CHEK2 and TSSK1B

Number of citations of the paper that reports this interaction (PMID 12556502)
28

Data Source:
HPRD (in vivo)

		CHEK2	TSSK1B
Gene Name		checkpoint kinase 2	testis-specific serine kinase 1B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus PML Body	Acrosomal Vesicle Motile Cilium
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding
	Biological Process	DNA Damage Checkpoint G2/M Transition Of Mitotic Cell Cycle Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated Protein Phosphorylation Cellular Response To DNA Damage Stimulus DNA Damage Induced Protein Phosphorylation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Regulation Of Protein Catabolic Process Signal Transduction In Response To DNA Damage Cellular Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Protein Autophosphorylation Protein Stabilization Cell Division Signal Transduction Involved In Intra-S DNA Damage Checkpoint Mitotic Spindle Assembly Replicative Senescence	Protein Phosphorylation Multicellular Organismal Development Spermatid Development
Pathways
Drugs
Diseases
GWAS		Breast cancer ( 23535729) Breast size ( 22747683) Esophageal cancer (squamous cell) ( 22960999) Esophageal cancer and gastric cancer ( 20729852) Vertical cup-disc ratio ( 20548946)
Protein-Protein Interactions		47 interactors: AATF APP ARHGAP1 ASF1A ATM ATR BRCA1 BRCA2 CDC25A CDC25C DAPK3 DBF4 E2F1 ELAVL1 ERCC6 FOXM1 KPNA2 LATS2 MDC1 MDM2 MDM4 MRC1 MSH2 MUS81 NBN NR4A1 PLK1 PLK3 POLR2L PPP2CA PPP2R2A PPP2R2B PPP2R5A PPP2R5B PPP2R5C PPP2R5D PPP2R5E PRKDC RAD9A RCHY1 REV3L RNF8 SRPK1 STRAP TP53 TSSK1B VHL	4 interactors: CHEK2 EFS TGFBR1 TGFBR2
Entrez ID		11200	83942
HPRD ID		05084	11610
Ensembl ID		ENSG00000183765	ENSG00000212122
Uniprot IDs		O96017	A0ZT98 Q9BXA7
PDB IDs		1GXC 2CN5 2CN8 2W0J 2W7X 2WTC 2WTD 2WTI 2WTJ 2XBJ 2XK9 2XM8 2XM9 2YCF 2YCQ 2YCR 2YCS 2YIQ 2YIR 2YIT 3I6U 3I6W 3VA4 4A9R 4A9S 4A9T 4A9U 4BDA 4BDB 4BDC 4BDD 4BDE 4BDF 4BDG 4BDH 4BDI 4BDJ 4BDK
Enriched GO Terms of Interacting Partners?		Cellular Response To DNA Damage Stimulus Cell Cycle Process Cellular Response To Stress Cell Cycle Regulation Of Cell Cycle Mitotic Cell Cycle Process DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Cellular Response To Stimulus Mitotic Cell Cycle DNA Metabolic Process Cell Cycle Checkpoint Response To Stress Signal Transduction By P53 Class Mediator DNA Repair Regulation Of Cell Cycle Process Signal Transduction In Response To DNA Damage Regulation Of Metabolic Process Response To Stimulus Mitotic Cell Cycle Checkpoint DNA Damage Response, Signal Transduction By P53 Class Mediator Response To Radiation Negative Regulation Of Cell Cycle Apoptotic Process Response To Ionizing Radiation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Programmed Cell Death Mitotic DNA Damage Checkpoint Regulation Of Protein Metabolic Process Double-strand Break Repair Mitotic DNA Integrity Checkpoint Cell Death Death Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Intracellular Signal Transduction Response To Abiotic Stimulus Signal Transduction DNA Recombination Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Signaling Nucleobase-containing Compound Metabolic Process Cell Communication Double-strand Break Repair Via Homologous Recombination Recombinational Repair	Pathway-restricted SMAD Protein Phosphorylation Response To Cholesterol Peptidyl-threonine Phosphorylation Intracellular Signal Transduction Embryonic Cranial Skeleton Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Lens Development In Camera-type Eye Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Palate Development Negative Regulation Of Cellular Response To Growth Factor Stimulus Peptidyl-serine Phosphorylation Embryonic Skeletal System Morphogenesis Signal Transduction Involved In Intra-S DNA Damage Checkpoint Positive Regulation Of Tolerance Induction To Self Antigen Transforming Growth Factor Beta Receptor Signaling Pathway Apoptotic Process Embryonic Skeletal System Development Programmed Cell Death Positive Regulation Of B Cell Tolerance Induction Cell Death Death Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Cellular Response To Growth Factor Stimulus Response To Transforming Growth Factor Beta Bronchus Morphogenesis Positive Regulation Of Growth Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Lens Fiber Cell Apoptotic Process Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Growth Plate Cartilage Chondrocyte Development Activation Of Protein Kinase Activity Skeletal System Morphogenesis Signal Transduction By Phosphorylation Chondrocyte Hypertrophy Positive Regulation Of Skeletal Muscle Tissue Regeneration Growth Plate Cartilage Chondrocyte Differentiation Common-partner SMAD Protein Phosphorylation Positive Regulation Of NK T Cell Differentiation Embryonic Organ Morphogenesis Aging Angiogenesis Positive Regulation Of Cellular Component Movement Parathyroid Gland Development Camera-type Eye Development Bronchus Development Trachea Formation Regulation Of Nuclear Cell Cycle DNA Replication Eye Development
Tagcloud ?		alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Difference) ?		alleles atm brca1 brca2 brip1 cdh1 confer contributing contributive fashion hereditary influences lifetime offers otherwise palb2 penetrance penetrant personal polygenic predisposing predisposition quite snp stk11 suggestive suspicion unlikely venue
Tagcloud (Intersection) ?