GRN and CDK9

Number of citations of the paper that reports this interaction (PMID 12588988)
23

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRN	CDK9
Gene Name		granulin	cyclin-dependent kinase 9
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Positive Transcription Elongation Factor Complex B Membrane PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding	DNA Binding Chromatin Binding Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding RNA Polymerase II Carboxy-terminal Domain Kinase Activity SnRNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation	DNA Repair Regulation Of DNA Repair Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Cell Proliferation Gene Expression Viral Process Regulation Of Histone Modification Replication Fork Arrest Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription Negative Regulation Of Cell Cycle Arrest Cellular Response To Cytokine Stimulus
Pathways			Loss of Function of TGFBR2 in Cancer Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection SMAD2/3 MH2 Domain Mutants in Cancer Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery TGFBR1 LBD Mutants in Cancer RNA Polymerase II Pre-transcription Events SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer HIV elongation arrest and recovery HIV Life Cycle Generic Transcription Pathway HIV Transcription Elongation TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer Interactions of Tat with host cellular proteins TGFBR1 KD Mutants in Cancer Pausing and recovery of Tat-mediated HIV elongation Loss of Function of TGFBR1 in Cancer Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription of the HIV genome SMAD4 MH2 Domain Mutants in Cancer RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Intracranial volume ( 22504418)
Protein-Protein Interactions		37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1	56 interactors: ACTL6A AFF4 AR BCL10 BRCA1 CASK CCNK CCNT1 CCNT2 CDC34 CDC7 CDK5R1 CDK7 CTD CTDP1 CTDSPL CUL1 DHX30 FBXO25 GRN GTF2F1 HEXIM1 HEXIM2 HIST2H2BE HLTF HSPA1A HTATSF1 IL6ST MBP MDFIC MED21 MYBL2 NBN NFKB1 NR2E3 PIN1 POLR2A RB1 RCHY1 RELA RMND5B RN7SK SERPINH1 SKP1 SKP2 SMAD1 SMAD2 SMAD3 STAT3 STK36 SUPT5H TAF7 TP53 TRAF2 UBE2A ZMYM6
Entrez ID		2896	1025
HPRD ID		00733	16016
Ensembl ID		ENSG00000030582	ENSG00000136807
Uniprot IDs		P28799	P50750
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	1PF6 3BLH 3BLQ 3BLR 3LQ5 3MI9 3MIA 3MY1 3TN8 3TNH 3TNI 4BCF 4BCG 4BCH 4BCI 4BCJ 4EC8 4EC9 4IMY
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated	Positive Regulation Of Cellular Metabolic Process Viral Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Cell Cycle Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Cellular Process Transcription Initiation From RNA Polymerase II Promoter Cellular Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Viral Transcription Regulation Of Phosphorylation Regulation Of Protein Phosphorylation DNA-templated Transcription, Initiation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Phosphorus Metabolic Process Biosynthetic Process Regulation Of Viral Transcription Cell Cycle Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Response To Stimulus Regulation Of Cell Proliferation Negative Regulation Of Gene Expression Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	affects associate bulk ccnk cdk12 cdk13 cdks ctd elongation far flag hct116 heptad implementing numerous paralog partner phosphorylate preferentially processing repeat reveals rna sec seq snorna super tagged tefb
Tagcloud (Intersection) ?