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TUBB4B and CDKN2A
Number of citations of the paper that reports this interaction (PMID
17955473
)
10
Data Source:
BioGRID
(pull down)
TUBB4B
CDKN2A
Gene Name
tubulin, beta 4B class IVb
cyclin-dependent kinase inhibitor 2A
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytosol
Cytoskeleton
Microtubule
Vesicle
Extracellular Vesicular Exosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Nuclear Body
Senescence-associated Heterochromatin Focus
Protein Complex
Molecular Function
Double-stranded RNA Binding
GTPase Activity
Structural Constituent Of Cytoskeleton
GTP Binding
MHC Class I Protein Binding
Unfolded Protein Binding
P53 Binding
DNA Binding
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Poly(A) RNA Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Inhibitor Activity
MDM2/MDM4 Family Protein Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Protein Folding
Movement Of Cell Or Subcellular Component
Organelle Organization
Natural Killer Cell Mediated Cytotoxicity
Cellular Protein Metabolic Process
'de Novo' Posttranslational Protein Folding
Spindle Assembly
Protein Polymerization
Transmembrane Transport
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Negative Regulation Of Cell-matrix Adhesion
Transcription, DNA-templated
RRNA Processing
Negative Regulation Of Protein Kinase Activity
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Cycle Arrest
Ras Protein Signal Transduction
Negative Regulation Of Cell Proliferation
Apoptotic Mitochondrial Changes
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Cell Growth
Negative Regulation Of B Cell Proliferation
Regulation Of Protein Stability
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Protein Sumoylation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Senescence-associated Heterochromatin Focus Assembly
Negative Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Regulation Of Protein Export From Nucleus
Somatic Stem Cell Division
Protein Stabilization
Negative Regulation Of Ubiquitin-protein Transferase Activity
Protein K63-linked Ubiquitination
Positive Regulation Of Cell Cycle Arrest
Cellular Senescence
Replicative Senescence
Regulation Of Apoptotic DNA Fragmentation
Positive Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Cellular Senescence
Pathways
Transport of connexons to the plasma membrane
Hedgehog 'off' state
Formation of tubulin folding intermediates by CCT/TriC
Regulation of PLK1 Activity at G2/M Transition
Prefoldin mediated transfer of substrate to CCT/TriC
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding
Gap junction trafficking and regulation
Recruitment of mitotic centrosome proteins and complexes
Orphan transporters
Gap junction assembly
Gap junction trafficking
Factors involved in megakaryocyte development and platelet production
Resolution of Sister Chromatid Cohesion
Mitotic G2-G2/M phases
Mitotic Metaphase and Anaphase
Adaptive Immune System
Mitotic Prometaphase
Organelle biogenesis and maintenance
Axon guidance
Separation of Sister Chromatids
Translocation of GLUT4 to the plasma membrane
G2/M Transition
L1CAM interactions
Mitotic Anaphase
Recycling pathway of L1
Recruitment of NuMA to mitotic centrosomes
M Phase
Intraflagellar transport
Post-chaperonin tubulin folding pathway
Loss of Nlp from mitotic centrosomes
MHC class II antigen presentation
Protein folding
Kinesins
Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane
Assembly of the primary cilium
Anchoring of the basal body to the plasma membrane
Cell Cycle, Mitotic
Loss of proteins required for interphase microtubule organization from the centrosome
Signaling by Hedgehog
Chaperonin-mediated protein folding
Centrosome maturation
Cyclin D associated events in G1
Oxidative Stress Induced Senescence
G1 Phase
Cellular Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Mitotic G1-G1/S phases
Cell Cycle, Mitotic
Oxidative Stress Induced Senescence
Cellular Senescence
Oncogene Induced Senescence
Drugs
Albendazole
Mebendazole
Epothilone D
Epothilone B
Diseases
GWAS
Abdominal aortic aneurysm (
20622881
)
Breast cancer (
23535729
20453838
)
Coronary artery calcification (
23561647
)
Coronary heart disease (
21626137
21971053
17554300
21378990
)
Endometriosis (
23104006
)
Glioma (
21531791
19578367
)
Intracranial aneurysm (
18997786
20364137
)
Melanoma (
21983787
19578364
)
Myocardial infarction (
17478679
)
Myocardial infarction (early onset) (
