GRN and DLK1

Number of citations of the paper that reports this interaction (PubMedID 11846389)
0

Data Source:
HPRD (two hybrid)

		GRN	DLK1
Description		granulin precursor	delta like non-canonical Notch ligand 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Vesicle Azurophil Granule Lumen Extracellular Exosome Cerebellar Climbing Fiber To Purkinje Cell Synapse	Extracellular Space Cytoplasm Membrane
	Molecular Function	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Protein-folding Chaperone Binding	Calcium Ion Binding Protein Binding
	Biological Process	Trophectodermal Cell Proliferation Blastocyst Hatching Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Embryo Implantation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Locomotory Exploration Behavior Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response Positive Regulation Of Axon Regeneration Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Protein Stabilization Positive Regulation Of Cellular Component Organization Establishment Of Localization In Cell Retina Development In Camera-type Eye Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Maintenance Of Synapse Structure Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Trophectodermal Cell Proliferation Lysosomal Protein Catabolic Process Positive Regulation Of Aspartic-type Peptidase Activity Regulation Of Lysosome Organization Positive Regulation Of Lysosome Organization	Cell Differentiation Negative Regulation Of Notch Signaling Pathway
Pathways		Neutrophil degranulation	Activated NOTCH1 Transmits Signal to the Nucleus
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Intracranial volume ( 22504418) Mild age-related type 2 diabetes ( 34737425) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Birth weight ( 31043758) Body size at age 10 ( 32376654) Diastolic blood pressure response to thiazide and thiazide-like diuretics in hypertension ( 31754133) Height ( 31562340) Hodgkin's lymphoma ( 34216518) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft palate ( 31609978) Platelet count ( 29403010 22139419) Refractive error ( 32231278) Type 1 diabetes ( 19966805) Type 2 diabetes ( 32499647)
Interacting Genes		88 interacting genes: ALG13 ARFGAP1 ATN1 ATXN7 C22orf39 C4orf17 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CLPP CRCT1 CRKL CRY1 CXCL5 CYSRT1 DLK1 DLX2 DMRT3 ECM1 ELANE FAM131C FAM76B FANCL FRAT1 GFI1B GLRX3 GNE HK3 HOXA1 HSPG2 KRT18 KRT31 KRT34 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP11-1 KRTAP12-1 KRTAP13-2 KRTAP15-1 KRTAP26-1 KRTAP5-9 KRTAP6-1 KRTAP6-2 LCE1A LCE1B LCE1D LCE1E LCE2B LCE2D LCE3C LCE3E LCE4A LCE5A MBD1 MEOX2 NEDD8 NLK NUFIP2 OTX1 P4HB PCM1 PIK3R2 PLLP POT1 POU4F2 PRKAB2 PTPMT1 RAC1 SGTA SHANK3 SLC13A1 SLPI SMAD9 SMCP SNRNP48 SPRY2 TAT TGM2 TLE5 TOP3B TSPAN4 UTP23 VASN YY1	3 interacting genes: GAS1 GRN ZDHHC17
Entrez ID		2896	8788
HPRD ID		00733	01446
Ensembl ID		ENSG00000030582	ENSG00000185559
Uniprot IDs		P28799	A8K019 P80370
PDB IDs		1G26 2JYE 2JYT 2JYU 2JYV 6NUG 8T8R 8T8S
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development P-TEFb Complex Nuclear Matrix Identical Protein Binding	Regulation Of Programmed Cell Death Microglial Cell Activation Involved In Immune Response Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Lysosome Organization Astrocyte Activation Involved In Immune Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Aspartic-type Peptidase Activity Trophectodermal Cell Proliferation Positive Regulation Of Protein Folding Positive Regulation Of Trophectodermal Cell Proliferation Protein-cysteine S-myristoyltransferase Activity Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Respiratory Burst Protein-cysteine S-stearoyltransferase Activity Negative Regulation Of Neutrophil Activation Cerebellar Climbing Fiber To Purkinje Cell Synapse Regulation Of Proteolysis Positive Regulation Of Axon Regeneration Negative Regulation Of Microglial Cell Activation Regulation Of Respiratory Burst Involved In Inflammatory Response Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Protein Folding Regulation Of Neutrophil Activation Positive Regulation Of Peptidase Activity Regulation Of Neurotrophin TRK Receptor Signaling Pathway Oxysterol Binding Lysosomal Protein Catabolic Process Locomotory Exploration Behavior Regulation Of Defense Response To Bacterium Regulation Of Lysosome Organization Macrophage Activation Involved In Immune Response Regulation Of Microglial Cell Activation Positive Regulation Of Defense Response To Bacterium Astrocyte Activation Regulation Of Inflammatory Response To Wounding Protein Catabolic Process In The Vacuole Negative Regulation Of Macrophage Activation Regulation Of Respiratory Burst Negative Regulation Of Neuroinflammatory Response Lipoprotein Transport Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Negative Regulation Of Protein Processing Negative Regulation Of Protein Maturation Lysosomal Lumen Acidification
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