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PIN1 and UBQLN4
Number of citations of the paper that reports this interaction (PMID
16713569
)
214
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PIN1
UBQLN4
Gene Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1
ubiquilin 4
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Midbody
Nucleus
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Nuclear Proteasome Complex
Cytosolic Proteasome Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Peptidyl-prolyl Cis-trans Isomerase Activity
Protein Binding
Mitogen-activated Protein Kinase Kinase Binding
GTPase Activating Protein Binding
Phosphoserine Binding
Phosphothreonine Binding
Protein Binding
Polyubiquitin Binding
Identical Protein Binding
Biological Process
Protein Peptidyl-prolyl Isomerization
Positive Regulation Of Protein Phosphorylation
Cell Cycle
Regulation Of Mitotic Nuclear Division
Cytokine-mediated Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Rho GTPase Activity
Regulation Of Cytokinesis
Negative Regulation Of Type I Interferon Production
Innate Immune Response
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Cell Motility
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
Cytokine Signaling in Immune system
Antiviral mechanism by IFN-stimulated genes
Innate Immune System
Drugs
Diseases
GWAS
Inflammatory bowel disease (
23128233
)
Protein-Protein Interactions
184 interactors:
ABI2
ADAMTSL4
ADARB1
AMOT
ANKRD40
AP2A1
APLP1
APP
ARHGEF15
ATP5B
BAG6
BCL2
BCL6
BCLAF1
CAPRIN1
CARHSP1
CASP6
CBS
CCDC184
CCDC33
CCDC90B
CCNB1
CCNE1
CCNK
CDC25C
CDC27
CDK1
CDK11A
CDK11B
CDK12
CDK2
CDK9
CDKN1B
CENPB
CEP55
CEP76
CHAMP1
CHPF
CNKSR1
COL11A2
CPNE6
CSAD
CSNK2A1
CSNK2A2
CSNK2B
CTNNB1
DAB1
DAB2
DDAH2
DDB1
DDX17
DDX24
DDX3X
DDX5
DEAF1
DHX15
DMPK
DYNC1I1
EFTUD2
EIF3G
EP300
ETV6
FASLG
FOXO4
FOXP2
G3BP1
G3BP2
GGA2
GOLGA2
GPAA1
GPHN
HADHA
HEXIM2
HNRNPC
HNRNPH1
HNRNPK
HNRNPU
HOMEZ
IKZF1
IKZF3
JAKMIP2
JUN
KIAA1429
KIF20B
KIF5A
KLHL20
KMT2B
KRT31
KRT38
KRT40
KRTAP10-1
KRTAP10-3
KRTAP10-7
KRTAP10-9
KRTAP4-2
LEPR
LRIF1
MAP1S
MAP3K11
MAPT
MCL1
MDFI
MED1
MEOX2
MOCS1
MTFR1
MTUS2
MYT1
NAB2
NCOA3
NEK6
NFATC2
NONO
NUP62
PABPC1
PKIB
PKM
PKMYT1
PLK1
PML
PNMA1
POLR2A
PRPF8
PRRC1
PTOV1
PTPN1
QARS
RAB4A
RAF1
RAI1
RARA
RBBP8
RBPMS
RELA
REPS1
RNPS1
RPL4
RPS6KB1
SFPQ
SHKBP1
SMAD3
SNRNP200
SOCS3
SPERT
SREK1
SRRM1
SRRM2
SRSF11
SSBP3
STIL
SUPT5H
TAB3
TBC1D4
TCF4
TFG
THAP7
THRAP3
TLE3
TNIP1
TOP2A
TP53
TP73
TRAF1
TRAF2
TRIP6
TRMT2A
TSC2
TSC22D4
TUT1
U2AF2
UBB
UBQLN4
UNC119
WEE1
WIZ
WRNIP1
XRCC6
ZBTB14
ZBTB22
ZBTB7B
ZBTB9
ZCCHC10
ZMIZ2
ZNF446
157 interactors:
ADAM33
ADPGK
AGR2
ANKRD13D
AREG
ARL4C
ATPIF1
ATXN1
BAG6
BPIFA1
C11orf49
C1orf94
C1QTNF1
CACNA1G
CCDC107
CCDC134
CCDC136
CCDC14
CCDC33
CCL21
CD99
CDSN
CEND1
COL8A1
COPB1
CPSF6
CRIPT
CSTF2
CSTF2T
CTSB
CYB5R1
DAZAP2
DKK3
DMPK
DNAJB11
DTX2
EAPP
EDN1
EEF1A1
EFEMP2
ELF5
EPDR1
ERP27
ERP29
FA2H
FGFBP1
FKBP2
FKBP7
FZD7
GABRD
GDI1
GKAP1
GPX7
HAVCR1
HGS
HK2
HSPA13
HSPA5
IGFBP6
IGHM
IGLC1
IMMT
IMPDH2
ITPRIPL1
KLHL26
KLHL42
LAT2
MDK
MDM2
MIEF2
MIF4GD
MLLT6
MOAP1
MYDGF
NAE1
NME3
NOMO1
NOMO3
NOTCH2NL
NPHP1
NPPA
NXF1
OAT
ORC5
PBXIP1
PCDH17
PCDH8
PDIA5
PDLIM7
PELI2
PICK1
PIN1
PIP4K2B
PLA2G16
PMEPA1
PNMA1
PPIB
PPIC
PRL
PRPF40A
PSMD4
PTN
PTPRN
PTPRN2
QSOX1
RAD23A
RAI2
RBM10
RIC8A
RNF11
RNPS1
ROBO2
RPN1
RSRC2
RUNX1T1
RXRA
SCAF1
SCG2
SCG5
SCMH1
SEMG1
SERPINE1
SERPINH1
SERPINI2
SMAD3
SMAD9
SMARCB1
SPAG8
SPINT1
SPP1
SRGN
SRSF2
STAM2
STMN1
SUPT20H
TFF1
TGFB1I1
TNFRSF14
TNRC6B
TRAF2
TRIB2
TRIM32
UBQLN1
UBQLN2
UBR7
UNC119
UROS
USMG5
VIP
WAC
YWHAQ
ZBTB22
ZDHHC3
ZFPM2
ZG16
ZG16B
