ABI1 and SORBS1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ABI1	SORBS1
Description		abl interactor 1	sorbin and SH3 domain containing 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Filopodium Growth Cone SCAR Complex Cell Leading Edge Filopodium Tip Cell Projection Neuron Projection Synapse Extracellular Exosome Actin-based Cell Projection	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction
	Molecular Function	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity Cadherin Binding	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Somitogenesis Neuron Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Megakaryocyte Development Dendrite Morphogenesis Cell Projection Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Smooth Muscle Contraction
Drugs
Diseases
GWAS			Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		67 interacting genes: ABL1 AKT1 APBB1 C22orf15 CACNA1A CCDC57 CCHCR1 CYFIP2 DST DTNB EIF3H ENAH ENKD1 EPS8 EPS8L1 EVL FAM124B FBXL19 FHL2 FXR1 GAS7 HHEX HNRNPK HOMER1 HOMER3 HSPA8 KIAA0408 KIAA1217 KTN1 LMO1 MAB21L2 MINK1 MRFAP1 MRFAP1L1 NCK1 NCK2 NCKAP1 NEB NFASC NIN OGT PAK2 PCM1 PRKAA2 PRPF40A RBM15 RCOR3 SHANK3 SMARCD1 SORBS1 SORBS2 SOS1 SOS2 SPTA1 SPTAN1 SRP68 SRRM1 SYNE2 TCERG1 TLN1 TRIP10 TSC1 TTC23 VARS2 VASP WASF1 WASF2	31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL
Entrez ID		10006	10580
HPRD ID		04336	05587
Ensembl ID		ENSG00000136754	ENSG00000095637
Uniprot IDs		A0A0A0MRT6 B6VEX3 B6VEX4 B6VEX5 Q8IZP0	A0A3B3IRW8 B4DTX5 Q9BX66
PDB IDs		7LXE	2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?		Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament-based Process Focal Adhesion Regulation Of Cytoskeleton Organization Actin Binding Cell Projection Regulation Of Actin Filament Length Regulation Of Cellular Component Size Cell Projection Organization Cytoskeleton Organization Regulation Of Actin Filament Polymerization Lamellipodium Postsynaptic Density Regulation Of Actin Polymerization Or Depolymerization Actin Filament Organization Actin Filament-based Process Actin Cytoskeleton Organization Regulation Of Organelle Organization Cytoplasm Supramolecular Fiber Organization SCAR Complex Protein Binding Regulation Of Protein-containing Complex Assembly Plasma Membrane Bounded Cell Projection Organization Regulation Of Translational Initiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cellular Component Organization Postsynapse Regulation Of Cell Projection Organization Positive Regulation Of Supramolecular Fiber Organization Cadherin Binding Synapse Positive Regulation Of Cytoskeleton Organization Lamellipodium Organization Positive Regulation Of Actin Filament Polymerization Organelle Organization Cytoskeleton Cytosol Rac Protein Signal Transduction Negative Regulation Of Supramolecular Fiber Organization Actin Polymerization Or Depolymerization Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Anchoring Junction Positive Regulation Of Cellular Component Biogenesis SH3 Domain Binding Positive Regulation Of Cellular Component Organization Cell Cortex Profilin Binding	SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone
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