SF3B4 and FRK

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SF3B4	FRK
Gene Name		splicing factor 3b, subunit 4, 49kDa	fyn-related Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex	Intracellular Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Nucleotide Binding Protein Binding Poly(A) RNA Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Gene Expression Positive Regulation Of MRNA Splicing, Via Spliceosome	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Migration Actin Cytoskeleton Organization Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Height ( 20881960 18391951)	Age-related macular degeneration ( 21665990) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Urate levels ( 23263486)
Protein-Protein Interactions		42 interactors: APBB1 BAG3 BAIAP2 BMPR1A CHERP CWF19L2 DDX17 DDX42 EFTUD2 EWSR1 FKBP1A FRK GRB2 HNRNPD HNRNPF HNRNPH1 HNRNPUL1 HSPB7 ILF3 ITSN1 MAPK9 METTL17 NCK2 NUB1 PPP1R16B PRPF40A RBM39 RBM4 SEC24D SF1 SF3B2 SRSF6 SS18L1 STK19 SUMO4 TCAF1 TCERG1 UBASH3A UBC WBP4 WDR77 ZCCHC10	4 interactors: BNIP2 KHDRBS1 RB1 SF3B4
Entrez ID		10262	2444
HPRD ID		12028	05954
Ensembl ID		ENSG00000143368
Uniprot IDs		B3KUJ0 Q15427	P42685
PDB IDs		1X5T 1X5U
Enriched GO Terms of Interacting Partners?		RNA Processing RNA Splicing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of RNA Splicing Regulation Of RNA Metabolic Process Regulation Of Gene Expression Circadian Regulation Of Translation Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated RNA Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Development Cellular Response To Growth Factor Stimulus Regulation Of ERBB Signaling Pathway Response To Growth Factor Negative Regulation Of Protein Metabolic Process Immune System Process Response To External Stimulus Regulation Of Circadian Rhythm Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Signal Transduction Regulation Of Cellular Process Stress-activated MAPK Cascade Fc Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process	Positive Regulation Of Cellular Metabolic Process Cell Cycle Arrest Positive Regulation Of RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Positive Regulation Of Metabolic Process Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Striated Muscle Cell Differentiation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore MRNA Processing Positive Regulation Of Macrophage Differentiation Microtubule Cytoskeleton Organization Regulation Of RNA Export From Nucleus Negative Regulation Of Cell Cycle Positive Regulation Of Translational Initiation Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Positive Regulation Of Chromosome Segregation Muscle Structure Development Regulation Of Sister Chromatid Cohesion MRNA Metabolic Process Hepatocyte Apoptotic Process RNA Processing Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA Splicing, Via Spliceosome Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Protein Localization To Chromosome Neuron Maturation Sister Chromatid Cohesion Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Mitotic Cell Cycle Positive Regulation Of RNA Splicing Regulation Of Signal Transduction Microtubule-based Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Establishment Of Chromosome Localization
Tagcloud ?			accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma sirna src suppressing suppressive
Tagcloud (Difference) ?			accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma sirna src suppressing suppressive
Tagcloud (Intersection) ?