EPS8 and RFXAP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EPS8	RFXAP
Gene Name		epidermal growth factor receptor pathway substrate 8	regulatory factor X-associated protein
Image
Gene Ontology Annotations	Cellular Component	Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Cell Junction Growth Cone Vesicle Stereocilium Ruffle Membrane Extracellular Vesicular Exosome	Nucleus
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Protein Binding Rac GTPase Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity
	Biological Process	Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cell Proliferation Adult Locomotory Behavior Regulation Of Cell Shape Positive Regulation Of Signal Transduction Exit From Mitosis Rac Protein Signal Transduction Regulation Of Actin Filament Length Actin Cytoskeleton Reorganization Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility	Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Protein quantitative trait loci ( 18464913)
Protein-Protein Interactions		54 interactors: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BYSL C17orf59 C19orf25 C8orf33 CASK CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RFXAP RUNX1T1 SCRN3 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XRCC6 ZZZ3	4 interactors: EPS8 RFX5 RFXANK SMARCA4
Entrez ID		2059	5994
HPRD ID		02563	03515
Ensembl ID		ENSG00000151491	ENSG00000133111
Uniprot IDs		B4DX66 B4E3T6 Q12929	O00287
PDB IDs		2E8M	2KW3
Enriched GO Terms of Interacting Partners?		Cell Differentiation Developmental Process Movement Of Cell Or Subcellular Component Multicellular Organismal Development System Development Anatomical Structure Development Cell Projection Morphogenesis Cell Part Morphogenesis Axonogenesis Axon Guidance Fc Receptor Signaling Pathway Axon Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Anatomical Structure Morphogenesis Chemotaxis Neurogenesis Neuron Projection Development Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Organelle Organization Positive Regulation Of Signal Transduction Cell Morphogenesis Leukocyte Migration Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Generation Of Neurons Cell Development Response To External Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Morphogenesis Involved In Differentiation Neuron Development Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Body Fluid Levels Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Coagulation Fibroblast Growth Factor Receptor Signaling Pathway Hemostasis Regulation Of ERBB Signaling Pathway Nervous System Development Innate Immune Response Anatomical Structure Formation Involved In Morphogenesis Regulation Of Protein Phosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Phosphorylation Regulation Of Immune System Process Platelet Activation Response To Fibroblast Growth Factor	Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Actin Polymerization-dependent Cell Motility Ras Protein Signal Transduction DNA Methylation On Cytosine Within A CG Sequence Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Exit From Mitosis Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Behavioral Response To Ethanol Positive Regulation By Host Of Viral Transcription Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation On Cytosine Negative Regulation Of Androgen Receptor Signaling Pathway Nucleosome Disassembly Blastocyst Hatching Rac Protein Signal Transduction Heart Trabecula Formation Lens Fiber Cell Development Vascular Smooth Muscle Cell Differentiation Transcription, DNA-templated Regulation Of Androgen Receptor Signaling Pathway Barbed-end Actin Filament Capping Actin Crosslink Formation Dendritic Cell Migration Glial Cell Fate Commitment RNA Biosynthetic Process Small GTPase Mediated Signal Transduction Definitive Hemopoiesis Heart Trabecula Morphogenesis Blastocyst Growth Interaction With Symbiont Chromatin Silencing Lens Fiber Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Binding Epidermis Morphogenesis Histone H3 Acetylation Positive Regulation Of Viral Transcription Actin Filament Capping Trabecula Morphogenesis Embryonic Hindlimb Morphogenesis Cell Fate Determination Skin Morphogenesis RNA Metabolic Process Neural Retina Development Smooth Muscle Cell Differentiation Negative Regulation Of Actin Filament Depolymerization Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Tagcloud ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfx5 rfxank tight transactivates w x1 x2
Tagcloud (Difference) ?		adjacent breast cadherin cisplatin colony ectopic egf emt erk filopodia g418 healing invasive knockdown lentiviral mb231 mb468 mcf7 mda mmp9 mtt overexpressed possibly shrna stably transition vimentin weakly wound	ankyrin assembles associate associates atf1 class coactivators coimmunoprecipitation compose cooperate enhanceosome leucine mhc module nlr nlrc5 nonderepressible nucleoprotein participates promoters repeats rfx5 rfxank tight transactivates w x1 x2
Tagcloud (Intersection) ?