PIN1 and TCF4

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PIN1	TCF4
Gene Name		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	transcription factor 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Midbody	Nucleus Transcription Factor Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Phosphoserine Binding Phosphothreonine Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding RNA Polymerase Recruiting Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription TFIIB-class Binding Transcription Factor Activity TFIIB-class Transcription Factor Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein C-terminus Binding Protein Heterodimerization Activity E-box Binding
	Biological Process	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Motility	DNA-templated Transcription, Initiation Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein-DNA Complex Assembly
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System	CDO in myogenesis Myogenesis
Drugs
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Diabetic retinopathy ( 21441570) Fuchs's corneal dystrophy ( 20825314) Obesity (early onset extreme) ( 23563609) Schizophrenia ( 21926974 19571808 19571811 22688191 23894747) Sclerosing cholangitis and ulcerative colitis (combined) ( 22821403)
Protein-Protein Interactions		184 interactors: ABI2 ADAMTSL4 ADARB1 AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ATP5B BAG6 BCL2 BCL6 BCLAF1 CAPRIN1 CARHSP1 CASP6 CBS CCDC184 CCDC33 CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 EFTUD2 EIF3G EP300 ETV6 FASLG FOXO4 FOXP2 G3BP1 G3BP2 GGA2 GOLGA2 GPAA1 GPHN HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ IKZF1 IKZF3 JAKMIP2 JUN KIAA1429 KIF20B KIF5A KLHL20 KMT2B KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX2 MOCS1 MTFR1 MTUS2 MYT1 NAB2 NCOA3 NEK6 NFATC2 NONO NUP62 PABPC1 PKIB PKM PKMYT1 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS RAB4A RAF1 RAI1 RARA RBBP8 RBPMS RELA REPS1 RNPS1 RPL4 RPS6KB1 SFPQ SHKBP1 SMAD3 SNRNP200 SOCS3 SPERT SREK1 SRRM1 SRRM2 SRSF11 SSBP3 STIL SUPT5H TAB3 TBC1D4 TCF4 TFG THAP7 THRAP3 TLE3 TNIP1 TOP2A TP53 TP73 TRAF1 TRAF2 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN4 UNC119 WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB22 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446	173 interactors: AES AQP1 AR ARHGEF1 ARMC7 ASCL1 ASCL3 ASCL4 ASPSCR1 ATP6V1B2 BCAS2 BCL2L2 BZRAP1 C19orf66 C1orf109 C9orf171 CABP5 CALM1 CALM2 CALM3 CCDC101 CDC73 CDKN1A CDKN2C CHAF1A CHCHD2 CHIC2 CKS1B CTBP1 CTNNB1 DDX6 DEF6 DGCR6 DMRT3 EFHC1 EIF4E2 EIF4EBP1 EP300 EPB41L3 EPHB6 EXOSC1 FAH FAM124B FAM74A4 FERD3L FLAD1 FLNA FRS3 GEM GLRX3 GNG10 GOLGA8EP GOLGA8F GORASP2 GTF3C5 GUCD1 HAND2 HAT1 HBP1 HIC1 HSPB7 ID1 ID2 ID3 ID4 INS JUN JUP KCTD14 KLC3 KLHL32 LASP1 LENG1 LGALS14 LMO1 LMO4 LNPEP LYL1 MAD2L2 MAGOHB MAPKBP1 MATN3 MEMO1 MEN1 MLLT6 MORN4 MRFAP1L1 MRPL10 MSC MSRB3 MVP MYO5B MYOD1 NCK2 NDOR1 NEK6 NEK8 NEU4 NEUROD1 NEUROG1 NME7 NMUR2 NOL9 NR2C2AP NR4A1 NUDT10 ORC4 OSGIN1 OTUD4 PARK2 PARP1 PATE1 PBLD PIN1 PLEKHN1 POLR1A POLR1C PPIA PPIL1 PPP1R18 PRKAA2 PRKAB2 PSEN1 PSMA1 PSMG2 PTF1A PTGER3 RAB41 RABIF RECK RELA REXO1L6P RNF138 RSPH14 RUNX1T1 SCOC SEC14L4 SIGLEC6 SLC39A13 SLC4A1AP SMCP SMOC1 SPATC1L SPG21 SRSF2 STAMBPL1 STK16 STX11 SUMO1 SZT2 TAL1 TAL2 TAPBPL TCEA2 TCF3 TCL1A TLE1 TMEM213 TRAPPC2L TSSC4 TSSK3 TWIST2 TXNL4B USP4 UTP23 VPS28 XRCC5 XRCC6 ZDHHC24 ZNF124 ZNF205-AS1 ZNF417 ZNF587
Entrez ID		5300	6925
HPRD ID		03031	03780
Ensembl ID		ENSG00000127445	ENSG00000196628
Uniprot IDs		Q13526	B3KVA4 E9PH57 H3BTP3 P15884
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M9E 2M9F 2M9I 2M9J 2Q5A 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB	2KWF
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Processing Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Death Death Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated MRNA Processing Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation	Gene Expression Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Aromatic Compound Metabolic Process Heterocycle Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cell Cycle Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of DNA Binding Negative Regulation Of Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Negative Regulation Of Cellular Protein Metabolic Process Organ Development Regulation Of Metabolic Process Regulation Of Binding System Development Regulation Of Nitrogen Compound Metabolic Process Developmental Process Regulation Of Gene Expression Central Nervous System Development Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Negative Regulation Of DNA Binding Positive Regulation Of Cellular Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Macromolecule Biosynthetic Process Cell Fate Commitment Enzyme Linked Receptor Protein Signaling Pathway
Tagcloud ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Difference) ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	action activities agent beta biejiajian catenin cultured cyclin cytoplasmic d1 downstream expressions fed hepatocellular hepg2 immunofluorescence inhibiting invasiveness lowered luciferase mmp pills qrt sera serve suppress underlying whose wnt
Tagcloud (Intersection) ?