EPS8 and PROSER2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		EPS8	PROSER2
Description		EGFR pathway substrate 8, signaling adaptor	proline and serine rich 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Actin Binding Protein Binding Small GTPase Binding	Protein Binding
	Biological Process	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)	Fractures (paediatric) ( 32742401) Mean platelet volume ( 27863252)
Interacting Genes		61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3	6 interacting genes: ACTB APP CLIC3 EPS8 POT1 YTHDC1
Entrez ID		2059	254427
HPRD ID		02563	10697
Ensembl ID		ENSG00000151491	ENSG00000148426
Uniprot IDs		B4E3T6 Q12929	D3DRR9 Q86WR7
PDB IDs		2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium	Brush Border Cellular Component Assembly Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Amyloid-beta Complex Growth Cone Lamellipodium Adult Locomotory Behavior Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Stress Regulation Of Transepithelial Transport Chromatin Remodeling Axonogenesis Regulation Of Norepinephrine Uptake Transporter Regulator Activity Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Endosome To Plasma Membrane Transport Vesicle Adult Behavior Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Growth Cone Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Protein-disulfide Reductase (glutathione) Activity Positive Regulation Of Telomeric Loop Disassembly 8-hydroxy-2'-deoxyguanosine DNA Binding Telomeric G-quadruplex DNA Binding Telomeric D-loop Binding Telomere Assembly Primary Follicle Stage Mammalian Oogenesis Stage MRNA Alternative Polyadenylation Vesicle Protein Localization To Adherens Junction
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