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CHEK2 and POLR2L
Number of citations of the paper that reports this interaction (PMID
21988832
)
14
Data Source:
BioGRID
(two hybrid)
CHEK2
POLR2L
Gene Name
checkpoint kinase 2
polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleoplasm
Golgi Apparatus
PML Body
Nucleus
Nucleoplasm
DNA-directed RNA Polymerase II, Core Complex
DNA-directed RNA Polymerase III Complex
DNA-directed RNA Polymerase I Complex
Cytosol
Molecular Function
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Homodimerization Activity
Metal Ion Binding
RNA Polymerase I Activity
RNA Polymerase II Activity
RNA Polymerase III Activity
DNA Binding
DNA-directed RNA Polymerase Activity
Zinc Ion Binding
Biological Process
DNA Damage Checkpoint
G2/M Transition Of Mitotic Cell Cycle
Double-strand Break Repair
Transcription, DNA-templated
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Regulation Of Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Cellular Protein Catabolic Process
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Protein Stabilization
Cell Division
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Mitotic Spindle Assembly
Replicative Senescence
MRNA Splicing, Via Spliceosome
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair
Regulation Of Transcription From RNA Polymerase I Promoter
Transcription From RNA Polymerase I Promoter
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription From RNA Polymerase II Promoter
Transcription Initiation From RNA Polymerase II Promoter
Transcription Elongation From RNA Polymerase II Promoter
7-methylguanosine MRNA Capping
Transcription From RNA Polymerase III Promoter
Transcription Elongation From RNA Polymerase III Promoter
Termination Of RNA Polymerase III Transcription
RNA Splicing
Gene Expression
Viral Process
Positive Regulation Of Type I Interferon Production
PiRNA Metabolic Process
Somatic Stem Cell Maintenance
Regulation Of Gene Expression, Epigenetic
Innate Immune Response
Negative Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Viral Transcription
Pathways
RNA Polymerase II Promoter Escape
Formation of HIV-1 elongation complex containing HIV-1 Tat
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Chain Elongation
Abortive elongation of HIV-1 transcript in the absence of Tat
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Regulatory RNA pathways
Tat-mediated elongation of the HIV-1 transcript
Tat-mediated HIV elongation arrest and recovery
Formation of transcription-coupled NER (TC-NER) repair complex
Dual incision reaction in TC-NER
Influenza Life Cycle
RNA Polymerase III Transcription Termination
HIV elongation arrest and recovery
NoRC negatively regulates rRNA expression
Influenza Viral RNA Transcription and Replication
RNA Polymerase III Chain Elongation
RNA Polymerase III Transcription
RNA Polymerase III Transcription Initiation From Type 1 Promoter
mRNA Splicing - Minor Pathway
mRNA Splicing - Major Pathway
MicroRNA (miRNA) biogenesis
Influenza Infection
Pausing and recovery of Tat-mediated HIV elongation
Late Phase of HIV Life Cycle
RNA Polymerase III Transcription Initiation From Type 2 Promoter
Formation of RNA Pol II elongation complex
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Abortive And Retractive Initiation
Transcription of the HIV genome
Nucleotide Excision Repair
PIWI-interacting RNA (piRNA) biogenesis
mRNA Splicing
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase II Transcription
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Clearance
HIV Infection
Formation of the Early Elongation Complex
RNA Pol II CTD phosphorylation and interaction with CE
RNA Polymerase II Pre-transcription Events
HIV Transcription Initiation
HIV Life Cycle
RNA Pol II CTD phosphorylation and interaction with CE
Transcriptional regulation of pluripotent stem cells
RNA Polymerase II HIV Promoter Escape
HIV Transcription Elongation
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Innate Immune System
RNA Polymerase III Transcription Initiation
Transcriptional regulation by small RNAs
Processing of Capped Intron-Containing Pre-mRNA
mRNA Capping
RNA Polymerase I Transcription
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Cytosolic sensors of pathogen-associated DNA
Epigenetic regulation of gene expression
Negative epigenetic regulation of rRNA expression
Transcription-coupled NER (TC-NER)
Formation of HIV elongation complex in the absence of HIV Tat
Pausing and recovery of HIV elongation
Formation of the HIV-1 Early Elongation Complex
Viral Messenger RNA Synthesis
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Breast cancer (
23535729
)
Breast size (
22747683
)
Esophageal cancer (squamous cell) (
22960999
)
Esophageal cancer and gastric cancer (
20729852
)
Vertical cup-disc ratio (
20548946
)
Protein-Protein Interactions
47 interactors:
AATF
APP
ARHGAP1
ASF1A
ATM
ATR
BRCA1
BRCA2
CDC25A
CDC25C
DAPK3
DBF4
E2F1
ELAVL1
ERCC6
FOXM1
KPNA2
LATS2
MDC1
MDM2
MDM4
MRC1
MSH2
MUS81
NBN
NR4A1
PLK1
PLK3
POLR2L
PPP2CA
PPP2R2A
PPP2R2B
PPP2R5A
PPP2R5B
PPP2R5C
PPP2R5D
PPP2R5E
PRKDC
RAD9A
RCHY1
REV3L
RNF8
SRPK1
STRAP
TP53
TSSK1B
VHL
23 interactors:
BANP
CCDC85B
CHEK2
COIL
EXOSC5
L3MBTL3
NFKBIB
NOV
PHC2
POLR2A
POLR2B
POLR2C
POLR2D
POLR2E
POLR2G
POLR2H
REL
RPAP1
SNX7
SPAG5
THAP1
TP53BP2
ZBTB14
Entrez ID
11200
5441
HPRD ID
05084
01155
Ensembl ID
ENSG00000183765
ENSG00000177700
Uniprot IDs
O96017
P62875
PDB IDs
1GXC
2CN5
2CN8
2W0J
2W7X
2WTC
2WTD
2WTI
2WTJ
2XBJ
2XK9
2XM8
2XM9
2YCF
2YCQ
2YCR
2YCS
2YIQ
2YIR
2YIT
3I6U
3I6W
3VA4
4A9R
4A9S
4A9T
4A9U
4BDA
4BDB
4BDC
4BDD
4BDE
4BDF
4BDG
4BDH
4BDI
4BDJ
4BDK
Enriched GO Terms of Interacting Partners
?
