EPS8 and BCKDK

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EPS8	BCKDK
Gene Name		epidermal growth factor receptor pathway substrate 8	branched chain ketoacid dehydrogenase kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome	Mitochondrion Mitochondrial Alpha-ketoglutarate Dehydrogenase Complex
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity [3-methyl-2-oxobutanoate Dehydrogenase (acetyl-transferring)] Kinase Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility	Protein Phosphorylation Cellular Amino Acid Catabolic Process Branched-chain Amino Acid Catabolic Process Phosphorylation
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3	6 interactors: APP EPS8 LSM8 NR5A2 STAT3 TRAF4
Entrez ID		2059	10295
HPRD ID		02563	12523
Ensembl ID		ENSG00000151491	ENSG00000103507
Uniprot IDs		B4DX66 B4E3T6 Q12929	A8MY43 O14874 Q96G95
PDB IDs		2E8M
Enriched GO Terms of Interacting Partners?		Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor	Intracellular Receptor Signaling Pathway Feeding Behavior Regulation Of Multicellular Organism Growth Behavior Adult Locomotory Behavior Synaptic Growth At Neuromuscular Junction Response To Ethanol Regulation Of Protein Binding Adult Behavior Collateral Sprouting In Absence Of Injury Actin Polymerization-dependent Cell Motility Chemical Homeostasis Collateral Sprouting Axon Midline Choice Point Recognition Locomotory Behavior Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Transcription From RNA Polymerase II Promoter Axon Choice Point Recognition Exit From Mitosis Steroid Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Binding Negative Regulation Of Glycolytic Process Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Regulation Of Signal Transduction Neuron Remodeling Radial Glial Cell Differentiation Behavioral Response To Ethanol Positive Regulation Of Protein Homodimerization Activity Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Cell Development Positive Regulation Of Transcription, DNA-templated Organ Development Homeostatic Process Regulation Of Signaling Interleukin-6-mediated Signaling Pathway Signaling Cell Communication RNA Metabolic Process Rac Protein Signal Transduction Movement Of Cell Or Subcellular Component Positive Regulation Of Macromolecule Biosynthetic Process MRNA Processing Cellular Copper Ion Homeostasis Positive Regulation Of Gene Expression Regulation Of Protein Homodimerization Activity Positive Regulation Of Metabolic Process Single-organism Behavior
Tagcloud ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	administering afforded akt3 ameliorated asd autism autisms clues cntn5 cntnap2 cyfip1 en2 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1
Tagcloud (Difference) ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	administering afforded akt3 ameliorated asd autism autisms clues cntn5 cntnap2 cyfip1 en2 fmr1 individually mecp2 neuroanatomical neuroligins neurorexins personalized pharmacologic phenotypically plausible polygenic scn1a shank2 siblings slc6a4 tailored tsc1
Tagcloud (Intersection) ?