GRN and TAT

Number of citations of the paper that reports this interaction (PMID 12588988)
23

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GRN	TAT
Gene Name		granulin	tyrosine aminotransferase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Cellular_component Mitochondrion Cytosol
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding	L-tyrosine:2-oxoglutarate Aminotransferase Activity Amino Acid Binding Pyridoxal Phosphate Binding L-phenylalanine:2-oxoglutarate Aminotransferase Activity
	Biological Process	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation	2-oxoglutarate Metabolic Process Glutamate Metabolic Process L-phenylalanine Catabolic Process Tyrosine Catabolic Process Response To Oxidative Stress Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Response To Mercury Ion Response To Glucocorticoid
Pathways			Phenylalanine and tyrosine catabolism Metabolism of amino acids and derivatives
Drugs			Pyridoxal Phosphate L-Phenylalanine L-Tyrosine L-Glutamic Acid
Diseases
GWAS		Intracranial volume ( 22504418)	Metabolite levels ( 22286219 22916037)
Protein-Protein Interactions		37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1	2 interactors: GRN UBE3A
Entrez ID		2896	6898
HPRD ID		00733	11776
Ensembl ID		ENSG00000030582
Uniprot IDs		P28799	P17735
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	3DYD
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated	Sperm Entry Blastocyst Hatching Prostate Gland Growth Single Organism Reproductive Process Reproductive Process Protein K48-linked Ubiquitination Androgen Receptor Signaling Pathway Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Ovarian Follicle Development Prostate Gland Development Intracellular Steroid Hormone Receptor Signaling Pathway Embryo Implantation Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Circadian Rhythm Blastocyst Development Ovulation Cycle Process Organ Growth Female Gonad Development Ovulation Cycle Development Of Primary Female Sexual Characteristics
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	acetyltransferase arrangement associates basic binds cbp chromosomally coactivator conformation creb hat integrated integrity ltr nucleosome performs pivotal promoters reactivation recruiting reinforce relieves remodeling repeat rodent silent transactivation transcriptionally viral
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	acetyltransferase arrangement associates basic binds cbp chromosomally coactivator conformation creb hat integrated integrity ltr nucleosome performs pivotal promoters reactivation recruiting reinforce relieves remodeling repeat rodent silent transactivation transcriptionally viral
Tagcloud (Intersection) ?