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ABI1 and HSPA8
Number of citations of the paper that reports this interaction (PubMedID
31980649
)
68
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
ABI1
HSPA8
Description
abl interactor 1
heat shock protein family A (Hsp70) member 8
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
Cytoskeleton
Postsynaptic Density
Lamellipodium
Filopodium
Growth Cone
SCAR Complex
Cell Leading Edge
Filopodium Tip
Cell Projection
Neuron Projection
Synapse
Extracellular Exosome
Actin-based Cell Projection
Prp19 Complex
Extracellular Region
Extracellular Space
Nucleus
Nucleoplasm
Spliceosomal Complex
Nucleolus
Cytoplasm
Lysosome
Lysosomal Membrane
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Secretory Granule Lumen
Melanosome
Lysosomal Lumen
Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane
Extracellular Exosome
Blood Microparticle
Lumenal Side Of Lysosomal Membrane
Protein Folding Chaperone Complex
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
Protein Binding
Cytoskeletal Protein Binding
SH3 Domain Binding
Protein Tyrosine Kinase Activator Activity
Signaling Adaptor Activity
Cadherin Binding
Nucleotide Binding
G Protein-coupled Receptor Binding
RNA Binding
Protein Binding
ATP Binding
Hydrolase Activity
ATP Hydrolysis Activity
Enzyme Binding
MHC Class II Protein Complex Binding
Protein-macromolecule Adaptor Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Cadherin Binding
Receptor Ligand Activity
Unfolded Protein Binding
Protein-folding Chaperone Binding
C3HC4-type RING Finger Domain Binding
ATP-dependent Protein Disaggregase Activity
ATP-dependent Protein Folding Chaperone
Biological Process
Somitogenesis
Neuron Migration
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Actin Polymerization Or Depolymerization
Negative Regulation Of Cell Population Proliferation
Megakaryocyte Development
Dendrite Morphogenesis
Cell Projection Morphogenesis
Positive Regulation Of Protein Tyrosine Kinase Activity
Lamellipodium Morphogenesis
MRNA Splicing, Via Spliceosome
MRNA Processing
Protein Folding
Autophagy
Response To Unfolded Protein
Signal Transduction
RNA Splicing
Cellular Response To Starvation
Negative Regulation Of Signal Transduction
Protein Catabolic Process
Positive Regulation Of Cell Migration
Regulation Of Protein Stability
Cellular Response To Stress
Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Protein Refolding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of DNA-templated Transcription
ATP Metabolic Process
Negative Regulation Of Cellular Component Organization
Membrane Organization
Regulation Of Protein Complex Stability
Chaperone-mediated Autophagy
Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy
Cellular Response To Steroid Hormone Stimulus
Clathrin Coat Disassembly
Negative Regulation Of NLRP3 Inflammasome Complex Assembly
Regulation Of Supramolecular Fiber Organization
Negative Regulation Of Supramolecular Fiber Organization
Regulation Of Protein Import
Chaperone-mediated Autophagy Translocation Complex Disassembly
Pathways
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RAC1 GTPase cycle
RAC2 GTPase cycle
RAC3 GTPase cycle
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
Attenuation phase
HSF1-dependent transactivation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
CHL1 interactions
AUF1 (hnRNP D0) binds and destabilizes mRNA
Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
mRNA Splicing - Major Pathway
Clathrin-mediated endocytosis
Protein methylation
GABA synthesis, release, reuptake and degradation
Lipophagy
Chaperone Mediated Autophagy
Late endosomal microautophagy
Respiratory syncytial virus genome transcription
PKR-mediated signaling
Drugs
Dasatinib
(2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
Copper
Artenimol
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular hemoglobin concentration (
29403010
32888494
)
Postoperative acute renal failure after cardiac surgery (
30678657
)
Red cell distribution width (
32888494
)
Serum metabolite levels (
33031748
)
Interacting Genes
67 interacting genes:
ABL1
AKT1
APBB1
C22orf15
CACNA1A
CCDC57
CCHCR1
CYFIP2
DST
DTNB
EIF3H
ENAH
ENKD1
EPS8
EPS8L1
EVL
FAM124B
FBXL19
FHL2
FXR1
GAS7
HHEX
HNRNPK
HOMER1
HOMER3
HSPA8
KIAA0408
