DGKD and SREK1

Number of citations of the paper that reports this interaction (PubMedID 14559993)
73

Data Source:
BioGRID (two hybrid)

		DGKD	SREK1
Description		diacylglycerol kinase delta	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Cytoplasmic Vesicle	Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Nucleic Acid Binding RNA Binding Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Diacylglycerol Catabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis	MRNA Processing RNA Splicing
Pathways		Effects of PIP2 hydrolysis
Drugs		Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bilirubin levels ( 20639394 32084209) Calcium levels ( 20705733 24068962 29403010) Crohn's disease ( 22412388) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926 32499647) Urinary calcium excretion ( 31993563)	Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		10 interacting genes: DGKH DYSF FMR1 FXR2 HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	66 interacting genes: ARL6IP4 CD8A CKAP2 CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 MRPL37 NAT10 NCL NPM1 PABPC1 PABPC4 PARP1 PCBP3 PIN1 PRPF40A RAB5C RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRRM4 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		8527	140890
HPRD ID		03492	18043
Ensembl ID		ENSG00000077044	ENSG00000153914
Uniprot IDs		Q16760	Q8WXA9
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Positive Regulation Of Cell Development Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Intracellular Transport Of Viral Material Positive Regulation Of Myeloid Leukocyte Differentiation Monocyte Activation Involved In Immune Response Dendritic Filopodium Cytoplasmic Ribonucleoprotein Granule Regulation Of Cell Development Regulation Of Neurotransmitter Secretion Signaling Adaptor Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Differentiation Histone H3 Reader Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Adaptive Immune Memory Response SAM Domain Binding Regulation Of Translation Negative Regulation Of Long-term Synaptic Depression Cytoplasmic Stress Granule Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Development Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Protein Kinase C Signaling MRNA Transport MRNA 3'-UTR Binding RNA Strand Annealing Activity Presynaptic Membrane Regulation Of Neuronal Action Potential Regulation Of Angiotensin-activated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Neuronal Ribonucleoprotein Granule Negative Regulation Of Synaptic Vesicle Exocytosis RNA Transport Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Vesicle-mediated Transport	RNA Splicing RNA Binding MRNA Processing MRNA Metabolic Process RNA Processing Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process RNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Binding Regulation Of RNA Splicing RNA Splicing, Via Transesterification Reactions Nucleic Acid Metabolic Process MRNA Splicing, Via Spliceosome Nucleobase-containing Compound Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Binding Nuclear Speck Negative Regulation Of MRNA Metabolic Process Catalytic Step 2 Spliceosome Spliceosomal Complex Ribonucleoprotein Complex Nucleoplasm Nucleus Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process MRNA Stabilization Regulation Of Gene Expression Spliceosomal Complex Assembly Protein-RNA Complex Assembly Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of MRNA Catabolic Process RNA Stabilization Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Catabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Alternative MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Regulation Of Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Gene Expression Pre-mRNA Binding Negative Regulation Of Macromolecule Biosynthetic Process
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