ZNF205
Entrez ID
5300
56893
HPRD ID
03031
05670
Ensembl ID
ENSG00000127445
ENSG00000160803
Uniprot IDs
Q13526
B4DZF6
Q9NRR5
PDB IDs
1F8A
1I6C
1I8G
1I8H
1NMV
1NMW
1PIN
1ZCN
2F21
2ITK
2KBU
2KCF
2LB3
2M9E
2M9F
2M9I
2M9J
2Q5A
2XP3
2XP4
2XP5
2XP6
2XP7
2XP8
2XP9
2XPA
2XPB
2ZQS
2ZQT
2ZQU
2ZQV
2ZR4
2ZR5
2ZR6
3I6C
3IK8
3IKD
3IKG
3JYJ
3KAB
3KAC
3KAD
3KAF
3KAG
3KAH
3KAI
3KCE
3NTP
3ODK
3OOB
3TC5
3TCZ
3TDB
Enriched GO Terms of Interacting Partners
?
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Regulation Of Metabolic Process
Negative Regulation Of Cellular Metabolic Process
Regulation Of Cell Cycle
Regulation Of Gene Expression
Nitrogen Compound Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Positive Regulation Of Cellular Metabolic Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Mitotic Cell Cycle
RNA Processing
Mitotic Cell Cycle Process
Regulation Of Mitotic Cell Cycle
Cell Death
Death
Negative Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
MRNA Processing
Cell Cycle Process
Regulation Of Nucleic Acid-templated Transcription
Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Cell Cycle Process
Negative Regulation Of Biosynthetic Process
Cell Cycle
Positive Regulation Of Cellular Biosynthetic Process
Positive Regulation Of Gene Expression
Programmed Cell Death
Regulation Of Transcription From RNA Polymerase II Promoter
Apoptotic Process
MRNA Metabolic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Protein Phosphorylation
Negative Regulation Of Transcription, DNA-templated
Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Phosphorylation
Regulation Of Cellular Process
Response To Stress
Positive Regulation Of Cellular Metabolic Process
Response To Stimulus
Signaling
Signal Transduction
Cell Communication
Regulation Of Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Cellular Response To Stimulus
Multicellular Organismal Development
Positive Regulation Of Metabolic Process
Regulation Of Cell Death
Regulation Of Apoptotic Process
Regulation Of Cell Proliferation
Negative Regulation Of Cellular Metabolic Process
Positive Regulation Of Transport
Organ Development
Positive Regulation Of Mitochondrion Organization
Regulation Of Cellular Localization
Regulation Of Proteolysis
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Developmental Process
Response To Organic Substance
Tissue Development
Regulation Of Metabolic Process
Positive Regulation Of Gene Expression
Anatomical Structure Development
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Signal Transduction
Regulation Of Cellular Response To Growth Factor Stimulus
Regulation Of Behavior
Regulation Of Phosphorus Metabolic Process
System Development
Protein Peptidyl-prolyl Isomerization
Regulation Of Signaling
Negative Regulation Of Cell Proliferation
Regulation Of Body Fluid Levels
Regulation Of Chemotaxis
Cell Surface Receptor Signaling Pathway
Regulation Of Phosphorylation
Cellular Localization
Defense Response
Regulation Of Mitochondrion Organization
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Cellular Component Organization
Tagcloud
?
13c
15n
1h
1hn
affinities
aliphatic
assignment
backbone
betap2
complexed
detects
developmentally
enac
isomerase
nedd4
owing
peptidyl
ppxy
proline
prolyl
py
resonances
rnedd4
sequential
shifts
virtually
ww
yap65
yes
Tagcloud (Difference)
?
13c
15n
1h
1hn
affinities
aliphatic
assignment
backbone
betap2
complexed
detects
developmentally
enac
isomerase
nedd4
owing
peptidyl
ppxy
proline
prolyl
py
resonances
rnedd4
sequential
shifts
virtually
ww
yap65
yes
Tagcloud (Intersection)
?