KIAA1217
KTN1
LMO1
MAB21L2
MINK1
MRFAP1
MRFAP1L1
NCK1
NCK2
NCKAP1
NEB
NFASC
NIN
OGT
PAK2
PCM1
PRKAA2
PRPF40A
RBM15
RCOR3
SHANK3
SMARCD1
SORBS1
SORBS2
SOS1
SOS2
SPTA1
SPTAN1
SRP68
SRRM1
SYNE2
TCERG1
TLN1
TRIP10
TSC1
TTC23
VARS2
VASP
WASF1
WASF2
92 interacting genes:
ABI1
AIPL1
ALDOB
APOB
ATM
BAG1
BAG2
BAG3
BAG4
BAG6
BRCA1
CCT3
CD40
CDKN2A
CITED1
CLTA
COL7A1
CXCR4
CYCS
DNAJA1
DNAJA3
DPP3
DYNLL1
EGFR
ERBB3
ERH
ESR1
FANCC
FBP1
FNDC3B
FOXP1
GAK
GCH1
GOT2
H3C1
HDAC10
HDAC3
HGS
HLTF
HSF1
HSP90AA1
HSPA1A
HSPBP1
HSPH1
HTN3
HTT
IL32
JAK2
JUN
LALBA
LINC01554
MAPK8
MAPT
NEDD8
NMI
NOA1
PHC1
PPID
PTEN
PTPRF
RAF1
RB1
REL
RGS2
RNF26
SAYSD1
SIRPA
SNCA
SP1
SRRT
ST13
STAT1
STIP1
STMN1
STUB1
SUMO2
SUMO4
TADA3
TCERG1
TGM2
TM4SF1
TNFRSF1A
TRIM38
TSSK6
TTC1
UBC
UCHL1
USP40
VHL
WEE2-AS1
YWHAG
YWHAQ
Entrez ID
10006
3312
HPRD ID
04336
07205
Ensembl ID
ENSG00000136754
ENSG00000109971
Uniprot IDs
A0A0A0MRT6
B6VEX3
B6VEX4
B6VEX5
Q8IZP0
P11142
Q53HF2
V9HW22
PDB IDs
7LXE
3AGY
3AGZ
3ESK
3FZF
3FZH
3FZK
3FZL
3FZM
3LDQ
3M3Z
4H5N
4H5R
4H5T
4H5V
4H5W
4HWI
4KBQ
5AQF
5AQG
5AQH
5AQI
5AQJ
5AQK
5AQL
5AQM
5AQN
5AQO
5AQP
5AQQ
5AQR
5AQS
5AQT
5AQU
5AQV
6B1I
6B1M
6B1N
6ZYJ
Enriched GO Terms of Interacting Partners
?
Regulation Of Actin Filament Organization
Regulation Of Actin Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Regulation Of Actin Filament-based Process
Focal Adhesion
Regulation Of Cytoskeleton Organization
Actin Binding
Cell Projection
Regulation Of Actin Filament Length
Regulation Of Cellular Component Size
Cell Projection Organization
Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Lamellipodium
Postsynaptic Density
Regulation Of Actin Polymerization Or Depolymerization
Actin Filament Organization
Actin Filament-based Process
Actin Cytoskeleton Organization
Regulation Of Organelle Organization
Cytoplasm
Supramolecular Fiber Organization
SCAR Complex
Protein Binding
Regulation Of Protein-containing Complex Assembly
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Translational Initiation
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cellular Component Organization
Postsynapse
Regulation Of Cell Projection Organization
Positive Regulation Of Supramolecular Fiber Organization
Cadherin Binding
Synapse
Positive Regulation Of Cytoskeleton Organization
Lamellipodium Organization
Positive Regulation Of Actin Filament Polymerization
Organelle Organization
Cytoskeleton
Cytosol
Rac Protein Signal Transduction
Negative Regulation Of Supramolecular Fiber Organization
Actin Polymerization Or Depolymerization
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Anchoring Junction
Positive Regulation Of Cellular Component Biogenesis
SH3 Domain Binding
Positive Regulation Of Cellular Component Organization
Cell Cortex
Profilin Binding
Ubiquitin Protein Ligase Binding
Regulation Of Protein Stability
Regulation Of Apoptotic Process
Regulation Of Programmed Cell Death
Protein Folding
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Protein Stabilization
Negative Regulation Of Apoptotic Process
Enzyme Binding
Response To Stress
Negative Regulation Of Programmed Cell Death
Cytosol
Apoptotic Process
Programmed Cell Death
Positive Regulation Of Macromolecule Metabolic Process
Cell Death
Positive Regulation Of Programmed Cell Death
Adenyl-nucleotide Exchange Factor Activity
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Intracellular Signal Transduction
Regulation Of Primary Metabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Metabolic Process
Regulation Of Signal Transduction
Negative Regulation Of Signal Transduction
Regulation Of Protein Modification Process
Heat Shock Protein Binding
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Multicellular Organismal Process
Hsp70 Protein Binding
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Cell Communication
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Protein Folding Chaperone Complex
Negative Regulation Of Intracellular Signal Transduction
Response To Heat
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Biosynthetic Process
Regulation Of Gene Expression
Positive Regulation Of Catabolic Process
Nucleus
Response To Peptide
Positive Regulation Of Protein Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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