ABI1 and DST

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ABI1	DST
Description		abl interactor 1	dystonin
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GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Filopodium Growth Cone SCAR Complex Cell Leading Edge Filopodium Tip Cell Projection Neuron Projection Synapse Extracellular Exosome Actin-based Cell Projection	Stress Fiber Basement Membrane Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Microtubule Intermediate Filament Plasma Membrane Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Membrane Z Disc Hemidesmosome Axon Cell Leading Edge Cytoplasmic Vesicle H Zone Microtubule Plus-end Cell Projection Intermediate Filament Cytoskeleton Anchoring Junction Cell Periphery Polymeric Cytoskeletal Fiber Axon Cytoplasm
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding	Actin Binding Integrin Binding Structural Molecule Activity Calcium Ion Binding Protein Binding Microtubule Binding Protein Homodimerization Activity Metal Ion Binding Microtubule Plus-end Binding
	Biological Process	Somitogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Megakaryocyte Development Dendrite Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Adhesion Integrin-mediated Signaling Pathway Retrograde Axonal Transport Response To Wounding Maintenance Of Cell Polarity Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization Cell Motility
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Type I hemidesmosome assembly RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases
GWAS			Alzheimer disease and age of onset ( 26830138) Appendicular lean mass ( 33097823) Attention function in attention deficit hyperactive disorder ( 26174813) Cerebrospinal fluid clusterin levels ( 26545630) Daytime sleep phenotypes ( 27126917) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Red blood cell count ( 32888494) Small cell lung carcinoma ( 28604730)
Interacting Genes		67 interacting genes: ABL1 AKT1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2	50 interacting genes: ABI1 ANKRD1 APC C1QTNF9 CALM1 CDC5L CELSR3 CEP63 CLIP4 COL17A1 DCTN1 DISC1 DSCAM DSCR9 DTNBP1 ECPAS EIF4ENIF1 ERBB2 ERBIN EXOC1 FTCD HUNK ITGB4 ITSN1 ITSN2 KIAA1549 KRT14 KRT5 LINC01554 MAPK6 MORC3 MTNR1B MYBPC2 NFYC NRIP1 PAK2 PCNT PRKAB2 PRKD2 PTGER4 RBM11 RSPH1 SH3BP5 SMAD9 SNAPIN TNIK TRAF3IP1 TTC3 TULP3 USP7
Entrez ID		10006	667
HPRD ID		04336	00222
Ensembl ID		ENSG00000136754	ENSG00000151914
Uniprot IDs		A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0	A0A7P0T890 B4DGY0 B4DSS9 E9PHM6 F6QMI7 F8W9J4 Q03001 Q6P0N6
PDB IDs		7LXE	3GJO 7OLG
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Cytoskeleton Organization Actin Binding Cell Projection Regulation Of Actin Filament Length Regulation Of Cellular Component Size Cell Projection Organization Cytoskeleton Organization Regulation Of Actin Filament Polymerization Lamellipodium Postsynaptic Density Regulation Of Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Organelle Organization Cytoplasm Supramolecular Fiber Organization SCAR Complex Protein Binding Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Translational Initiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Cadherin Binding Synapse Positive Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Actin Filament Polymerization Organelle Organization Cytoskeleton Cytosol Rac Protein Signal Transduction Negative Regulation Of Supramolecular Fiber Organization Actin Polymerization Or Depolymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anchoring Junction Positive Regulation Of Cellular Component Biogenesis SH3 Domain Binding Positive Regulation Of Cellular Component Organization Cell Cortex Profilin Binding	Signal Transduction Hemidesmosome Cytoskeleton Organization Intracellular Signal Transduction Clathrin-dependent Synaptic Vesicle Endocytosis Regulation Of Dendritic Spine Development Plasma Membrane Bounded Cell Projection Organization Cell Projection Organization Centrosome Developmental Process Cytosol Hemidesmosome Assembly Cytoplasm Vesicle-mediated Transport In Synapse Organelle Organization Molecular Adaptor Activity Anatomical Structure Morphogenesis Cytoskeleton Regulation Of Neuron Projection Development Ciliary Base Presynaptic Endocytosis Cellular Component Assembly Cell Junction Organization Dendrite Morphogenesis Cell Surface Receptor Signaling Pathway Protein Binding Microtubule-based Process Protein Phosphorylation Plasma Membrane Bounded Cell Projection Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Titin Binding Nucleoplasm Cell Junction Assembly Regulation Of Cell Projection Organization Cell Projection Assembly Cell Leading Edge Cilium Assembly Axonal Transport Organelle Assembly Neuron Cellular Homeostasis Dendritic Spine Development Neuron Projection Morphogenesis Phosphorylation Basal Plasma Membrane Protein Tyrosine Kinase Activator Activity Embryonic Camera-type Eye Development Negative Regulation Of Interferon-beta Production Anterograde Synaptic Vesicle Transport BLOC-1 Complex Positive Regulation Of Cell Growth
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