GRN and HK3

Number of citations of the paper that reports this interaction (PMID 11068878)
4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		GRN	HK3
Gene Name		granulin	hexokinase 3 (white cell)
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Mitochondrion Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome	Mitochondrion Cytosol Protein Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Poly(A) RNA Binding	Glucokinase Activity Hexokinase Activity ATP Binding Fructokinase Activity Mannokinase Activity Enzyme Binding Hormone Binding
	Biological Process	Blastocyst Hatching Signal Transduction Embryo Implantation Positive Regulation Of Epithelial Cell Proliferation	Cellular Glucose Homeostasis Carbohydrate Metabolic Process Glycolytic Process Hexose Transport Pathogenesis Glucose Transport Hexose Metabolic Process Small Molecule Metabolic Process Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Transmembrane Transport
Pathways			Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates Glucose transport SLC-mediated transmembrane transport Hexose transport
Drugs
Diseases
GWAS		Intracranial volume ( 22504418)
Protein-Protein Interactions		37 interactors: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 TAT TGM2 TOP3B YY1	9 interactors: ATF4 GRN HPGDS IGFBP4 LEP MITF PPP2CB PTGDS ZBTB17
Entrez ID		2896	3101
HPRD ID		00733	00806
Ensembl ID		ENSG00000030582	ENSG00000160883
Uniprot IDs		P28799	P52790
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV	3HM8
Enriched GO Terms of Interacting Partners?		Response To Organic Substance Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Central Nervous System Development Positive Regulation Of Cellular Biosynthetic Process Regulation Of Cellular Process Regulation Of Metabolic Process Brain Development Regulation Of Kinase Activity Head Development Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Cellular Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Organic Substance Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Pattern Specification Process RNA Biosynthetic Process Regulation Of Phosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Anatomical Structure Morphogenesis Biosynthetic Process Negative Regulation Of Biosynthetic Process Homeostatic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Positive Regulation Of Metabolic Process Embryonic Organ Morphogenesis Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Embryonic Skeletal System Development Response To Light Stimulus Hindbrain Development Regulation Of Protein Metabolic Process Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Phosphorus Metabolic Process Pons Development Cell Surface Receptor Signaling Pathway Response To Stimulus Response To Transforming Growth Factor Beta Positive Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Signal Transduction Cellular Aromatic Compound Metabolic Process Central Nervous System Neuron Differentiation Anatomical Structure Development Positive Regulation Of Transcription, DNA-templated	Cyclooxygenase Pathway Response To Endoplasmic Reticulum Stress Prostaglandin Biosynthetic Process Signal Transduction Prostaglandin Metabolic Process Response To Stimulus Signaling Cell Communication Icosanoid Biosynthetic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Phosphorylation Unsaturated Fatty Acid Biosynthetic Process Positive Regulation Of Nuclease Activity Fatty Acid Metabolic Process Cellular Response To Stimulus Arachidonic Acid Metabolic Process Carboxylic Acid Metabolic Process Cellular Response To L-ascorbic Acid Positive Regulation Of Luteinizing Hormone Secretion Negative Regulation Of Glutamine Transport Endoplasmic Reticulum Unfolded Protein Response Organic Acid Metabolic Process Negative Regulation Of Ion Transport Icosanoid Metabolic Process Cellular Response To Unfolded Protein Regulation Of Glucose Metabolic Process Unsaturated Fatty Acid Metabolic Process ER-nucleus Signaling Pathway Positive Regulation Of Hepatic Stellate Cell Activation Cellular Response To Topologically Incorrect Protein Regulation Of Phosphorylation Long-chain Fatty Acid Metabolic Process Monocarboxylic Acid Metabolic Process Response To Unfolded Protein Negative Regulation Of Vasoconstriction Glycerol Biosynthetic Process Negative Regulation Of Glucagon Secretion Regulation Of Lipoprotein Lipid Oxidation Fatty Acid Biosynthetic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Glucose Metabolic Process Regulation Of Carbohydrate Metabolic Process Regulation Of Phosphorus Metabolic Process Carbohydrate Biosynthetic Process Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of STAT Protein Import Into Nucleus Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm
Tagcloud ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Difference) ?		arose backcrosses bareskin bsk chr clustered corneal den denuded facility granulin hair intersubspecific junctional jup keratin kinds krt1 linkage mapped opacity plakoglobin portion rara recombination resembling rex rim3 spontaneously	5q35 boundary british canx centromeric conspicuously d5s2006 d5s2073 d5s408 dominantly fgfr4 genomewide hampered haplotypes hnrph1 lymphatic lymphedema milroy mim multipoint pcl penetrance positionally recombinants scorable segregated telomeric vicinity wiaf
Tagcloud (Intersection) ?