DGKD and HAX1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DGKD	HAX1
Gene Name		diacylglycerol kinase, delta 130kDa	HCLS1 associated protein X-1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Cytoplasmic Membrane-bounded Vesicle	Nuclear Envelope Transcription Factor Complex Mitochondrion Endoplasmic Reticulum Actin Cytoskeleton Apical Plasma Membrane Sarcoplasmic Reticulum Lamellipodium Clathrin-coated Vesicle Nuclear Membrane
	Molecular Function	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Diacylglycerol Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Protein Domain Specific Binding Interleukin-1 Binding Protein N-terminus Binding
	Biological Process	Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Multicellular Organismal Development Blood Coagulation Response To Organic Substance Protein Transport Cell Growth Phosphorylation Second-messenger-mediated Signaling Platelet Activation Diacylglycerol Metabolic Process Protein Homooligomerization	Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Regulation Of Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Kinase B Signaling Cellular Response To Cytokine Stimulus Regulation Of Mitochondrion Degradation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation Effects of PIP2 hydrolysis
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Calcium levels ( 20705733) Crohn's disease ( 22412388)
Protein-Protein Interactions		7 interactors: DGKH HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	23 interactors: ABCB1 ABCB11 ABCB4 BIRC3 CTTN DGKD EIF3F HCLS1 HNF4G IL1A KIAA0513 MAPK10 NEDD4L PKD2 POLR1D PPP3CC RBX1 RPA1 STAT5B SVIL YWHAQ ZNF420 ZNRD1
Entrez ID		8527	10456
HPRD ID		03492	12075
Ensembl ID		ENSG00000077044	ENSG00000143575
Uniprot IDs		Q16760	O00165
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?		Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Leukocyte Differentiation Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Immune System Process Positive Regulation Of Myeloid Cell Differentiation Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Dense Core Granule Biogenesis Wound Healing Regulation Of Myeloid Leukocyte Differentiation Regulation Of Protein Transport Regulation Of Establishment Of Protein Localization Response To Wounding Histone H3-T6 Phosphorylation Response To Cytokine Positive Regulation Of Protein Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Localization Regulation Of Myeloid Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Cytokine Secretion Involved In Immune Response Platelet Activation Positive Regulation Of Protein Modification Process Regulation Of Cellular Localization Regulation Of Protein Phosphorylation Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Plasma Membrane Repair Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Granulocyte Differentiation Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Mitochondrion Degradation Negative Regulation Of Glucose Import Positive Regulation Of Cell Migration Immune Response Positive Regulation Of Cell Motility Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Cellular Component Movement Defense Response Desmosome Organization Positive Regulation Of Locomotion Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway	Positive Regulation Of Organelle Organization Positive Regulation Of Interleukin-2 Production Xenobiotic Transport Response To Abiotic Stimulus Positive Regulation Of Transport DNA-templated Transcription, Initiation Regulation Of Protein Localization Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Gene Expression Positive Regulation Of Signal Transduction Positive Regulation Of Cell Cycle Regulation Of Organelle Organization Intracellular Signal Transduction Regulation Of Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Interleukin-2 Biosynthetic Process Regulation Of Apoptotic Process Response To Stimulus Regulation Of Cellular Localization Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Cytokine Production Regulation Of Establishment Of Protein Localization Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Cell Death Drug Transmembrane Transport Positive Regulation Of Cation Channel Activity Transcription From RNA Polymerase I Promoter Immune System Process Response To Stress Regulation Of Protein Metabolic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Transporter Activity Acute-phase Response Regulation Of Intracellular Transport Positive Regulation Of Innate Immune Response Actin Filament Polymerization Protein Monoubiquitination Positive Regulation Of Intracellular Signal Transduction Drug Transport Signal Transduction Negative Regulation Of Ion Transmembrane Transport Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Ion Transmembrane Transporter Activity Metanephric Cortex Development Metanephric Cortical Collecting Duct Development JAK-STAT Cascade
Tagcloud ?			1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Difference) ?			1222a abolishing aciduria arg408gly atp2a2 atrophy biochemically caseinolytic cataracts cerebellar clpb congenital deleterious disability encephalopathy exome intellectual kostmann methylglutaconic movement neutropenia nonprogressive overlapping peptidase prenatal sanger scn unrelated zebrafish
Tagcloud (Intersection) ?