CHEK2 and PLK3

Number of citations of the paper that reports this interaction (PMID 10973490)
183

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		CHEK2	PLK3
Gene Name		checkpoint kinase 2	polo-like kinase 3
Image
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body	Nucleus Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL	14 interactors: AURKA CDC25C CENPU CHEK2 CIB1 MAP2K1 MAPK1 POU2F1 SNCA SNCB SUMO1 TP53 TRIP13 VRK1
Entrez ID		11200	1263
HPRD ID		05084	04222
Ensembl ID		ENSG00000183765	ENSG00000173846
Uniprot IDs		O96017	Q9H4B4
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	4B6L
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair	Cell Cycle Mitotic Cell Cycle Organelle Organization Regulation Of Cellular Component Organization Regulation Of Organelle Organization Cellular Response To Stress Regulation Of Protein Metabolic Process Mitotic Nuclear Division Cell Cycle Process Regulation Of Protein Stability Positive Regulation Of Cellular Protein Metabolic Process Mitotic Cell Cycle Process Double-strand Break Repair Regulation Of Golgi Inheritance Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Microtubule Polymerization Or Depolymerization Regulation Of Metabolic Process Cell Division Regulation Of Intracellular Transport Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To DNA Damage Stimulus Cellular Metabolic Process Regulation Of Golgi Organization Golgi Inheritance Cell Aging Regulation Of Microtubule Polymerization Or Depolymerization Cellular Response To Growth Factor Stimulus Female Meiosis I DNA Repair Response To Growth Factor Positive Regulation Of Protein Serine/threonine Kinase Activity DNA Metabolic Process Regulation Of Protein Phosphorylation Developmental Process Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Early Endosome To Late Endosome Transport Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Aging Nucleobase-containing Compound Metabolic Process Positive Regulation Of Protein Phosphorylation Peptidyl-serine Phosphorylation Replicative Senescence G2/M Transition Of Mitotic Cell Cycle Regulation Of Protein Kinase Activity Histone-serine Phosphorylation
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue	3a 5mum 5ng annotation correlating crosstalk doxo dusp5 etv7 fc fluoruracil inducer lamp3 log2 mcf7 microenvironment modify nfkappab ntn1 nutlin opposite proof qpcr repressed snai1 synergistically tnfalpha transcriptome unc5b
Tagcloud (Intersection) ?