ABI1 and EPS8

Number of citations of the paper that reports this interaction (PMID 10499589)
82

Data Source:
HPRD (in vitro, in vivo)

		ABI1	EPS8
Gene Name		abl-interactor 1	epidermal growth factor receptor pathway substrate 8
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Cell Junction Filopodium Growth Cone SCAR Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Tyrosine Kinase Activator Activity Protein Complex Binding	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding
	Biological Process	Somitogenesis Movement Of Cell Or Subcellular Component Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS			Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		27 interactors: ABL1 APBB1 CACNA1A CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2	54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3
Entrez ID		10006	2059
HPRD ID		04336	02563
Ensembl ID		ENSG00000136754	ENSG00000151491
Uniprot IDs		B6VEX3 B6VEX4 B6VEX5 Q8IZP0	B4DX66 B4E3T6 Q12929
PDB IDs			2E8M
Enriched GO Terms of Interacting Partners?		Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Differentiation Neuron Development Locomotion Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Axonogenesis Neuron Differentiation Regulation Of Actin Filament-based Process Axon Development Actin Cytoskeleton Organization Chemotaxis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoskeleton Organization Cell Development Actin Filament Organization Generation Of Neurons Neurogenesis Anatomical Structure Morphogenesis Nervous System Development Regulation Of Actin Filament Length Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Immune Response-regulating Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization System Development Rac Protein Signal Transduction Cell Differentiation Fc Receptor Signaling Pathway Multicellular Organismal Development Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Actin Polymerization Or Depolymerization Anatomical Structure Development	Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor
Tagcloud ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wounding	adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly
Tagcloud (Intersection) ?		wound