EPS8 and XAGE2

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		EPS8	XAGE2
Description		EGFR pathway substrate 8, signaling adaptor	X antigen family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3	7 interacting genes: EHMT2 EPS8 FOXP4 GMCL1 GMCL2 POT1 TERF2IP
Entrez ID		2059	9502
HPRD ID		02563	02332
Ensembl ID		ENSG00000151491	ENSG00000155622
Uniprot IDs		B4E3T6 Q12929	Q96GT9
PDB IDs		2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium	Nuclear Telomere Cap Complex Shelterin Complex G-rich Strand Telomeric DNA Binding Telomere Capping Telomere Maintenance Via Telomerase Germ Cell Development RNA-templated DNA Biosynthetic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Cellular Component Organization Negative Regulation Of Telomere Maintenance Chromosome Organization Histone H3K56 Methyltransferase Activity Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Negative Regulation Of Chromosome Organization DNA Biosynthetic Process Regulation Of Organelle Organization Regulation Of DNA Metabolic Process Positive Regulation Of Telomeric Loop Disassembly Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of DNA Recombination At Telomere Phenotypic Switching 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomere Organization Nuclear Matrix Negative Regulation Of DNA Metabolic Process Adult Behavior Regulation Of Double-strand Break Repair Telomeric D-loop Binding Telomere Assembly Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peptidyl-lysine Dimethylation Chromosome Single-stranded Telomeric DNA Binding Chromosome, Telomeric Region Histone H3K27 Methyltransferase Activity Actin Polymerization-dependent Cell Motility Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Protection From Non-homologous End Joining At Telomere Histone H3K9me2 Methyltransferase Activity DEAD/H-box RNA Helicase Binding NMDA Selective Glutamate Receptor Complex Behavioral Response To Ethanol
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