PIN1 and DDB1

Number of citations of the paper that reports this interaction (PubMedID 16055720)
76

Data Source:
BioGRID (pull down)

		PIN1	DDB1
Description		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	damage specific DNA binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck Midbody Ciliary Basal Body Glutamatergic Synapse Postsynaptic Cytosol	Chromosome, Telomeric Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Protein-containing Complex Site Of Double-strand Break Extracellular Exosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Cytoskeletal Motor Activity Protein Binding Beta-catenin Binding Isomerase Activity Cis-trans Isomerase Activity Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Tau Protein Binding Phosphoserine Residue Binding Phosphothreonine Residue Binding Phosphoprotein Binding Ubiquitin Ligase Activator Activity	Nucleic Acid Binding DNA Binding Damaged DNA Binding Protein Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding WD40-repeat Domain Binding Cullin Family Protein Binding Ubiquitin Ligase Complex Scaffold Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Response To Hypoxia Positive Regulation Of Protein Phosphorylation Protein Targeting To Mitochondrion Regulation Of Mitotic Nuclear Division Rho Protein Signal Transduction Regulation Of Gene Expression Neuron Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Regulation Of Cytokinesis Negative Regulation Of Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Microtubule Polymerization Synapse Organization Protein Stabilization Negative Regulation Of SMAD Protein Signal Transduction Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Localization To Nucleus Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Cell Motility	DNA Repair Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Spindle Assembly Involved In Female Meiosis Proteasomal Protein Catabolic Process Wnt Signaling Pathway Protein Ubiquitination Viral Release From Host Cell Cellular Response To UV Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Epigenetic Programming In The Zygotic Pronuclei Positive Regulation Of Viral Genome Replication Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Positive Regulation By Virus Of Viral Protein Levels In Host Cell Rhythmic Process Negative Regulation Of Developmental Process Biological Process Involved In Interaction With Symbiont Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Type I Interferon-mediated Signaling Pathway UV-damage Excision Repair Base-excision Repair, AP Site Formation Via Deaminated Base Removal Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Reproductive Process
Pathways		ISG15 antiviral mechanism RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation PI5P Regulates TP53 Acetylation Negative regulators of DDX58/IFIH1 signaling	Recognition of DNA damage by PCNA-containing replication complex DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neddylation
Drugs		Beta-(2-Naphthyl)-Alanine 3,6,9,12,15,18-HEXAOXAICOSANE
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Sleep duration ( 25469926)
Interacting Genes		272 interacting genes: ABI2 ADAMTSL4 ADARB1 AJUBA AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ARID5A ATCAY ATN1 ATP5F1B ATP5MJ BAG6 BARD1 BCL11A BCL2 BCL6 BCLAF1 BRCA1 BRD8 BTG2 C3orf36 CAPRIN1 CARHSP1 CASP6 CBFA2T3 CBS CBY2 CCDC184 CCDC33 CCDC6 CCDC88B CCDC90B CCNB1 CCNE1 CCNK CDC25A CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CEBPA CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPEB1 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DRC12 DYNC1I1 E2F4 EFS EFTUD2 EIF3G EP300 EYA2 FAAP20 FADD FASLG FHL5 FOS FOSL1 FOXI1 FOXN1 FOXO4 FOXP2 FRS2 FUCA2 G3BP1 G3BP2 GGA2 GMEB2 GOLGA2 GOLGA6L9 GPAA1 GPHN GPR152 GRSF1 HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ HOXA1 IKZF1 IKZF3 INCENP INO80E JAKMIP2 JUN KCTD7 KIF20B KIF5A KIFC3 KLHL20 KMT2B KRT31 KRT34 KRT37 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LCN2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX1 MEOX2 MLLT6 MOCS1 MTFR1 MTUS2 MYF5 MYT1 NAB2 NCKIPSD NCOA3 NCOR2 NEK2 NEK6 NELFA NEUROD4 