TUBB4B and SOCS7

Number of citations of the paper that reports this interaction (PubMedID 12052866)
44

Data Source:
HPRD (in vivo)

		TUBB4B	SOCS7
Description		tubulin beta 4B class IVb	suppressor of cytokine signaling 7
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Microtubule Axonemal Microtubule Cilium Microtubule Cytoskeleton Motile Cilium Azurophil Granule Lumen Sperm Flagellum Cell Projection Intercellular Bridge Extracellular Exosome Mitotic Spindle Extracellular Vesicle	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Cul5-RING Ubiquitin Ligase Complex
	Molecular Function	Nucleotide Binding Double-stranded RNA Binding GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding MHC Class I Protein Binding Metal Ion Binding Unfolded Protein Binding	Protein Binding SH3 Domain Binding Signaling Adaptor Activity Phosphorylation-dependent Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Flagellated Sperm Motility Natural Killer Cell Mediated Cytotoxicity	Insulin Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Layer Formation In Cerebral Cortex Intracellular Signal Transduction Reelin-mediated Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Neuron Migration
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Anchoring of the basal body to the plasma membrane Cargo trafficking to the periciliary membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins PKR-mediated signaling
Drugs		Albendazole Mebendazole Epothilone D Patupilone Oxibendazole CYT997 Phenethyl Isothiocyanate
Diseases
GWAS			Ovarian cancer ( 23535730)
Interacting Genes		23 interacting genes: ACD CDKN2A CEBPA DAPK1 DLEU1 DLST ENOX2 LINC01554 NEAT1 NEDD8 OGT POT1 PSME1 PTEN RSPH1 SCG2 SOCS6 SOCS7 SUMO2 TERF1 TINF2 TUBG1 WEE2-AS1	25 interacting genes: CYSRT1 DAB1 EGFR EXOSC8 GAS2L2 GRB2 HSPB8 IRS2 IRS4 LENG8 MDFI MISP NCK1 NSMF OSTF1 PIK3R1 PIK3R2 PLCG1 SH3RF1 SORBS2 SORBS3 TNS2 TUBA1A TUBB4B YES1
Entrez ID		10383	30837
HPRD ID		04043	12299
Ensembl ID		ENSG00000188229	ENSG00000274211
Uniprot IDs		P68371	A0A5F9YLF9 O14512
PDB IDs		7UN1 7UNG 8J07 8SH7
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Assembly Negative Regulation Of Telomere Maintenance Via Telomerase Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Proteolysis Positive Regulation Of Telomere Maintenance Telomere Maintenance Via Telomerase Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Telomere Organization Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Negative Regulation Of DNA Metabolic Process Negative Regulation Of Cell Size Telomeric D-loop Disassembly G-rich Strand Telomeric DNA Binding Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region Chromosome, Telomeric Region Chromosome Organization Organelle Organization Protein Tag Activity Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Nuclear Body Organization DNA Biosynthetic Process SUMO Transferase Activity Nucleus Negative Regulation Of Metabolic Process Meiotic Spindle Organization Regulation Of Chromosome Organization Protein Modification Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cellular Component Organization	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Motility Insulin Receptor Signaling Pathway Neurotrophin TRKA Receptor Binding Cell Migration Enzyme-linked Receptor Protein Signaling Pathway Protein Phosphatase Binding Phosphotyrosine Residue Binding Focal Adhesion Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Phosphatidylinositol 3-kinase Binding Cytoskeletal Anchor Activity Insulin Receptor Binding Cell Surface Receptor Signaling Pathway Cytoplasm Structural Constituent Of Cytoskeleton Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Supramolecular Fiber Organization Intracellular Signaling Cassette Natural Killer Cell Mediated Cytotoxicity Regulation Of MAPK Cascade 1-phosphatidylinositol-3-kinase Regulator Activity Natural Killer Cell Mediated Immunity Regulation Of Actin Filament Organization Phosphatidylinositol 3-kinase Activator Activity Regulation Of Protein Localization To Cell Periphery Phosphatidylinositol 3-kinase Complex, Class IA Phosphatidylinositol 3-kinase Regulatory Subunit Binding Regulation Of Cytoskeleton Organization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Organization Insulin Receptor Substrate Binding Leukocyte Mediated Cytotoxicity Regulation Of D-glucose Transmembrane Transport ERBB Signaling Pathway Regulation Of Actin Filament-based Process Signal Transduction Signaling Adaptor Activity Anchoring Junction Actin Filament Intracellular Glucose Homeostasis Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Stress Fiber Assembly Regulation Of Cell Communication Regulation Of Signaling Cytoskeleton Organization Cellular Response To Insulin Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cell Motility
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