ABI1 and NCK2

Number of citations of the paper that reports this interaction (PMID 11557983)
72

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		ABI1	NCK2
Gene Name		abl-interactor 1	NCK adaptor protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Cell Junction Filopodium Growth Cone SCAR Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Cytoplasm Endoplasmic Reticulum Cytosol Vesicle Membrane
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Tyrosine Kinase Activator Activity Protein Complex Binding	SH3/SH2 Adaptor Activity Protein Binding Cytoskeletal Adaptor Activity Receptor Signaling Complex Scaffold Activity
	Biological Process	Somitogenesis Movement Of Cell Or Subcellular Component Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Regulation Of Translation Actin Filament Organization Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor-activated Receptor Activity Axon Guidance Negative Regulation Of Cell Proliferation Positive Regulation Of Signal Transduction Cell Migration Lamellipodium Assembly Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of T Cell Proliferation T Cell Activation Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Signaling by PDGF Ephrin signaling Axon guidance Activation of Rac Signaling by VEGF Downstream signal transduction EPH-Ephrin signaling Nephrin interactions Signaling by Robo receptor VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Addiction ( 23533358)
Protein-Protein Interactions		27 interactors: ABL1 APBB1 CACNA1A CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2	80 interactors: ABI1 ABI2 ABI3 ARHGAP32 ATN1 AXIN1 AXL BCL11A CBLB CCDC33 CD3E CHN1 CPSF6 CPSF7 DDR1 DNM1 DOCK1 DOK1 DRAP1 DVL1 EEF1G EFHC2 EFNB1 EFNB2 EGFR EIF3H ERBB2 ERBB3 FAM53C FASLG FCRL2 FGFR1 FXR2 HNRNPK HOMEZ HOXC4 ILK IRS1 KHDRBS1 KIAA1217 LCP2 LIMS1 LNX1 LRRIQ3 LZTS2 MAGEA6 MASP1 MEOX2 NCKIPSD NPHS1 NR5A1 NTRK2 PAK1 PDGFRB PKN2 PRR20A PSMD10 PTK2 RASSF7 RBM26 REL SF3B4 SORBS2 SOS1 SPRY2 SRPK1 SRPK2 SYNPO TCF4 TNR TRIM27 TRIM41 TRIP6 VARS2 VPS37B WAS WASL WBP11 WIPF2 ZBTB7B
Entrez ID		10006	8440
HPRD ID		04336	05378
Ensembl ID		ENSG00000136754	ENSG00000071051
Uniprot IDs		B6VEX3 B6VEX4 B6VEX5 Q8IZP0	E7ERP6 O43639
PDB IDs			1U5S 1WX6 1Z3K 2B86 2CIA 2FRW 2FRY 2JXB 4E6R
Enriched GO Terms of Interacting Partners?		Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Differentiation Neuron Development Locomotion Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Axonogenesis Neuron Differentiation Regulation Of Actin Filament-based Process Axon Development Actin Cytoskeleton Organization Chemotaxis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoskeleton Organization Cell Development Actin Filament Organization Generation Of Neurons Neurogenesis Anatomical Structure Morphogenesis Nervous System Development Regulation Of Actin Filament Length Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Immune Response-regulating Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization System Development Rac Protein Signal Transduction Cell Differentiation Fc Receptor Signaling Pathway Multicellular Organismal Development Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Actin Polymerization Or Depolymerization Anatomical Structure Development	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Signal Transduction Positive Regulation Of Signal Transduction Immune Response-regulating Signaling Pathway Signaling Movement Of Cell Or Subcellular Component Cell Communication Immune Response Locomotion Regulation Of Immune Response Regulation Of Immune System Process Cell Surface Receptor Signaling Pathway Defense Response Peptidyl-tyrosine Phosphorylation Axon Guidance Intracellular Signal Transduction Cell Migration Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Anatomical Structure Development Positive Regulation Of Protein Metabolic Process Cell Development Gene Expression Regulation Of Cellular Process Immune System Process Cell Motility System Development Anatomical Structure Morphogenesis Regulation Of Cell Proliferation Multicellular Organismal Development Chemotaxis Cell Morphogenesis Involved In Differentiation Axonogenesis Regulation Of Protein Metabolic Process Neuron Projection Morphogenesis Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Metabolic Process Axon Development Developmental Process Response To Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurogenesis Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development
Tagcloud ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Difference) ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	accumulates adapter atr becoming cleavage coordination cytoskeletal depleted depletion discrete hela hyperactive increasingly interconnectedness interconnectivity irradiation monitored mostly nck1 parp phenocopies redundant shortly socs7 strikingly translocation undergo uv
Tagcloud (Intersection) ?