GRN and CXCL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GRN	CXCL5
Description		granulin precursor	C-X-C motif chemokine ligand 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding	Cytokine Activity Protein Binding Chemokine Activity Identical Protein Binding CXCR Chemokine Receptor Binding
	Biological Process	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization	Chemotaxis Defense Response Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Lipopolysaccharide
Pathways		Neutrophil degranulation	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	CXCL5 levels ( 25147954) Inflammatory bowel disease ( 23128233) Metabolite levels ( 22916037) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	20 interacting genes: ACKR1 ACTN3 ALPP CCL11 CCL20 CXCL1 CXCL14 CXCL2 CXCL3 CXCR1 CXCR2 EFEMP2 FBLN1 GRN MEOX2 MGAT5B MMP9 NOTCH2NLA VWC2L XCL2
Entrez ID		2896	6374
HPRD ID		00733	08976
Ensembl ID		ENSG00000030582	ENSG00000163735
Uniprot IDs		P28799	P42830 Q6I9S7
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S	2MGS 8XWS 8XX7
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding	Chemokine Activity Cell Chemotaxis Cytokine Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemotaxis Locomotion Antimicrobial Humoral Response Killing Of Cells Of Another Organism Humoral Immune Response Cell Migration Chemokine-mediated Signaling Pathway Extracellular Region Cell Killing Cell Motility Inflammatory Response Extracellular Space Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Granulocyte Chemotaxis C-C Chemokine Binding Immune Response Granulocyte Migration Interleukin-8 Binding Leukocyte Migration Defense Response Elastic Fiber Defense Response To Symbiont Myeloid Leukocyte Migration Immune System Process Defense Response To Other Organism Embryo Implantation Leukocyte Chemotaxis Signal Transduction Positive Regulation Of Cell Migration Neutrophil Chemotaxis C-X-C Chemokine Receptor Activity Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Neutrophil Migration Response To External Biotic Stimulus Regulation Of Cell Migration Cytokine-mediated Signaling Pathway Regulation Of Cell Motility Regulation Of Locomotion Response To Other Organism Dendritic Cell Chemotaxis G Protein-coupled Receptor Signaling Pathway Mononuclear Cell Migration Chemokine Receptor Activity C-C Chemokine Receptor Activity
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