GRN and SLPI

Number of citations of the paper that reports this interaction (PMID 12526812)
114

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		GRN	SLPI
Gene Name		granulin	secretory leukocyte peptidase inhibitor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Extracellular Matrix Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding
	Biological Process	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Protein Binding Negative Regulation Of Viral Genome Replication
Pathways
Drugs
Diseases
GWAS		Intracranial volume ( 22504418)
Protein-Protein Interactions		37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1	10 interactors: CTSB CTSL CTSS ELANE FAM9B GRN KLK3 PLSCR1 PRSS2 SGTA
Entrez ID		2896	6590
HPRD ID		00733	00121
Ensembl ID		ENSG00000030582	ENSG00000124107
Uniprot IDs		P28799	P03973
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated	Extracellular Matrix Disassembly Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Organization Extracellular Structure Organization Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Defense Response Positive Regulation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Immune Response Acute Inflammatory Response Proteolysis Regulation Of Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Immune System Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Immune System Process Response To Stress Immune Response Protein Catabolic Process Regulation Of Immune System Process Regulation Of Inflammatory Response Innate Immune Response Catabolic Process Inflammatory Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response-regulating Signaling Pathway Positive Regulation Of Inflammatory Response Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Factor XII Activation Neutrophil Mediated Killing Of Fungus Basement Membrane Disassembly Macrophage Apoptotic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Hormone Stimulus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Response To Organic Substance Response To Stimulus Positive Regulation Of Fibrinolysis Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Response To Yeast Phosphatidylserine Biosynthetic Process
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	21x 72x a2 a2t annexin attributed correlating embedded entities facilitating formalin heterotetramer hnscc hnsccs hpv inverse lab nonsmokers paraffin protect protects putatively scc separately smokers supports surplus tobacco tonsillar
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	21x 72x a2 a2t annexin attributed correlating embedded entities facilitating formalin heterotetramer hnscc hnsccs hpv inverse lab nonsmokers paraffin protect protects putatively scc separately smokers supports surplus tobacco tonsillar
Tagcloud (Intersection) ?