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GRN and SNRNP48
Number of citations of the paper that reports this interaction (PubMedID
34133714
)
84
Data Source:
BioGRID
(two hybrid)
GRN
SNRNP48
Description
granulin precursor
small nuclear ribonucleoprotein U11/U12 subunit 48
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Vesicle
Azurophil Granule Lumen
Extracellular Exosome
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Nucleus
Nucleoplasm
Spliceosomal Complex
U12-type Spliceosomal Complex
Cytosol
Molecular Function
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Protein-folding Chaperone Binding
Protein Binding
Zinc Ion Binding
Metal Ion Binding
Biological Process
Trophectodermal Cell Proliferation
Blastocyst Hatching
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Locomotory Exploration Behavior
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
Positive Regulation Of Axon Regeneration
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
Protein Stabilization
Positive Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Retina Development In Camera-type Eye
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Maintenance Of Synapse Structure
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Trophectodermal Cell Proliferation
Lysosomal Protein Catabolic Process
Positive Regulation Of Aspartic-type Peptidase Activity
Regulation Of Lysosome Organization
Positive Regulation Of Lysosome Organization
MRNA Processing
RNA Splicing
Pathways
Neutrophil degranulation
mRNA Splicing - Minor Pathway
Drugs
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Mild age-related type 2 diabetes (
34737425
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
BMI x environmental factors (excluding physical activity) interaction (
33654129
)
BMI x environmental factors (including physical activity) interaction (
33654129
)
Height (
31562340
)
Obesity-related traits (
23251661
)
Interacting Genes
88 interacting genes:
ALG13
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT31
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1B
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
LCE5A
MBD1
MEOX2
NEDD8
NLK
NUFIP2
OTX1
P4HB
PCM1
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SHANK3
SLC13A1
SLPI
SMAD9
SMCP
SNRNP48
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
14 interacting genes:
CDCA7L
ENKD1
EXOSC7
GPX4
GRN
HUNK
LUC7L2
MRPS27
PRPF6
SRSF8
SUPT5H
TFIP11
UBASH3A
UTP14A
Entrez ID
2896
154007
HPRD ID
00733
12858
Ensembl ID
ENSG00000030582
ENSG00000168566
Uniprot IDs
P28799
Q6IEG0
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
8T8R
8T8S
2VY4
2VY5
8R7N
8Y6O
9GBW
9GC0
9GCL
Enriched GO Terms of Interacting Partners
?
Keratinization
Intermediate Filament
Epidermis Development
Keratin Filament
Protein Binding
Tissue Development
P-TEFb Complex
Nuclear Matrix
Identical Protein Binding
RNA Binding
Nuclear Speck
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?