EPS8 and ADAM22

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EPS8	ADAM22
Gene Name		epidermal growth factor receptor pathway substrate 8	ADAM metallopeptidase domain 22
Image
Gene Ontology Annotations	Cellular Component	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome	Integral Component Of Membrane Axon
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3	5 interactors: EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		2059	53616
HPRD ID		02563	04751
Ensembl ID		ENSG00000151491	ENSG00000008277
Uniprot IDs		B4DX66 B4E3T6 Q12929	Q08AL8 Q9P0K1
PDB IDs		2E8M	3G5C
Enriched GO Terms of Interacting Partners?		Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor	Cellular Component Assembly Regulation Of Cellular Component Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Locomotion Regulation Of Signaling Axon Guidance Positive Regulation Of Mitochondrion Organization Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Mitochondrion Organization Chemotaxis Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Organelle Organization Actin Polymerization-dependent Cell Motility Intrinsic Apoptotic Signaling Pathway Neuron Development Platelet Activation Positive Regulation Of Apoptotic Signaling Pathway Golgi Reassembly Ras Protein Signal Transduction Cell Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Neuron Differentiation Cell Projection Organization Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Establishment Of Golgi Localization Exit From Mitosis Positive Regulation Of Signal Transduction Golgi Inheritance Actin Filament Organization Behavioral Response To Ethanol Histamine Secretion Apoptotic Signaling Pathway Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Histamine Transport
Tagcloud ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	4pba abnormally adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure
Tagcloud (Difference) ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	4pba abnormally adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure
Tagcloud (Intersection) ?