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CHEK2 and PPP2R5A
Number of citations of the paper that reports this interaction (PMID
15380617
)
16
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
CHEK2
PPP2R5A
Gene Name
checkpoint kinase 2
protein phosphatase 2, regulatory subunit B, alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleoplasm
Golgi Apparatus
PML Body
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Nucleus
Cytoplasm
Membrane
Z Disc
M Band
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Kinase Binding
Biological Process
DNA Damage Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Double-strand Break Repair
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Regulation Of Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Cellular Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Protein Stabilization
Cell Division
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Mitotic Spindle Assembly
Replicative Senescence
Signal Transduction
Positive Regulation Of Protein Dephosphorylation
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Negative Regulation Of Lipid Kinase Activity
Pathways
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Mitotic Anaphase
Signaling by Wnt
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Degradation of beta-catenin by the destruction complex
S37 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
CTLA4 inhibitory signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Cell Cycle, Mitotic
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Breast size (
22747683
)
Esophageal cancer (squamous cell) (
22960999
)
Esophageal cancer and gastric cancer (
20729852
)
Vertical cup-disc ratio (
20548946
)
Protein-Protein Interactions
47 interactors:
AATF
APP
ARHGAP1
ASF1A
ATM
ATR
BRCA1
BRCA2
CDC25A
CDC25C
DAPK3
DBF4
E2F1
ELAVL1
ERCC6
FOXM1
KPNA2
LATS2
MDC1
MDM2
MDM4
MRC1
MSH2
MUS81
NBN
NR4A1
PLK1
PLK3
POLR2L
PPP2CA
PPP2R2A
PPP2R2B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
PRKDC
RAD9A
RCHY1
REV3L
RNF8
SRPK1
STRAP
TP53
TSSK1B
VHL
18 interactors:
APC
BCL2
BEST1
CHEK2
CSNK1A1
CTLA4
EIF2AK2
GNL3
JAK2
MAPT
NEK1
NOS3
PPP2R1A
PTTG1
PYGM
SGOL1
SHC1
TP63
Entrez ID
11200
5525
HPRD ID
05084
03384
Ensembl ID
ENSG00000183765
ENSG00000066027
Uniprot IDs
O96017
Q15172
PDB IDs
1GXC
2CN5
2CN8
2W0J
2W7X
2WTC
2WTD
2WTI
2WTJ
2XBJ
2XK9
2XM8
2XM9
2YCF
2YCQ
2YCR
2YCS
2YIQ
2YIR
2YIT
3I6U
3I6W
3VA4
4A9R
4A9S
4A9T
4A9U
4BDA
4BDB
4BDC
4BDD
4BDE
4BDF
4BDG
4BDH
4BDI
4BDJ
4BDK
Enriched GO Terms of Interacting Partners
?
Cellular Response To DNA Damage Stimulus
Cell Cycle Process
Cellular Response To Stress
Cell Cycle
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
DNA Damage Checkpoint
Regulation Of Mitotic Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle Checkpoint
Response To Stress
Signal Transduction By P53 Class Mediator
DNA Repair
Regulation Of Cell Cycle Process
Signal Transduction In Response To DNA Damage
Regulation Of Metabolic Process
Response To Stimulus
Mitotic Cell Cycle Checkpoint
DNA Damage Response, Signal Transduction By P53 Class Mediator
Response To Radiation
Negative Regulation Of Cell Cycle
Apoptotic Process
Response To Ionizing Radiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Programmed Cell Death
Mitotic DNA Damage Checkpoint
Regulation Of Protein Metabolic Process
Double-strand Break Repair
Mitotic DNA Integrity Checkpoint
Cell Death
Death
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Intracellular Signal Transduction
Response To Abiotic Stimulus
Signal Transduction
DNA Recombination
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Signaling
Nucleobase-containing Compound Metabolic Process
Cell Communication
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Mitotic Cell Cycle Process
Cell Division
Organelle Organization
Cellular Response To Stress
Mitotic Cell Cycle
Regulation Of Protein Metabolic Process
Mitotic Nuclear Division
Positive Regulation Of Signal Transduction
Cell Cycle Process
Regulation Of Cell Proliferation
Cellular Response To DNA Damage Stimulus
Regulation Of Catalytic Activity
Cell Cycle
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Response To Ionizing Radiation
Apoptotic Process
Positive Regulation Of Cell Death
Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Regulation Of Apoptotic Process
Programmed Cell Death
Regulation Of Phosphorus Metabolic Process
Cell Death
Negative Regulation Of Cell Proliferation
Death
Response To Stress
Regulation Of Protein Phosphorylation
Regulation Of Cell Death
Regulation Of Signal Transduction
Response To Gamma Radiation
Regulation Of Cell Differentiation
Cytoskeleton Organization
Intrinsic Apoptotic Signaling Pathway
Regulation Of Protein Kinase Activity
Positive Regulation Of Apoptotic Signaling Pathway
Response To Radiation
Regulation Of Kinase Activity
Negative Regulation Of Mitotic Cell Cycle
Regulation Of Signaling
Cell Aging
Regulation Of Cell Cycle Phase Transition
Regulation Of Phosphorylation
Protein Phosphorylation
Intracellular Signal Transduction
Negative Regulation Of Osteoblast Proliferation
Positive Regulation Of Microtubule Polymerization
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Activation Of Protein Kinase Activity
Tagcloud
?
alleles
atm
brca1
brca2
brip1
cdh1
confer
contributing
contributive
fashion
hereditary
influences
lifetime
offers
otherwise
palb2
penetrance
penetrant
personal
polygenic
predisposing
predisposition
quite
snp
stk11
suggestive
suspicion
unlikely
venue
Tagcloud (Difference)
?
alleles
atm
brca1
brca2
brip1
cdh1
confer
contributing
contributive
fashion
hereditary
influences
lifetime
offers
otherwise
palb2
penetrance
penetrant
personal
polygenic
predisposing
predisposition
quite
snp
stk11
suggestive
suspicion
unlikely
venue
Tagcloud (Intersection)
?