EPS8 and BLOC1S6

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EPS8	BLOC1S6
Gene Name		epidermal growth factor receptor pathway substrate 8	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Endosome Cytosol Extrinsic Component Of Membrane Transport Vesicle BLOC-1 Complex SNARE Complex
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding	Protein Binding Syntaxin Binding Identical Protein Binding Protein Homodimerization Activity Actin Filament Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility	Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Synaptic Vesicle Docking Melanocyte Differentiation Neuron Projection Development Melanosome Transport Melanosome Organization Positive Regulation Of Natural Killer Cell Activation Secretion Of Lysosomal Enzymes Endosome To Melanosome Transport Anterograde Synaptic Vesicle Transport Positive Regulation Of Pigment Cell Differentiation Membrane Organization Membrane Fusion
Pathways			Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3	38 interactors: ABI2 AGGF1 ANK1 APP BLOC1S1 BLOC1S2 BLOC1S4 CCDC136 CCDC22 CCDC53 CCHCR1 CDK5R1 CORO6 DCTN2 DTNBP1 EPS8 EXOC8 HAUS1 IFT20 KRT13 LURAP1 MED21 NDC80 NDN NUP62 OLFM2 PLEKHA5 PLEKHF2 RABGEF1 SKA1 SLC4A1 SMN2 SNAPIN STX11 STX12 SYCE3 TPM3 WDYHV1
Entrez ID		2059	26258
HPRD ID		02563	16055
Ensembl ID		ENSG00000151491	ENSG00000104164
Uniprot IDs		B4DX66 B4E3T6 Q12929	B3KY40 Q9UL45
PDB IDs		2E8M
Enriched GO Terms of Interacting Partners?		Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor	Anterograde Synaptic Vesicle Transport Establishment Of Localization In Cell Axon Cargo Transport Melanosome Organization Pigment Granule Organization Organelle Organization Cellular Pigmentation Anterograde Axon Cargo Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Cellular Localization Organelle Localization Synaptic Vesicle Transport Movement Of Cell Or Subcellular Component Establishment Of Vesicle Localization Intracellular Transport Pigmentation Vesicle Organization Establishment Of Organelle Localization Vesicle Localization Membrane Organization Neuron Development Microtubule-based Process Neuron Projection Development Platelet Dense Granule Organization Microtubule-based Movement Cytoskeleton Organization Neuron Differentiation Cell Projection Organization Vesicle-mediated Transport Protein Localization Protein Transport Establishment Of Protein Localization Cell Development Post-Golgi Vesicle-mediated Transport Generation Of Neurons Cellular Protein Localization Neurogenesis Neuron Recognition Secretory Granule Organization Transport Endomembrane System Organization Golgi Vesicle Transport Vesicle Fusion Nervous System Development Mitotic Nuclear Division Secretion By Cell Synaptic Vesicle Fusion To Presynaptic Membrane Exocytosis Organelle Fusion
Tagcloud ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Difference) ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound
Tagcloud (Intersection) ?