EPS8 and PCM1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EPS8	PCM1
Description		EGFR pathway substrate 8, signaling adaptor	pericentriolar material 1
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Protein Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)	Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)
Interacting Genes		61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3	57 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PPIE PRC1 PRKCI PRPF6 RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TTC8 VPS26C WASHC3 ZNF830
Entrez ID		2059	5108
HPRD ID		02563	02624
Ensembl ID		ENSG00000151491	ENSG00000078674
Uniprot IDs		B4E3T6 Q12929	A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154
PDB IDs		2E8M 7TZK	6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium	Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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