SF3B4 and ITSN1

Number of citations of the paper that reports this interaction (PMID 18654987)
7

Data Source:
BioGRID (two hybrid)

		SF3B4	ITSN1
Gene Name		splicing factor 3b, subunit 4, 49kDa	intersectin 1 (SH3 domain protein)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex	Cytosol Plasma Membrane Coated Pit Lamellipodium Cell Junction Endocytic Vesicle Neuron Projection Synapse
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding	Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Calcium Ion Binding Protein Binding Kinase Activator Activity Protein Complex Scaffold Proline-rich Region Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Positive Regulation Of MRNA Splicing, Via Spliceosome	Small GTPase Mediated Signal Transduction Axon Guidance Positive Regulation Of Rho GTPase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway	Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Height ( 20881960 18391951)
Protein-Protein Interactions		42 interactors: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 NCK2 NUB1 PPP1R16B PRPF40A RBM39 RBM4 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 UBASH3A UBC WBP4 WDR77 ZCCHC10	82 interactors: AGFG1 AGFG2 AP2B1 ARF6 ARFIP2 ARHGAP31 ASAP2 CCNO CDC42 CEP85L CLIP2 CLTC CSNK2B CYTH1 DAB2 DES DISC1 DLGAP1 DNM1 DNM2 EEF1A1 EPHB2 EPN2 EPS15 EPS15L1 FCHSD2 FNBP1 FNBP4 GAREML GCC1 GOLGA5 HIP1 HRAS ITSN2 KHDRBS1 KIF16B KIF5A LMO4 MAPK6 MAPK8IP2 MRPL20 MTUS2 PACSIN3 PDCD6IP PFDN5 PICALM PIK3AP1 PIK3C2B PIK3R1 PLK1 PPFIA2 PPL PREX1 RAB11FIP2 RAB5A RABEP1 RAI14 RNF40 RPS6KA5 SCAMP1 SCOC SF3B4 SH3GL2 SMARCC2 SNAP23 SNAP25 SNX5 SOS1 SPDL1 SPRY2 STON2 SYNJ1 SYNJ2 TK1 TRIM8 TSG101 UBE2K UNC119 WASL WBP11 ZAK ZFPM2
Entrez ID		10262	6453
HPRD ID		12028	03898
Ensembl ID		ENSG00000143368	ENSG00000205726
Uniprot IDs		B3KUJ0 Q15427	A7XZY7 F8W7U0 Q15811 Q6PD56
PDB IDs		1X5T 1X5U	1KI1 2KGR 2KHN 3FIA 3QBV 4IIM
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Cellular Response To Growth Factor Stimulus Regulation Of ERBB Signaling Pathway Response To Growth Factor Negative Regulation Of Protein Metabolic Process Immune System Process Response To External Stimulus Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Signal Transduction Regulation Of Cellular Process Stress-activated MAPK Cascade Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process	Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Endocytosis Vesicle Organization Cellular Localization Establishment Of Localization In Cell Regulation Of Vesicle-mediated Transport Signaling Synaptic Transmission Regulation Of Cellular Component Organization Establishment Of Organelle Localization Cell Communication Regulation Of Signaling Organelle Organization Protein Localization Cell Differentiation Synaptic Vesicle Transport Cell-cell Signaling Membrane Budding Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Localization Regulation Of ERBB Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Post-Golgi Vesicle-mediated Transport Establishment Of Vesicle Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Vesicle Localization Transport Cell Morphogenesis Involved In Neuron Differentiation Axon Guidance Generation Of Neurons Cell Morphogenesis Involved In Differentiation Membrane Organization Cell Projection Morphogenesis Cell Part Morphogenesis Establishment Of Protein Localization Cell Projection Organization Synaptic Vesicle Recycling Axonogenesis Cellular Protein Complex Assembly Neurogenesis Regulation Of Catalytic Activity Regulation Of Signal Transduction Intracellular Transport Cell Morphogenesis
Tagcloud ?			cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Difference) ?			cbr1 david degs downloaded dyrk1a egr1 encyclopedia geo gse hmgn1 hypergeometric interrogate kegg kyoto macromolecular multiarray mycmax mzf1 nfe2 nfy olf1 ominibus pax5 rma rp58 son srebp1 tmem50b ttc3
Tagcloud (Intersection) ?