GRN and CRY1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GRN	CRY1
Description		granulin precursor	cryptochrome circadian regulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse	Nucleus Cytoplasm Mitochondrion
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding	Nucleotide Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Photoreceptor Activity Blue Light Photoreceptor Activity Nuclear Receptor Binding Kinase Binding Protein Kinase Binding Phosphatase Binding Histone Deacetylase Binding E-box Binding FAD Binding DNA-binding Transcription Factor Binding
	Biological Process	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Gluconeogenesis Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Lipid Storage Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Signal Transduction In Response To DNA Damage Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Gluconeogenesis Positive Regulation Of Gluconeogenesis Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of DNA Damage Checkpoint Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		Neutrophil degranulation	Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes The CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Degradation of CRY and PER proteins
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	Morning person ( 30696823) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	25 interacting genes: ARIH1 BHLHE41 BMAL1 CBLB CLOCK CSNK1E DELEC1 GRN KRTAP4-12 LTBP4 MDFI NPAS2 NR1D2 PER1 PER2 PER3 PLSCR1 PPP2R1B PPP2R5D PPP2R5E SNRPD3 TIMELESS TRAF2 USP2 USP7
Entrez ID		2896	1407
HPRD ID		00733	09050
Ensembl ID		ENSG00000030582	ENSG00000008405
Uniprot IDs		P28799	A2I2P0 Q16526
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding	Circadian Rhythm Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process Photoperiodism CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod Entrainment Of Circadian Clock Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Response To Redox State E-box Binding Protein Phosphatase Type 2A Complex Negative Regulation Of RNA Metabolic Process Circadian Behavior Nucleoplasm Rhythmic Behavior Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of Hair Cycle Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Phosphatase Regulator Activity Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Corepressor Binding Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Primary Metabolic Process Response To Light Stimulus Meiotic Sister Chromatid Cohesion Regulation Of RNA Metabolic Process Protein Dimerization Activity Negative Regulation Of Macromolecule Metabolic Process Chromatoid Body Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Membrane Raft Regulation Of Nucleobase-containing Compound Metabolic Process Protein Phosphatase Activator Activity Positive Regulation Of Circadian Rhythm Protein Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Response To Radiation Regulation Of Transcription By RNA Polymerase II Regulation Of Skeletal Muscle Cell Differentiation Transcription Cis-regulatory Region Binding
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