PIN1 and SUPT5H

Number of citations of the paper that reports this interaction (PMID 11575923)
15

Data Source:
HPRD (in vitro)

		PIN1	SUPT5H
Gene Name		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	suppressor of Ty 5 homolog (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Midbody	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Phosphoserine Binding Phosphothreonine Binding	Chromatin Binding Protein Binding Enzyme Binding Poly(A) RNA Binding Protein Heterodimerization Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Motility	Negative Regulation Of Transcription From RNA Polymerase II Promoter Chromatin Remodeling DNA-templated Transcription, Elongation Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Cell Cycle Response To Organic Substance Gene Expression Viral Process Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat mRNA Capping HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		184 interactors: ABI2 ADAMTSL4 ADARB1 AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ATP5B BAG6 BCL2 BCL6 BCLAF1 CAPRIN1 CARHSP1 CASP6 CBS CCDC184 CCDC33 CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 EFTUD2 EIF3G EP300 ETV6 FASLG FOXO4 FOXP2 G3BP1 G3BP2 GGA2 GOLGA2 GPAA1 GPHN HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ IKZF1 IKZF3 JAKMIP2 JUN KIAA1429 KIF20B KIF5A KLHL20 KMT2B KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX2 MOCS1 MTFR1 MTUS2 MYT1 NAB2 NCOA3 NEK6 NFATC2 NONO NUP62 PABPC1 PKIB PKM PKMYT1 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS RAB4A RAF1 RAI1 RARA RBBP8 RBPMS RELA REPS1 RNPS1 RPL4 RPS6KB1 SFPQ SHKBP1 SMAD3 SNRNP200 SOCS3 SPERT SREK1 SRRM1 SRRM2 SRSF11 SSBP3 STIL SUPT5H TAB3 TBC1D4 TCF4 TFG THAP7 THRAP3 TLE3 TNIP1 TOP2A TP53 TP73 TRAF1 TRAF2 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN4 UNC119 WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB22 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446	37 interactors: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CSNK2A1 DBN1 DCAF6 GTF3C1 H2AFX HTATSF1 IK IKBKG LMAN2 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUPT4H1 TERF1 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		5300	6829
HPRD ID		03031	03655
Ensembl ID		ENSG00000127445	ENSG00000196235
Uniprot IDs		Q13526	O00267
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M9E 2M9F 2M9I 2M9J 2Q5A 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB	2DO3 2E6Z 2E70 3H7H 4L1U
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Processing Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Death Death Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated MRNA Processing Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation	Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Transcription, DNA-templated RNA Biosynthetic Process DNA-templated Transcription, Elongation Positive Regulation Of Viral Transcription Viral Process Cellular Macromolecule Biosynthetic Process Regulation Of Viral Transcription Macromolecule Biosynthetic Process Regulation Of Viral Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Biosynthetic Process Regulation Of Gene Expression Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Regulation Of Cellular Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription From RNA Polymerase II Promoter Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Metabolic Process Cell Cycle Cellular Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Negative Regulation Of Gene Expression, Epigenetic Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter
Tagcloud ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Difference) ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	19q13 aa acidic argues consensus differ end family homologue lacks like map maps member near q repeat respond ryanodine seven signals similarity spt5 spt6 terminus unlike w yeast
Tagcloud (Intersection) ?