GRN and TAT

Number of citations of the paper that reports this interaction (PubMedID 12588988)
71

Data Source:
BioGRID (pull down, affinity chromatography technology)

		GRN	TAT
Description		granulin precursor	tyrosine aminotransferase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse	Cellular_component Cytosol
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding	Catalytic Activity L-tyrosine-2-oxoglutarate Transaminase Activity Protein Binding Transaminase Activity Amino Acid Binding Transferase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization	2-oxoglutarate Metabolic Process Amino Acid Metabolic Process Glutamate Metabolic Process L-phenylalanine Catabolic Process L-tyrosine Catabolic Process Response To Oxidative Stress Aromatic Amino Acid Metabolic Process Aromatic Amino Acid Family Catabolic Process Response To Mercury Ion Response To Glucocorticoid Response To Dexamethasone
Pathways		Neutrophil degranulation	Tyrosine catabolism
Drugs			Pyridoxal phosphate Phenylalanine Tyrosine Glutamic acid
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)	Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	Chronotype ( 30696823) Metabolite levels ( 22286219 22916037) Morning person ( 30696823) Urate levels ( 31578528)
Interacting Genes		88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	3 interacting genes: GLUL GRN UBE3A
Entrez ID		2896	6898
HPRD ID		00733	11776
Ensembl ID		ENSG00000030582	ENSG00000198650
Uniprot IDs		P28799	A0A140VKB7 P17735
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S	3DYD
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding	Intracellular Chemical Homeostasis Intracellular PH Reduction Cellular Homeostasis Regulation Of Cellular PH Regulation Of Intracellular PH Intracellular Ammonium Homeostasis Chemical Homeostasis Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of PH Sperm Entry Positive Regulation Of Golgi Lumen Acidification Glutamine Synthetase Activity Glutamine Biosynthetic Process Positive Regulation Of Trophectodermal Cell Proliferation Regulation Of Endothelial Cell Migration Homeostatic Process Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Protein Folding Regulation Of Golgi Lumen Acidification Cellular Response To Nutrient Levels Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Trophectodermal Cell Proliferation Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Cellular PH Reduction Ammonium Homeostasis Regulation Of Angiogenesis Negative Regulation Of Respiratory Burst Positive Regulation Of Protein Localization To Lysosome Regulation Of Vasculature Development L-glutamate Catabolic Process Catabolic Process Negative Regulation Of Neutrophil Activation Negative Regulation Of Microglial Cell Activation Regulation Of Respiratory Burst Involved In Inflammatory Response Cerebellar Climbing Fiber To Purkinje Cell Synapse Regulation Of Proteolysis Positive Regulation Of Axon Regeneration Intracellular Monoatomic Cation Homeostasis Regulation Of Protein Folding Intracellular Monoatomic Ion Homeostasis Prostate Gland Growth Regulation Of Protein Localization To Nucleolus Regulation Of Neutrophil Activation Positive Regulation Of Peptidase Activity Positive Regulation Of Defense Response To Bacterium Progesterone Receptor Signaling Pathway Response To Nutrient Levels Monoatomic Ion Homeostasis
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