EPS8 and ALDH7A1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		EPS8	ALDH7A1
Gene Name		epidermal growth factor receptor pathway substrate 8	aldehyde dehydrogenase 7 family, member A1
Image
Gene Ontology Annotations	Cellular Component	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Extracellular Vesicular Exosome
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding	Aldehyde Dehydrogenase (NAD) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility	Cellular Aldehyde Metabolic Process Lysine Catabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Lysine catabolism Metabolism of amino acids and derivatives
Drugs			NADH
Diseases
GWAS		Protein quantitative trait loci ( 18464913)	Osteoporosis ( 20072603)
Protein-Protein Interactions		54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3	3 interactors: APP EPS8 RECQL5
Entrez ID		2059	501
HPRD ID		02563	00124
Ensembl ID		ENSG00000151491	ENSG00000164904
Uniprot IDs		B4DX66 B4E3T6 Q12929	P49419
PDB IDs		2E8M	2J6L
Enriched GO Terms of Interacting Partners?		Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor	Adult Locomotory Behavior Adult Behavior Synaptic Growth At Neuromuscular Junction Locomotory Behavior Collateral Sprouting In Absence Of Injury Actin Polymerization-dependent Cell Motility Mitotic Nuclear Division Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Exit From Mitosis Single-organism Behavior Neuron Remodeling Behavioral Response To Ethanol Behavior Rac Protein Signal Transduction Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Copper Ion Homeostasis Negative Regulation Of DNA-templated Transcription, Elongation Mitotic Cell Cycle Process Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Chromosome Separation Copper Ion Homeostasis Suckling Behavior Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Transcription Elongation From RNA Polymerase II Promoter RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cell Cycle Process Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle Actin Filament Capping Regulation Of Cell Cycle G2/M Phase Transition Axon Cargo Transport Mating Neuromuscular Junction Development Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Actin Filament Depolymerization Neuron Apoptotic Process
Tagcloud ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	accumulating aldehyde associate carcinomas clearly counterparts dehydrogense demonstrates dramatic du145 elevation former glands isoforms local metastatic paired pc pcscs pin prostate robust stained tumorigenesis tumours xenograft
Tagcloud (Difference) ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	accumulating aldehyde associate carcinomas clearly counterparts dehydrogense demonstrates dramatic du145 elevation former glands isoforms local metastatic paired pc pcscs pin prostate robust stained tumorigenesis tumours xenograft
Tagcloud (Intersection) ?