PIN1 and TBC1D4

Number of citations of the paper that reports this interaction (PMID 16055720)
52

Data Source:
BioGRID (pull down)

		PIN1	TBC1D4
Gene Name		peptidylprolyl cis/trans isomerase, NIMA-interacting 1	TBC1 domain family, member 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Midbody	Cytoplasm Cytoplasmic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Mitogen-activated Protein Kinase Kinase Binding GTPase Activating Protein Binding Phosphoserine Binding Phosphothreonine Binding	Rab GTPase Activator Activity
	Biological Process	Protein Peptidyl-prolyl Isomerization Positive Regulation Of Protein Phosphorylation Cell Cycle Regulation Of Mitotic Nuclear Division Cytokine-mediated Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Rho GTPase Activity Regulation Of Cytokinesis Negative Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Motility	Vesicle-mediated Transport Negative Regulation Of Vesicle Fusion Positive Regulation Of Rab GTPase Activity Cellular Response To Insulin Stimulus Membrane Organization
Pathways		RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes Innate Immune System	Translocation of GLUT4 to the plasma membrane
Drugs
Diseases
GWAS			Diabetic retinopathy ( 23562823) Heart failure ( 20445134)
Protein-Protein Interactions		184 interactors: ABI2 ADAMTSL4 ADARB1 AMOT ANKRD40 AP2A1 APLP1 APP ARHGEF15 ATP5B BAG6 BCL2 BCL6 BCLAF1 CAPRIN1 CARHSP1 CASP6 CBS CCDC184 CCDC33 CCDC90B CCNB1 CCNE1 CCNK CDC25C CDC27 CDK1 CDK11A CDK11B CDK12 CDK2 CDK9 CDKN1B CENPB CEP55 CEP76 CHAMP1 CHPF CNKSR1 COL11A2 CPNE6 CSAD CSNK2A1 CSNK2A2 CSNK2B CTNNB1 DAB1 DAB2 DDAH2 DDB1 DDX17 DDX24 DDX3X DDX5 DEAF1 DHX15 DMPK DYNC1I1 EFTUD2 EIF3G EP300 ETV6 FASLG FOXO4 FOXP2 G3BP1 G3BP2 GGA2 GOLGA2 GPAA1 GPHN HADHA HEXIM2 HNRNPC HNRNPH1 HNRNPK HNRNPU HOMEZ IKZF1 IKZF3 JAKMIP2 JUN KIAA1429 KIF20B KIF5A KLHL20 KMT2B KRT31 KRT38 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-2 LEPR LRIF1 MAP1S MAP3K11 MAPT MCL1 MDFI MED1 MEOX2 MOCS1 MTFR1 MTUS2 MYT1 NAB2 NCOA3 NEK6 NFATC2 NONO NUP62 PABPC1 PKIB PKM PKMYT1 PLK1 PML PNMA1 POLR2A PRPF8 PRRC1 PTOV1 PTPN1 QARS RAB4A RAF1 RAI1 RARA RBBP8 RBPMS RELA REPS1 RNPS1 RPL4 RPS6KB1 SFPQ SHKBP1 SMAD3 SNRNP200 SOCS3 SPERT SREK1 SRRM1 SRRM2 SRSF11 SSBP3 STIL SUPT5H TAB3 TBC1D4 TCF4 TFG THAP7 THRAP3 TLE3 TNIP1 TOP2A TP53 TP73 TRAF1 TRAF2 TRIP6 TRMT2A TSC2 TSC22D4 TUT1 U2AF2 UBB UBQLN4 UNC119 WEE1 WIZ WRNIP1 XRCC6 ZBTB14 ZBTB22 ZBTB7B ZBTB9 ZCCHC10 ZMIZ2 ZNF446	14 interactors: AKT1 CDK5RAP2 EP400 FAM208A KIAA1551 NAV1 NFAT5 PIN1 RBM12 TET2 TOPBP1 U2SURP YWHAG ZMIZ1
Entrez ID		5300	9882
HPRD ID		03031	18164
Ensembl ID		ENSG00000127445	ENSG00000136111
Uniprot IDs		Q13526	O60343
PDB IDs		1F8A 1I6C 1I8G 1I8H 1NMV 1NMW 1PIN 1ZCN 2F21 2ITK 2KBU 2KCF 2LB3 2M9E 2M9F 2M9I 2M9J 2Q5A 2XP3 2XP4 2XP5 2XP6 2XP7 2XP8 2XP9 2XPA 2XPB 2ZQS 2ZQT 2ZQU 2ZQV 2ZR4 2ZR5 2ZR6 3I6C 3IK8 3IKD 3IKG 3JYJ 3KAB 3KAC 3KAD 3KAF 3KAG 3KAH 3KAI 3KCE 3NTP 3ODK 3OOB 3TC5 3TCZ 3TDB	3QYB
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cell Cycle Regulation Of Gene Expression Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Mitotic Cell Cycle RNA Processing Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle Cell Death Death Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated MRNA Processing Cell Cycle Process Regulation Of Nucleic Acid-templated Transcription Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Cell Cycle Process Negative Regulation Of Biosynthetic Process Cell Cycle Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Gene Expression Programmed Cell Death Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process MRNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Transcription, DNA-templated Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorylation	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Mitotic Cell Cycle Phase Transition Cell Cycle Cell Cycle Phase Transition Microtubule Bundle Formation Positive Regulation Of Mitochondrion Organization Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process 5-methylcytosine Catabolic Process Glycogen Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Organelle Organization Peptidyl-amino Acid Modification Negative Regulation Of Phosphorylation Regulation Of Mitochondrion Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Vitellogenesis Regulation Of Cell Cycle Process Organelle Organization G2/M Transition Of Mitotic Cell Cycle Cytosine Metabolic Process Regulation Of Neuron Differentiation Liver Morphogenesis Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Negative Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Centriole Replication Hematopoietic Stem Cell Homeostasis Cell Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of MAPK Cascade Response To UV-A Activation-induced Cell Death Of T Cells Oxidative DNA Demethylation Mitotic Cell Cycle Process Intrinsic Apoptotic Signaling Pathway Regulation Of Neurogenesis Myeloid Progenitor Cell Differentiation Cytoplasm Organization Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Apoptotic Signaling Pathway Generation Of Neurons Cellular Response To Insulin Stimulus Mitotic Cell Cycle Negative Regulation Of Protein Kinase Activity
Tagcloud ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Difference) ?		13c 15n 1h 1hn affinities aliphatic assignment backbone betap2 complexed detects developmentally enac isomerase nedd4 owing peptidyl ppxy proline prolyl py resonances rnedd4 sequential shifts virtually ww yap65 yes	amp elucidate evidenced fasting glucose glycogen homeostasis irs1 knock lethality member mnuak1ko motility muscle nuak1 null oxidative phenotypic phosphoproteome physiological preferentially senescence ser soleus suppress thr tolerance tyr understand
Tagcloud (Intersection) ?