NFATC2 NHERF1 NONO NR4A3 NUP35 NUP62 PABPC1 PAX6 PBX1 PDLIM7 PKIB PKM PKMYT1 PLAGL2 PLEKHG2 PLK1 PML PNMA1 POLR2A PPP1R2 PRPF8 PRRC1 PTOV1 PTPN1 QARS1 RAB4A RAF1 RAI1 RARA RBBP8 RBBP8NL RBPMS RELA REPS1 RNF208 RNPS1 RPL4 RPS6KB1 RUNX2 SCAI SCYL1 SELENOV SEPTIN9 SFPQ SGK1 SHKBP1 SMAD3 SNCAIP SNRNP200 SOCS3 SREK1 SRRM1 SRRM2 SRSF11 SSBP2 SSBP3 SSBP4 SSC5D STIL STK3 SUPT5H TAB3 TBC1D4 TCF12 TCF4 TFG TFPT THAP7 THRAP3 TLE3 TNS2 TOP2A TOX3 TP53 TP63 TP73 TRAF1 TRAF2 TRIM27 TRIM59 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN2 UBQLN4 UBXN2B UNC119 VIRMA WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB2 ZBTB22 ZBTB42 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446 ZNF449 ZNF526 ZNF768 ZNF783	54 interacting genes: ABL1 ANXA1 BCAS3 BRAP BRWD3 CCNK CDK12 CNOT2 COPS5 CUL4A CUL4B DCAF11 DCAF8 DDB2 DET1 DNMT3A DNMT3B DTL EME1 ERCC8 H1-2 H3C1 HOXD3 IKZF1 IP6K1 LMO4 MEF2A MTA2 MUS81 PIN1 POLH PPDPF PTEN RASSF1 RBBP4 RBBP7 RNF26 SALL2 SHANK3 SIN3A SKP2 SNAI1 STAT1 SUPT3H TBL1X TBL1XR1 TP73 USP40 VAMP3 WDTC1 WIPI2 XPA ZEB2 ZNF277
Entrez ID		5300	1642
HPRD ID		03031	10952
Ensembl ID		ENSG00000127445	ENSG00000167986
Uniprot IDs		Q13526	Q16531
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M8I 2M8J 2M9E 2M9F 2M9I 2M9J 2N1O 2Q5A 2RUC 2RUD 2RUQ 2RUR 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB 3WH0 4GWT 4GWV 4QIB 4TNS 4TYO 4U84 4U85 4U86 5B3W 5B3X 5B3Y 5B3Z 5BMY 5GPH 5UY9 5VTI 5VTJ 5VTK 6DUN 6O33 6O34 6SVC 6SVE 6SVH 6VAJ 7AOG 7AXN 7AYF 7AZ1 7AZ2 7BDP 7BDT 7BDY 7BFW 7BG3 7BGQ 7BGR 7BGV 7BGW 7EFJ 7EFX 7EKV 7F0M 7NIF 7NIG 7NJ6 7NJ8 7NJA 7NRK 7NRL 7OQ9 7OQA 7SA5 7SUQ 7SUR 8C2G 8C3C 8SG2 8VJD 8VJE 8VJF 8VJG 9INR 9IT1	2B5L 2B5M 2B5N 2HYE 3E0C 3EI1 3EI2 3EI3 3EI4 3I7H 3I7K 3I7L 3I7N 3I7O 3I7P 3I89 3I8C 3I8E 4A08 4A09 4A0A 4A0B 4A0K 4A0L 4A11 4CI1 4CI2 4CI3 4E54 4E5Z 4TZ4 5FQD 5HXB 5JK7 5V3O 6BN7 6BN8 6BN9 6BNB 6BOY 6DSZ 6FCV 6H0F 6H0G 6PAI 6Q0R 6Q0V 6Q0W 6R8Y 6R8Z 6R90 6R91 6R92 6SJ7 6TD3 6UD7 6UE5 6UML 6XK9 6ZUE 6ZX9 7LPS 7OKQ 7OO3 7OOB 7OOP 7OPC 7OPD 7U8F 7UKN 7V7B 7V7C 7ZN7 7ZNN 8AJM 8AJN 8AJO 8B3D 8B3F 8B3G 8B3I 8BU1 8BU2 8BU3 8BU4 8BU5 8BU6 8BU7 8BU9 8BUA 8BUB 8BUC 8BUD 8BUE 8BUF 8BUG 8BUH 8BUI 8BUJ 8BUK 8BUL 8BUM 8BUN 8BUO 8BUP 8BUQ 8BUR 8BUS 8BUT 8CVP 8D7U 8D7V 8D7W 8D7X 8D7Y 8D7Z 8D80 8D81 8DEY 8G46 8G66 8OIZ 8OJH 8OV6 8QH5 8ROX 8ROY 8T9A 8TL6 8TNP 8TNQ 8TNR 8TZX 8U15 8U16 8U17 8UH6 8WQR 9BBE 9BBG 9BBH 9BBI 9BZ0 9DHD 9DJT 9DJX 9DQD 9EJQ 9ER2 9FD2 9FJX 9FMR
Enriched GO Terms of Interacting Partners?		Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Nucleoplasm Identical Protein Binding Protein Binding Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Negative Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process DNA Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cytosol Positive Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Apoptotic Signaling Pathway Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Transcription Regulator Complex Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Death Apoptotic Process RNA Metabolic Process Programmed Cell Death Promoter-specific Chromatin Binding MRNA Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Speck	Cul4-RING E3 Ubiquitin Ligase Complex Nucleoplasm Nucleus Regulation Of Transcription By RNA Polymerase II Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Complex DNA Metabolic Process Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Stress Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process DNA Repair DNA Damage Response Positive Regulation Of Biosynthetic Process Regulation Of Cell Cycle DNA Binding Response To Stress Protein Modification By Small Protein Conjugation Post-translational Protein Modification Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Protein Ubiquitination Regulation Of Mitotic Cell Cycle Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To UV Cul4B-RING E3 Ubiquitin Ligase Complex Regulation Of Cell Fate Specification Negative Regulation Of RNA Metabolic Process Histone Binding Protein Modification Process Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process
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