DGKD and FMR1

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		DGKD	FMR1
Description		diacylglycerol kinase delta	fragile X messenger ribonucleoprotein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Cytoplasmic Vesicle	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Plasma Membrane Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Cell Projection Neuron Projection Dendritic Spine Perikaryon Intracellular Membraneless Organelle Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Growth Cone Filopodium Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	G-quadruplex RNA Binding Nucleic Acid Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding SiRNA Binding MiRNA Binding Signaling Adaptor Activity RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Transmembrane Transporter Binding Protein-containing Complex Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Histone H3 Reader Activity Molecular Condensate Scaffold Activity N6-methyladenosine-containing RNA Reader Activity Sequence-specific MRNA Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Diacylglycerol Catabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Receptor Internalization DNA Repair Chromatin Organization MRNA Processing MRNA Export From Nucleus Regulation Of Translation DNA Damage Response Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Regulation Of Cell Communication Negative Regulation Of Translation Regulatory NcRNA-mediated Gene Silencing Stress Granule Assembly Regulation Of MRNA Stability Host-mediated Perturbation Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion Positive Regulation Of Long-term Neuronal Synaptic Plasticity Animal Organ Development MRNA Transport Positive Regulation Of Cellular Component Organization Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Regulation Of Biological Quality Cellular Response To Virus Regulation Of Neuronal Action Potential Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Membraneless Organelle Assembly Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Cytoplasmic Translation
Pathways		Effects of PIP2 hydrolysis
Drugs		Phosphatidyl serine alpha-Tocopherol succinate
Diseases			Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS		Appendicular lean mass ( 33097823) Bilirubin levels ( 20639394 32084209) Calcium levels ( 20705733 24068962 29403010) Crohn's disease ( 22412388) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926 32499647) Urinary calcium excretion ( 31993563)	Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)
Interacting Genes		10 interacting genes: DGKH DYSF FMR1 FXR2 HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	49 interacting genes: AKAP9 ALDOC ATG5 BEX4 CALCOCO2 CAMK2B CASK CCAR2 CWC25 CYFIP1 CYFIP2 DCTPP1 DGKD EFHC1 FSD2 FXR1 FXR2 GRIP2 H19 HOMER3 INCA1 LIMS1 MAGI3 MEOX1 MVP NCL NECAB2 NUFIP1 NUFIP2 PICK1 POLR1C PPP1R12C PSME3 RANBP9 RBM14 SF3B2 SFPQ SHARPIN SPAG5 STAU1 SUOX TACC2 UBE2I USP7 WEE2-AS1 YBX1 ZBTB42 ZFPM2 ZMYND8
Entrez ID		8527	2332
HPRD ID		03492	02398
Ensembl ID		ENSG00000077044	ENSG00000102081
Uniprot IDs		Q16760	Q06787
PDB IDs		1R79 3BQ7	2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Positive Regulation Of Cell Development Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Intracellular Transport Of Viral Material Positive Regulation Of Myeloid Leukocyte Differentiation Monocyte Activation Involved In Immune Response Dendritic Filopodium Cytoplasmic Ribonucleoprotein Granule Regulation Of Cell Development Regulation Of Neurotransmitter Secretion Signaling Adaptor Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Differentiation Histone H3 Reader Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Adaptive Immune Memory Response SAM Domain Binding Regulation Of Translation Negative Regulation Of Long-term Synaptic Depression Cytoplasmic Stress Granule Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Development Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Protein Kinase C Signaling MRNA Transport MRNA 3'-UTR Binding RNA Strand Annealing Activity Presynaptic Membrane Regulation Of Neuronal Action Potential Regulation Of Angiotensin-activated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Neuronal Ribonucleoprotein Granule Negative Regulation Of Synaptic Vesicle Exocytosis RNA Transport Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Vesicle-mediated Transport	Cytoplasm Modulation Of Chemical Synaptic Transmission Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Metabolic Process Cytosol Negative Regulation Of Protein Metabolic Process Cytoplasmic Stress Granule Synapse Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Perinuclear Region Of Cytoplasm Negative Regulation Of Metabolic Process Neuron Projection Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Cellular Component Organization Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Cytoplasmic Ribonucleoprotein Granule Regulation Of Organelle Organization Negative Regulation Of Biosynthetic Process Cytoskeleton Positive Regulation Of Long-term Neuronal Synaptic Plasticity GMP Kinase Activity Regulation Of Synaptic Plasticity Regulation Of Circadian Rhythm Regulation Of Macromolecule Metabolic Process Dendrite Extension Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Primary Metabolic Process GDP Metabolic Process SCAR Complex Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Deacetylation Microtubule-based Process Regulation Of Signal Transduction Postsynapse Regulation Of Neuronal Synaptic Plasticity Regulation Of Metabolic Process RNA Splicing Positive Regulation Of Organelle Organization Transferase Complex RNA 7-methylguanosine Cap Binding Positive Regulation Of Cellular Component Biogenesis Nuclear Body Nucleoplasm MRNA Binding
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