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GRN and HSPG2
Number of citations of the paper that reports this interaction (PubMedID
12900424
)
0
Data Source:
HPRD
(in vivo)
GRN
HSPG2
Description
granulin precursor
heparan sulfate proteoglycan 2
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Endosome
Late Endosome
Endoplasmic Reticulum
Golgi Apparatus
Trans-Golgi Network
Plasma Membrane
Membrane
Vesicle
Azurophil Granule Lumen
Extracellular Exosome
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Extracellular Region
Basement Membrane
Extracellular Space
Golgi Lumen
Plasma Membrane
Focal Adhesion
Extracellular Matrix
Neuron Projection
Lysosomal Lumen
Extracellular Exosome
Plasma Membrane Protein Complex
Molecular Function
RNA Binding
Cytokine Activity
Protein Binding
Growth Factor Activity
Protein-folding Chaperone Binding
Amyloid-beta Binding
Integrin Binding
Calcium Ion Binding
Protein Binding
Extracellular Matrix Structural Constituent Conferring Compression Resistance
Metal Ion Binding
Low-density Lipoprotein Particle Receptor Binding
Collagen V Binding
Biological Process
Trophectodermal Cell Proliferation
Blastocyst Hatching
Astrocyte Activation Involved In Immune Response
Microglial Cell Activation Involved In Immune Response
Lysosome Organization
Lysosomal Transport
Lysosomal Lumen Acidification
Signal Transduction
Embryo Implantation
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cell Migration
Locomotory Exploration Behavior
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Angiogenesis
Negative Regulation Of Innate Immune Response
Positive Regulation Of Axon Regeneration
Epithelial Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Regulation Of Developmental Process
Protein Stabilization
Positive Regulation Of Cellular Component Organization
Establishment Of Localization In Cell
Retina Development In Camera-type Eye
Negative Regulation Of Respiratory Burst Involved In Inflammatory Response
Maintenance Of Synapse Structure
Positive Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Defense Response To Bacterium
Negative Regulation Of Neutrophil Activation
Positive Regulation Of Protein Folding
Negative Regulation Of Microglial Cell Activation
Positive Regulation Of Trophectodermal Cell Proliferation
Lysosomal Protein Catabolic Process
Positive Regulation Of Aspartic-type Peptidase Activity
Regulation Of Lysosome Organization
Positive Regulation Of Lysosome Organization
Angiogenesis
Response To Hypoxia
Positive Regulation Of Endothelial Cell Proliferation
Lipid Metabolic Process
Receptor-mediated Endocytosis
Inflammatory Response
Negative Regulation Of Cell Adhesion
Smoothened Signaling Pathway
Brain Development
Embryo Implantation
Negative Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Negative Regulation Of Angiogenesis
Cell Differentiation
Animal Organ Regeneration
Negative Regulation Of Neuron Apoptotic Process
Circulatory System Development
Negative Regulation Of Amyloid Fibril Formation
Pathways
Neutrophil degranulation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Glycosaminoglycan-protein linkage region biosynthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Non-integrin membrane-ECM interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Attachment and Entry
Attachment and Entry
Retinoid metabolism and transport
Amyloid fiber formation
Respiratory syncytial virus (RSV) attachment and entry
RSV-host interactions
Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Palifermin
Diseases
Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
Heparan sulfate proteoglycan gene defects, including: Dyssegmental dysplasia, Silverman-Handmaker type; Schwartz-Jampel syndrome; Simpson-Golabi-Behmel syndrome, type 1; Omodysplasia 1; Multiple exostoses
GWAS
Blood protein levels (
30072576
)
Brain morphology (MOSTest) (
32665545
)
Intracranial volume (
22504418
)
Mild age-related type 2 diabetes (
34737425
)
Progranulin levels (
29186428
)
Subcortical brain region volumes (
25607358
)
Atrial fibrillation (
30061737
)
Cerebral microbleeds (lobar) (
32913026
)
Height (
28552196
)
PR interval (
32439900
)
Interacting Genes
88 interacting genes:
ALG13
ARFGAP1
ATN1
ATXN7
C22orf39
C4orf17
CACNA1A
CCDC33
CCNG1
CCNT1
CDK9
CLPP
CRCT1
CRKL
CRY1
CXCL5
CYSRT1
DLK1
DLX2
DMRT3
ECM1
ELANE
FAM131C
FAM76B
FANCL
FRAT1
GFI1B
GLRX3
GNE
HK3
HOXA1
HSPG2
KRT18
KRT31
KRT34
KRTAP1-1
KRTAP1-5
KRTAP10-7
KRTAP10-8
KRTAP11-1
KRTAP12-1
KRTAP13-2
KRTAP15-1
KRTAP26-1
KRTAP5-9
KRTAP6-1
KRTAP6-2
LCE1A
LCE1B
LCE1D
LCE1E
LCE2B
LCE2D
LCE3C
LCE3E
LCE4A
LCE5A
MBD1
MEOX2
NEDD8
NLK
NUFIP2
OTX1
P4HB
PCM1
PIK3R2
PLLP
POT1
POU4F2
PRKAB2
PTPMT1
RAC1
SGTA
SHANK3
SLC13A1
SLPI
SMAD9
SMCP
SNRNP48
SPRY2
TAT
TGM2
TLE5
TOP3B
TSPAN4
UTP23
VASN
YY1
33 interacting genes:
APP
ATF7IP
ATN1
BMP1
CACNA1A
CCN2
COL13A1
ECM1
FBLN1
FBLN2
FBN1
FGF2
FGF7
FGFBP1
FN1
GFI1B
GRN
HSP90AA1
ITGA2
ITGB1
LAMA1
MTDH
NID1
NID2
PDGFA
PDGFB
PRELP
PRPF40A
SPARC
TCAP
TTR
UBC
VWA1
Entrez ID
2896
3339
HPRD ID
00733
00804
Ensembl ID
ENSG00000030582
ENSG00000142798
Uniprot IDs
P28799
P98160
PDB IDs
1G26
2JYE
2JYT
2JYU
2JYV
6NUG
8T8R
8T8S
3SH4
3SH5
Enriched GO Terms of Interacting Partners
?
Keratinization
Intermediate Filament
Epidermis Development
Keratin Filament
Protein Binding
Tissue Development
P-TEFb Complex
Nuclear Matrix
Identical Protein Binding
Extracellular Matrix Structural Constituent
Extracellular Matrix
Extracellular Region
Extracellular Space
Basement Membrane
Heparin Binding
Collagen Binding
Positive Regulation Of Cell Migration
Integrin Binding
Positive Regulation Of Cell Motility
Positive Regulation Of Locomotion
Regulation Of Cell Migration
Cell-matrix Adhesion
Regulation Of Cell Motility
Regulation Of Locomotion
Cell-substrate Adhesion
Extracellular Matrix Organization
Extracellular Structure Organization
Regulation Of Multicellular Organismal Process
Regulation Of Developmental Process
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Platelet Alpha Granule Lumen
Regulation Of Endothelial Cell Proliferation
Chemoattractant Activity
Growth Factor Activity
Peptidase Activator Activity
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of ERK1 And ERK2 Cascade
Endoplasmic Reticulum Lumen
Integrin-mediated Signaling Pathway
Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Angiogenesis
Positive Chemotaxis
Positive Regulation Of Cell Communication
Positive Regulation Of Epithelial Cell Proliferation
Response To Wounding
Positive Regulation Of Endothelial Cell Migration
Cell Adhesion
Regulation Of Anatomical Structure Morphogenesis
Positive Regulation Of Developmental Process
Platelet-derived Growth Factor Complex
Negative Regulation Of Phosphatidylinositol Biosynthetic Process
Positive Regulation Of Signal Transduction
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Cell-substrate Adhesion
Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Epithelial Cell Proliferation
Animal Organ Development
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Tagcloud (Intersection)
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