transport	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process
Pathways		Transport of connexons to the plasma membrane Hedgehog 'off' state Formation of tubulin folding intermediates by CCT/TriC Regulation of PLK1 Activity at G2/M Transition Prefoldin mediated transfer of substrate to CCT/TriC Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding Gap junction trafficking and regulation Recruitment of mitotic centrosome proteins and complexes Orphan transporters Gap junction assembly Gap junction trafficking Factors involved in megakaryocyte development and platelet production Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System Mitotic Prometaphase Organelle biogenesis and maintenance Axon guidance Separation of Sister Chromatids Translocation of GLUT4 to the plasma membrane G2/M Transition L1CAM interactions Mitotic Anaphase Recycling pathway of L1 Recruitment of NuMA to mitotic centrosomes M Phase Intraflagellar transport Post-chaperonin tubulin folding pathway Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Protein folding Kinesins Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Assembly of the primary cilium Anchoring of the basal body to the plasma membrane Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Signaling by Hedgehog Chaperonin-mediated protein folding Centrosome maturation	Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs		Albendazole Mebendazole Epothilone D Epothilone B
Diseases
GWAS			Non-small cell lung cancer ( 23144319)
Protein-Protein Interactions		13 interactors: ACD CDKN2A DLEU1 DLST ENOX2 POT1 PSME1 SCG2 SOCS6 SOCS7 TERF1 TINF2 TUBG1	15 interactors: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1
Entrez ID		10383	1743
HPRD ID		04043	00520
Ensembl ID		ENSG00000188229	ENSG00000119689
Uniprot IDs		P68371	B7Z6J1 P36957
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Negative Regulation Of Transferase Activity Regulation Of Telomerase Activity Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Regulation Of DNA Replication Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomerase Activity Negative Regulation Of Catalytic Activity Telomere Maintenance Regulation Of Chromosome Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protein Kinase Activity Protein Localization To Chromosome, Telomeric Region Telomere Capping Regulation Of Catalytic Activity Negative Regulation Of Kinase Activity Positive Regulation Of Telomerase Activity Chromosome Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Growth Telomere Maintenance Via Telomerase Positive Regulation Of Proteolysis Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Metabolic Process Negative Regulation Of Phosphorylation Positive Regulation Of Organelle Organization Positive Regulation Of Endopeptidase Activity Positive Regulation Of DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Positive Regulation Of Peptidase Activity Regulation Of Organelle Organization RNA-dependent DNA Replication Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Cell Cycle Positive Regulation Of Cellular Metabolic Process
Tagcloud ?			acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis
Tagcloud (Difference) ?			acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis
Tagcloud (Intersection) ?