CHEK2 and KLK9

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		CHEK2	KLK9
Description		checkpoint kinase 2	kallikrein related peptidase 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body	Extracellular Region Extracellular Space Secretory Granule
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Autophagosome Assembly DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Repair Double-strand Break Repair Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Stress Regulation Of Protein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cell Division Thymocyte Apoptotic Process Protein K63-linked Ubiquitination Cellular Response To Xenobiotic Stimulus Cellular Response To Gamma Radiation Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly	Proteolysis Protein Maturation
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs		XL844 Enzastaurin Fostamatinib
Diseases		Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 23535729 29059683) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 28957414 32888494) Smoking initiation ( 33082346) Vertical cup-disc ratio ( 25241763 20548946 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CALM1 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MED1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 PML POLR2L PPM1D PPP1R12A PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL XRCC1	11 interacting genes: APP BAG4 BRMS1 CASP8 CCND1 CHEK2 ESR1 ESR2 PAX2 PTPRJ TGFB1
Entrez ID		11200	284366
HPRD ID		05084	05692
Ensembl ID		ENSG00000183765	ENSG00000213022
Uniprot IDs		A0A7P0MUT5 O96017	Q2XQG6 Q9UKQ9
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Process Nucleoplasm Protein Phosphatase Type 2A Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nucleus Regulation Of Primary Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Double-strand Break Repair DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Metabolic Process Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Regulation Of DNA Metabolic Process Response To Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization Regulation Of DNA Repair G2/M Transition Of Mitotic Cell Cycle Protein Phosphatase Activator Activity Regulation Of Double-strand Break Repair DNA Recombination Mitotic Cell Cycle Phase Transition	Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Response To Estradiol Negative Regulation Of RNA Metabolic Process Negative Regulation Of MiRNA Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Nuclear Estrogen Receptor Activity Negative Regulation Of Metabolic Process Negative Regulation Of RNA Biosynthetic Process Enzyme Binding Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Response To Lipid Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Anoikis Positive Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Morphogenesis Of An Epithelium Positive Regulation Of Apoptotic Process Regulation Of Cell Migration Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Programmed Cell Death Regulation Of MiRNA Transcription Positive Regulation Of Cell Migration Regulation Of Cell Motility Positive Regulation Of Cell Motility Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Locomotion Regulation Of Gene Expression Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Locomotion Estrogen Response Element Binding Regulation Of MiRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Regulation Of Biological Quality Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Branch Elongation Of An Epithelium Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cell Cycle Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Macrophage Differentiation
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