SF3B4 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		SF3B4	BAG4
Description		splicing factor 3b subunit 4	BAG cochaperone 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U2 SnRNP U12-type Spliceosomal Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Splicing Factor Binding	Adenyl-nucleotide Exchange Factor Activity RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Protein Stabilization Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Negative Regulation Of MRNA Modification Ruffle Assembly Negative Regulation Of Protein Targeting To Mitochondrion
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth length ( 25281659) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 18391951 20881960 31562340) Infant length ( 25281659) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		115 interacting genes: APBB1 BAG3 BAG4 BAIAP2 BMPR1A CD2BP2 CHERP CPSF7 CTTN CWF19L2 DDX17 DDX42 DMRTB1 EEF1A1 EFTUD2 EWSR1 FARSB FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 KHDRBS2 MAPK9 METTL17 MIR1-1 MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR141 MIR145 MIR155 MIR15B MIR16-1 MIR16-2 MIR17 MIR18B MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR20B MIR21 MIR221 MIR222 MIR25 MIR29A MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-3 MIR9-1 MIR92A1 MIR92A2 MIR93 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7G MIRLET7I NCK2 NUB1 OGT PPP1R16B PRPF6 QARS1 RAMAC RBFOX2 RBM10 RBM39 RBM4 RPP25 SEC24D SF1 SF3B2 SFPQ SRSF6 SS18L1 SUMO4 TCAF1 TCERG1 TFG TLE5 TRAF4 UBASH3A WBP4 WDR4 WDR77 WHR1 ZCCHC10 ZNF3 ZNF48	141 interacting genes: ABI2 ACOT7 ADAMTSL4 ALG13 ANKHD1 APOBEC1 ARID5A ATAD2 ATOSB ATP23 BAP1 BCAS3 BCL2 BCL6B BEX1 BLZF1 BMS1 C3orf38 CASP2 CASZ1 CBFA2T2 CCL5 CEP55 CIMAP1C CPSF7 DDIT4L DIRAS3 DMRTB1 DZIP3 EFEMP1 EIF4ENIF1 EPSTI1 ERRFI1 FAM222B FARS2 FTH1 FYN GLCE GPANK1 GPS2 GRAP2 GRIP1 HOXA1 HSPA1A HSPA1B HSPA1L HSPA2 HSPA6 HSPA8 IL13RA2 IL24 IST1 ITIH5 KCTD6 KCTD7 KIF5B KLK5 KLK7 KLK9 KRT31 KRTAP13-1 KRTAP13-4 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP6-3 LASP1 LRATD2 LYPD3 MAGED1 MEI4 MRC2 MTA3 MYOZ1 MYOZ3 MYPOP NAT2 ODF1 P4HA3 PDCD6 PDLIM2 PEF1 PGRMC2 PHF19 PKP2 PLAC8 PPIL6 PRDM14 PRPF6 PRRC2B PSMB5 PYCR3 QKI RAMAC RASL10B RBFOX2 RBM22 RBM42 RBM7 RBPMS RHOBTB2 RNF20 RPL22 RUNX1 SAMD4A SAXO1 SAXO4 SCGB3A1 SF1 SF3B4 SH3RF2 SIAH1 SNRPA SNRPB SNRPC SNRPN SNW1 SS18L1 SUOX TBC1D3B TBC1D3G TBC1D7 TCL1B TEKT5 TFAP2D TFIP11 THRSP TINAGL1 TLE5 TNFRSF1A TNFRSF25 TRAPPC6A TSG101 UNKL USP22 VIM VPS37C ZBTB45 ZBTB5 ZIM2
Entrez ID		10262	9530
HPRD ID		12028	04861
Ensembl ID		ENSG00000143368	ENSG00000156735
Uniprot IDs		B3KUJ0 Q15427	O95429
PDB IDs		1X5T 5GVQ 5Z56 5Z57 5Z58 6AH0 6AHD 6QX9 6Y53 6Y5Q 7ABG 7ABH 7ABI 7DVQ 7EVO 7ONB 7QTT 7VPX 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y7E	1M62 1M7K
Enriched GO Terms of Interacting Partners?		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity RISC Complex Regulatory NcRNA-mediated Gene Silencing Post-transcriptional Regulation Of Gene Expression MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Translation Negative Regulation Of Metabolic Process Extracellular Vesicle MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Translation Regulation Of MRNA Metabolic Process MRNA Destabilization RNA Destabilization Negative Regulation Of Cell Migration Negative Regulation Of Cell Motility Negative Regulation Of Angiogenesis Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vasculature Development Negative Regulation Of Locomotion Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of RNA Stability Regulation Of MRNA Stability Negative Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cytokine Production Negative Regulation Of Protein Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of Multicellular Organismal Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Sprouting Angiogenesis MRNA Processing Negative Regulation Of Signal Transduction Regulation Of Cell Migration Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility	MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Spliceosomal Complex Protein Refolding MRNA Metabolic Process MRNA Processing ATP-dependent Protein Folding Chaperone Intermediate Filament RNA Binding RNA Splicing Protein Binding Hair Cycle C3HC4-type RING Finger Domain Binding Transcription Corepressor Activity ATP-dependent Protein Disaggregase Activity Protein Folding Chaperone Cellular Heat Acclimation Nucleus Heat Shock Protein Binding U1 SnRNP U4/U6 X U5 Tri-snRNP Complex Regulation Of RNA Splicing RNA Processing RNA Metabolic Process Negative Regulation Of Protein Ubiquitination Regulation Of Protein Ubiquitination Catalytic Step 2 Spliceosome Regulation Of MRNA Metabolic Process Identical Protein Binding Negative Regulation Of Post-translational Protein Modification Negative Regulation Of Inclusion Body Assembly Keratin Filament Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Post-translational Protein Modification SnRNP Binding Negative Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding MRNA Binding Response To Temperature Stimulus Nucleic Acid Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome U2-type Prespliceosome Unfolded Protein Binding Positive Regulation Of Antibacterial Peptide Production Epidermal Lamellar Body Macromolecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Calcium-dependent Protein Binding Blood Microparticle
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