CHEK2 and CRKL

		CHEK2	CRKL
Description		checkpoint kinase 2	CRK like proto-oncogene, adaptor protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Golgi Apparatus PML Body	Nucleoplasm Cytoplasm Cytosol Neuromuscular Junction Protein-containing Complex Synapse Extrinsic Component Of Postsynaptic Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Serine Kinase Activity	Phosphotyrosine Residue Binding RNA Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity Identical Protein Binding Cadherin Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Autophagosome Assembly DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle DNA Repair Double-strand Break Repair Regulation Of DNA-templated Transcription Protein Phosphorylation Apoptotic Process DNA Damage Response Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Mitotic Intra-S DNA Damage Checkpoint Signaling Cellular Response To Stress Regulation Of Protein Catabolic Process Response To Starvation Signal Transduction In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Mitotic DNA Damage Checkpoint Signaling Positive Regulation Of DNA-templated Transcription Protein Autophosphorylation Protein Stabilization Cell Division Thymocyte Apoptotic Process Protein K63-linked Ubiquitination Cellular Response To Xenobiotic Stimulus Cellular Response To Gamma Radiation Mitotic Spindle Assembly Replicative Senescence Regulation Of Signal Transduction By P53 Class Mediator Response To Glycoside Cellular Response To Bisphenol A Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of Anoikis Regulation Of Autophagosome Assembly Positive Regulation Of Autophagosome Assembly	Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Regulation Of Leukocyte Migration Outflow Tract Morphogenesis Lipid Metabolic Process Enzyme-linked Receptor Protein Signaling Pathway JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Pattern Specification Process Heart Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Animal Organ Morphogenesis Anterior/posterior Pattern Specification Regulation Of Gene Expression Negative Regulation Of Gene Expression Dendrite Development Cell Migration Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Migration Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Rac Protein Signal Transduction Intracellular Signal Transduction Helper T Cell Diapedesis Reelin-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Negative Regulation Of SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Response To Fibroblast Growth Factor Endothelin Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Specialization Assembly Cerebellar Neuron Development Cellular Response To Interleukin-7 Chordate Pharynx Development Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration
Pathways		Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL
Drugs		XL844 Enzastaurin Fostamatinib
Diseases		Li-Fraumeni syndrome, including: Classic Li-Fraumeni syndrome (LFS); LFS-like syndrome (LFSL)
GWAS		Alanine aminotransferase levels ( 34315874 33547301) Aspartate aminotransferase levels ( 34315874) Breast cancer ( 23535729 29059683) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Esophageal squamous cell carcinoma ( 25129146) Essential hypertension (time to event) ( 32589924) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Immature fraction of reticulocytes ( 32888494) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung cancer ( 24880342) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Menopause (age at onset) ( 26414677) Myeloproliferative neoplasms ( 33057200) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Optic disc size ( 31809533) Pancreatic cancer ( 25086665) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29117387) Red cell distribution width ( 28957414 32888494) Smoking initiation ( 33082346) Vertical cup-disc ratio ( 25241763 20548946 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Mean platelet volume ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		85 interacting genes: AATF APP ARHGAP1 ASF1A ATM ATR BAALC BEX1 BRCA1 BRCA2 CALM1 CCL5 CDC25A CDC25C CDH13 CDK11B CDKN1A CYP17A1 DAPK3 DBF4 DIRAS3 E2F1 ELAVL1 ENO1 ERCC6 FHL1 FHL3 FOXM1 GNAS HMGN1 HOXC6 ITIH5 KLK7 KLK9 KPNA2 LATS2 LYPD3 MAPT MDC1 MDM2 MDM4 MED1 MRC1 MSH2 MUS81 NBN NR4A1 NSD3 PLK1 PLK3 PML POLR2L PPM1D PPP1R12A PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRDM14 PRKDC PRMT2 PSMC3IP PSME3 RAD9A RCHY1 REV3L RHOBTB2 RNF8 SIAH2 SLC25A6 SRPK1 SRPK2 ST14 STMN1 STRAP TLR3 TP53 TSSK1B USP39 VHL XRCC1	78 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1
Entrez ID		11200	1399
HPRD ID		05084	03596
Ensembl ID		ENSG00000183765	ENSG00000099942
Uniprot IDs		A0A7P0MUT5 O96017	P46109
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK	2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?		Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Intracellular Signal Transduction Negative Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator DNA Damage Response Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Cycle Process Nucleoplasm Protein Phosphatase Type 2A Complex Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Nucleus Regulation Of Primary Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Nucleobase-containing Compound Metabolic Process Response To Ionizing Radiation Double-strand Break Repair DNA Repair Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Macromolecule Metabolic Process DNA Metabolic Process Cellular Response To Stress Intrinsic Apoptotic Signaling Pathway Response To Gamma Radiation Regulation Of DNA Metabolic Process Response To Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Signal Transduction Regulation Of Programmed Cell Death Regulation Of Metabolic Process Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Chromatin Organization Regulation Of DNA Repair G2/M Transition Of Mitotic Cell Cycle Protein Phosphatase Activator Activity Regulation Of Double-strand Break Repair DNA Recombination Mitotic Cell Cycle Phase Transition	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction SH3 Domain Binding Phosphotyrosine Residue Binding Intracellular Signal Transduction Protein Tyrosine Kinase Activity Immune System Process Insulin Receptor Signaling Pathway Cell Activation Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Leukocyte Activation Immune Effector Process ERBB Signaling Pathway B Cell Receptor Signaling Pathway Lymphocyte Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Cytosol Regulation Of Immune System Process B Cell Differentiation Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity B Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of MAPK Cascade Cell Migration Cellular Response To Growth Factor Stimulus Plasma Membrane Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Binding Positive Regulation Of Cellular Component Organization Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway T Cell Activation Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Regulation Of Multicellular Organismal Development Ephrin Receptor Binding Regulation Of Leukocyte Proliferation
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