Cellular Response To DNA Damage Stimulus
Cell Cycle Process
Cellular Response To Stress
Cell Cycle
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
DNA Damage Checkpoint
Regulation Of Mitotic Cell Cycle
Cellular Response To Stimulus
Mitotic Cell Cycle
DNA Metabolic Process
Cell Cycle Checkpoint
Response To Stress
Signal Transduction By P53 Class Mediator
DNA Repair
Regulation Of Cell Cycle Process
Signal Transduction In Response To DNA Damage
Regulation Of Metabolic Process
Response To Stimulus
Mitotic Cell Cycle Checkpoint
DNA Damage Response, Signal Transduction By P53 Class Mediator
Response To Radiation
Negative Regulation Of Cell Cycle
Apoptotic Process
Response To Ionizing Radiation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Programmed Cell Death
Mitotic DNA Damage Checkpoint
Regulation Of Protein Metabolic Process
Double-strand Break Repair
Mitotic DNA Integrity Checkpoint
Cell Death
Death
Negative Regulation Of Mitotic Cell Cycle
Negative Regulation Of Cellular Metabolic Process
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Cellular Protein Metabolic Process
Intracellular Signal Transduction
Response To Abiotic Stimulus
Signal Transduction
DNA Recombination
Positive Regulation Of Metabolic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Catalytic Activity
Signaling
Nucleobase-containing Compound Metabolic Process
Cell Communication
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
7-methylguanosine MRNA Capping
PiRNA Metabolic Process
7-methylguanosine RNA Capping
Transcription-coupled Nucleotide-excision Repair
Positive Regulation Of Viral Transcription
Transcription Elongation From RNA Polymerase II Promoter
Somatic Stem Cell Maintenance
Regulation Of Viral Transcription
Positive Regulation Of Viral Process
DNA-templated Transcription, Elongation
Nucleotide-excision Repair
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Stem Cell Maintenance
Regulation Of Viral Process
Gene Expression
Transcription Initiation From RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
Stem Cell Development
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
NcRNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Stem Cell Differentiation
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
MRNA Metabolic Process
RNA Splicing
Cellular Nitrogen Compound Metabolic Process
DNA Repair
Transcription From RNA Polymerase II Promoter
MRNA Processing
Nitrogen Compound Metabolic Process
Biosynthetic Process
Negative Regulation Of Cell Differentiation
DNA Metabolic Process
Regulation Of Gene Expression
Regulation Of RNA Biosynthetic Process
Viral Process
Cellular Response To DNA Damage Stimulus
Regulation Of RNA Metabolic Process
RNA Processing
Regulation Of Nitrogen Compound Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Gene Expression
Positive Regulation Of Cellular Biosynthetic Process
Cell Development
Tagcloud
?
alleles
atm
brca1
brca2
brip1
cdh1
confer
contributing
contributive
fashion
hereditary
influences
lifetime
offers
otherwise
palb2
penetrance
penetrant
personal
polygenic
predisposing
predisposition
quite
snp
stk11
suggestive
suspicion
unlikely
venue
Tagcloud (Difference)
?
alleles
atm
brca1
brca2
brip1
cdh1
confer
contributing
contributive
fashion
hereditary
influences
lifetime
offers
otherwise
palb2
penetrance
penetrant
personal
polygenic
predisposing
predisposition
quite
snp
stk11
suggestive
suspicion
unlikely
venue
Tagcloud (Intersection)
?