19198609
)
Platelet counts (
22139419
)
Type 2 diabetes (
21573907
18372903
20581827
19401414
17463246
17463248
17463249
23209189
)
Protein-Protein Interactions
13 interactors:
ACD
CDKN2A
DLEU1
DLST
ENOX2
POT1
PSME1
SCG2
SOCS6
SOCS7
TERF1
TINF2
TUBG1
94 interactors:
ACLY
ACTB
ACTG1
ACTN4
AHNAK
ANKRD12
ARFIP2
BCL2L1
BECN1
CARF
CCDC183
CCND1
CCND2
CCNG1
CDC45
CDC5L
CDC6
CDC7
CDK4
CDK6
CDKN2AIP
CDKN2C
CRELD2
CTBP2
DEAF1
E2F1
E4F1
EEF2
EGR1
EPHA3
FN1
GAPDH
GGA1
GGA3
GMNN
GSPT1
HIF1A
HIST3H2BB
HNRNPA2B1
HNRNPC
HNRNPU
HSP90AA1
HSP90AB1
HSPA4
HSPA8
HUWE1
KAT5
MAPK10
MAPK8
MCM10
MCM2
MCM5
MCM6
MDM2
MMRN1
MTR
MYC
MYL12A
NCL
NMI
ORC4
PCNA
PDCD6
PEX19
PLEKHA8
PPP1R9B
PRKCA
PSMC3
RIN2
RPS7
RUVBL2
SERTAD1
SIVA1
SLC4A1
SMARCA4
SNRPA
SNRPB
TBRG1
TDRD7
TP63
TPI1
TRIP12
TUBA1A
TUBA1C
TUBB
TUBB4B
UBE2A
UBE4B
USP26
WRN
YY1
ZFP91
ZNF227
ZNF410
Entrez ID
10383
1029
HPRD ID
04043
02542
Ensembl ID
ENSG00000188229
ENSG00000147889
Uniprot IDs
P68371
G3XAG3
K7PML8
P42771
Q8N726
PDB IDs
1A5E
1BI7
1DC2
2A5E
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Negative Regulation Of DNA Replication
Negative Regulation Of Transferase Activity
Regulation Of Telomerase Activity
Regulation Of Telomere Maintenance
Telomere Assembly
Negative Regulation Of DNA Metabolic Process
Regulation Of DNA Replication
Regulation Of DNA Biosynthetic Process
Negative Regulation Of Telomerase Activity
Negative Regulation Of Catalytic Activity
Telomere Maintenance
Regulation Of Chromosome Organization
Negative Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Protein Metabolic Process
Negative Regulation Of Chromosome Organization
Negative Regulation Of DNA Biosynthetic Process
Telomere Maintenance Via Telomere Lengthening
Negative Regulation Of Protein Kinase Activity
Protein Localization To Chromosome, Telomeric Region
Telomere Capping
Regulation Of Catalytic Activity
Negative Regulation Of Kinase Activity
Positive Regulation Of Telomerase Activity
Chromosome Organization
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Growth
Telomere Maintenance Via Telomerase
Positive Regulation Of Proteolysis
Regulation Of Proteolysis
Positive Regulation Of Telomere Maintenance
Negative Regulation Of Protein Phosphorylation
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Phosphorylation
Positive Regulation Of Organelle Organization
Positive Regulation Of Endopeptidase Activity
Positive Regulation Of DNA Biosynthetic Process
Positive Regulation Of DNA Metabolic Process
Positive Regulation Of Peptidase Activity
Regulation Of Organelle Organization
RNA-dependent DNA Replication
Negative Regulation Of JAK-STAT Cascade
Negative Regulation Of Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Cell Cycle Process
Mitotic Cell Cycle
Mitotic Cell Cycle Process
Cell Cycle
G1/S Transition Of Mitotic Cell Cycle
Response To Stress
Cellular Response To Stress
Regulation Of Metabolic Process
Regulation Of Cell Cycle
Response To Abiotic Stimulus
Cellular Response To DNA Damage Stimulus
Response To Radiation
Negative Regulation Of Cell Cycle
Response To Light Stimulus
Regulation Of Mitotic Cell Cycle
Cell Division
Cellular Nitrogen Compound Metabolic Process
Response To UV
Positive Regulation Of Metabolic Process
Nucleobase-containing Compound Metabolic Process
Organelle Organization
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
DNA Replication
DNA Replication Initiation
Nitrogen Compound Metabolic Process
Chromosome Organization
Cellular Metabolic Process
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Cellular Metabolic Process
DNA Metabolic Process
Positive Regulation Of Cell Cycle Phase Transition
Cellular Response To Radiation
Regulation Of Protein Metabolic Process
DNA-dependent DNA Replication
Regulation Of Mitotic Cell Cycle Phase Transition
Cell Cycle Checkpoint
Regulation Of Cell Proliferation
Cellular Macromolecule Biosynthetic Process
Regulation Of Cell Cycle Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Regulation Of Cell Cycle G1/S Phase Transition
Macromolecule Biosynthetic Process
Positive Regulation Of Mitotic Cell Cycle Phase Transition
Cellular Response To Stimulus
DNA Strand Elongation Involved In DNA Replication
DNA Strand Elongation
Tagcloud
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Difference)
?
a134c
abp
allelic
ankyrin
balb
cdk6
cdnas
chr
congenic
d2
dba
g232a
ifna
inbred
inefficient
ink4c
le
multigenic
mus
p15
p16
p18
pctr1
plasmacytoma
pristane
spretus
typed
Tagcloud (Intersection)
?