ABI1 and SPTAN1

Number of citations of the paper that reports this interaction (PMID 9593709)
24

Data Source:
HPRD (in vitro, two hybrid)

		ABI1	SPTAN1
Gene Name		abl-interactor 1	spectrin, alpha, non-erythrocytic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Cytosol Cytoskeleton Postsynaptic Density Lamellipodium Cell Junction Filopodium Growth Cone SCAR Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Cytoskeletal Protein Binding Protein Tyrosine Kinase Activator Activity Protein Complex Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Somitogenesis Movement Of Cell Or Subcellular Component Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Actin Polymerization Or Depolymerization Negative Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation Megakaryocyte Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Lamellipodium Morphogenesis	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways		Signaling by VEGF Fcgamma receptor (FCGR) dependent phagocytosis VEGFA-VEGFR2 Pathway Regulation of actin dynamics for phagocytic cup formation Innate Immune System	Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS
Protein-Protein Interactions		27 interactors: ABL1 APBB1 CACNA1A CYFIP2 ENAH EPS8 EPS8L1 EVL GAS7 HSPA8 MINK1 NCK1 NCK2 NCKAP1 NEB NIN PAK2 PRPF40A SOS1 SOS2 SPTA1 SPTAN1 SRRM1 TCERG1 VASP WASF1 WASF2	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		10006	6709
HPRD ID		04336	01684
Ensembl ID		ENSG00000136754	ENSG00000197694
Uniprot IDs		B6VEX3 B6VEX4 B6VEX5 Q8IZP0	Q13813
PDB IDs			2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Neuron Projection Morphogenesis Cell Projection Morphogenesis Cell Part Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Movement Of Cell Or Subcellular Component Neuron Projection Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Differentiation Neuron Development Locomotion Actin Filament-based Process Regulation Of Actin Cytoskeleton Organization Axonogenesis Neuron Differentiation Regulation Of Actin Filament-based Process Axon Development Actin Cytoskeleton Organization Chemotaxis Regulation Of Cellular Component Organization Regulation Of Cytoskeleton Organization Cytoskeleton Organization Cell Development Actin Filament Organization Generation Of Neurons Neurogenesis Anatomical Structure Morphogenesis Nervous System Development Regulation Of Actin Filament Length Regulation Of Organelle Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Actin Filament Polymerization Immune Response-regulating Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Regulation Of Cellular Component Size Regulation Of Actin Polymerization Or Depolymerization System Development Rac Protein Signal Transduction Cell Differentiation Fc Receptor Signaling Pathway Multicellular Organismal Development Organelle Organization Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Immune System Process Actin Polymerization Or Depolymerization Anatomical Structure Development	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?		aba abl1 abscisic advantage arabidopsis assayed character contrary copies defense dormancy drought implicates lap le25 meja mrnas pin2 proteinase requisite seed signalling tas14 tomato transcripts transformants wilty wound wounding	adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?