ABI1 and TRIP10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ABI1	TRIP10
Description		abl interactor 1	thyroid hormone receptor interactor 10
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Filopodium Growth Cone SCAR Complex Cell Leading Edge Filopodium Tip Cell Projection Neuron Projection Synapse Extracellular Exosome Actin-based Cell Projection	Phagocytic Cup Nucleoplasm Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Membrane Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Somitogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Megakaryocyte Development Dendrite Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Endocytosis Cell Communication Signal Transduction Actin Cytoskeleton Organization
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Clathrin-mediated endocytosis RHOQ GTPase cycle
Drugs
Diseases
GWAS
Interacting Genes		67 interacting genes: ABL1 AKT1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2	43 interacting genes: ABI1 ABL2 AKAP9 ARHGAP12 ARHGAP17 CDC42 CREBBP CTNNB1 DNM2 DTX3 HOXC11 HTT JRK LYN MEOX1 MEOX2 NKX2-5 PAX6 PDE6G POT1 PRKACA RHOJ RHOQ RIN1 RXRA SF3A2 SH3BP1 SHANK3 SMARCE1 SMURF1 SRC STAT3 TERF1 THAP1 THRB TINF2 UTF1 WAS WASF1 WASL WBP11 WWP2 ZBTB7B
Entrez ID		10006	9322
HPRD ID		04336	05142
Ensembl ID		ENSG00000136754	ENSG00000125733
Uniprot IDs		A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0	Q15642 W4VSQ9
PDB IDs		7LXE	2CT4 2EFK 2KE4
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Cytoskeleton Organization Actin Binding Cell Projection Regulation Of Actin Filament Length Regulation Of Cellular Component Size Cell Projection Organization Cytoskeleton Organization Regulation Of Actin Filament Polymerization Lamellipodium Postsynaptic Density Regulation Of Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Organelle Organization Cytoplasm Supramolecular Fiber Organization SCAR Complex Protein Binding Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Translational Initiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Cadherin Binding Synapse Positive Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Actin Filament Polymerization Organelle Organization Cytoskeleton Cytosol Rac Protein Signal Transduction Negative Regulation Of Supramolecular Fiber Organization Actin Polymerization Or Depolymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anchoring Junction Positive Regulation Of Cellular Component Biogenesis SH3 Domain Binding Positive Regulation Of Cellular Component Organization Cell Cortex Profilin Binding	Positive Regulation Of Cellular Component Organization Actin Filament Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Supramolecular Fiber Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Organelle Organization SH3 Domain Binding Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Cell Projection Organization Shelterin Complex Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Signal Transduction Regulation Of Cell Projection Organization Transcription By RNA Polymerase II Actin Filament-based Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Transmembrane Transporter Binding Nuclear Telomere Cap Complex Developmental Process Regulation Of Actin Cytoskeleton Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Telomere Maintenance Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of Primary Metabolic Process Telomere Capping Signal Transduction Positive Regulation Of Organelle Organization Regulation Of Actin Filament-based Process Positive Regulation Of Signal Transduction Establishment Of Organelle Localization Regulation Of Telomere Maintenance Via Telomerase Regulation Of Cytoskeleton Organization Membrane Invagination Ectoderm Development Regulation Of Cell Communication Regulation Of Signaling Cell Projection Morphogenesis Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette
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