GRN and UTP23

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRN	UTP23
Description		granulin precursor	UTP23 small subunit processome component
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse	Nucleus Nucleolus Small-subunit Processome
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding	RNA Binding MRNA 3'-UTR Binding Protein Binding MRNA 5'-UTR Binding Small Ribosomal Subunit RRNA Binding
	Biological Process	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization	Endonucleolytic Cleavage In 5'-ETS Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Ribosome Biogenesis
Pathways		Neutrophil degranulation
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	31 interacting genes: APP CYSRT1 DDX52 FCF1 GOLGA2 GRN KRT31 KRT34 KRT38 KRT40 KRTAP1-3 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-3 MEOX2 MID2 NBPF19 NFKBID NHP2 NOTCH2NLA PDE9A RRP7A SNHG3 TCF4 TEPSIN TRAF2 TRIB3 TRIM23 TRIM27
Entrez ID		2896	84294
HPRD ID		00733	17499
Ensembl ID		ENSG00000030582	ENSG00000147679
Uniprot IDs		P28799	Q9BRU9
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding	Keratin Filament Intermediate Filament Structural Constituent Of Skin Epidermis Intermediate Filament Organization Astrocyte Activation Involved In Immune Response Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Identical Protein Binding Supramolecular Fiber Organization Structural Molecule Activity Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Astrocyte Activation Regulation Of Autophagy RRNA Processing Regulation Of Viral Transcription
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