DGKD and MYH2

Number of citations of the paper that reports this interaction (PubMedID 10082674)
0

Data Source:
HPRD (in vitro)

		DGKD	MYH2
Description		diacylglycerol kinase delta	myosin heavy chain 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit Membrane Cytoplasmic Vesicle	Cytoplasm Cytosol Muscle Myosin Complex Cell-cell Junction Myosin Complex Myosin II Complex Myofibril Sarcomere Myosin Filament Protein-containing Complex Supramolecular Fiber
	Molecular Function	Nucleotide Binding ATP-dependent Diacylglycerol Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding
	Biological Process	Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Protein Transport Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Diacylglycerol Catabolic Process Phosphatidic Acid Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis	Muscle Contraction Muscle Filament Sliding
Pathways		Effects of PIP2 hydrolysis	Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis
Drugs		Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Appendicular lean mass ( 33097823) Bilirubin levels ( 20639394 32084209) Calcium levels ( 20705733 24068962 29403010) Crohn's disease ( 22412388) Femur bone mineral density x serum urate levels interaction ( 34046847) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 30718926 32499647) Urinary calcium excretion ( 31993563)
Interacting Genes		10 interacting genes: DGKH DYSF FMR1 FXR2 HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14	7 interacting genes: AMPD1 DGKD DUX4L9 OBSCN PRKCE PTK2B S100A4
Entrez ID		8527	4620
HPRD ID		03492	01173
Ensembl ID		ENSG00000077044	ENSG00000125414
Uniprot IDs		Q16760	Q9UKX2
PDB IDs		1R79 3BQ7
Enriched GO Terms of Interacting Partners?		Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Positive Regulation Of Cell Development Regulation Of Long-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Regulation Of MRNA Stability Regulation Of RNA Stability Presynaptic Modulation Of Chemical Synaptic Transmission Positive Regulation Of Nervous System Development Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Intracellular Transport Of Viral Material Positive Regulation Of Myeloid Leukocyte Differentiation Monocyte Activation Involved In Immune Response Dendritic Filopodium Cytoplasmic Ribonucleoprotein Granule Regulation Of Cell Development Regulation Of Neurotransmitter Secretion Signaling Adaptor Activity Regulation Of MRNA Metabolic Process Positive Regulation Of Cell Differentiation Histone H3 Reader Activity Positive Regulation Of Dense Core Granule Biogenesis Histone H3T6 Kinase Activity Negative Regulation Of Adaptive Immune Memory Response SAM Domain Binding Regulation Of Translation Negative Regulation Of Long-term Synaptic Depression Cytoplasmic Stress Granule Growth Cone Filopodium Positive Regulation Of Multicellular Organismal Process Regulation Of Nervous System Development Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of Angiotensin-activated Signaling Pathway Alphav-beta3 Integrin-PKCalpha Complex Positive Regulation Of Myeloid Cell Differentiation Regulation Of Myeloid Leukocyte Differentiation Protein Kinase C Signaling MRNA Transport MRNA 3'-UTR Binding RNA Strand Annealing Activity Presynaptic Membrane Regulation Of Neuronal Action Potential Regulation Of Angiotensin-activated Signaling Pathway Granulocyte Colony-stimulating Factor Signaling Pathway Neuronal Ribonucleoprotein Granule Negative Regulation Of Synaptic Vesicle Exocytosis RNA Transport Host-mediated Perturbation Of Viral RNA Genome Replication Regulation Of Vesicle-mediated Transport	Signaling Receptor Activator Activity Kinase Activity AMP Deaminase Activity Phosphate-containing Compound Metabolic Process ATP Binding Positive Regulation Of Protein Polymerization Regulation Of Actin Filament Polymerization Neurotransmitter Receptor Regulator Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of B Cell Chemotaxis Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Monoatomic Ion Transport Phosphorylation Protein Kinase Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell-substrate Adhesion TRAM-dependent Toll-like Receptor 4 Signaling Pathway Ethanol Binding Negative Regulation Of Phospholipase C/protein Kinase C Signal Transduction Positive Regulation Of Clathrin-dependent Endocytosis Protein Localization To M-band Regulation Of Actin Polymerization Or Depolymerization Regulation Of Calcium Ion Transmembrane Transport Cell Activation Involved In Immune Response Regulation Of Actin Filament Length Leukocyte Activation Involved In Immune Response Positive Regulation Of Synaptic Transmission Cell Activation Activation Of Janus Kinase Activity Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Toxin Catabolic Process IMP Salvage GMP Salvage Perinuclear Region Of Cytoplasm Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Signal Transduction Positive Regulation Of Mucus Secretion Positive Regulation Of Cytoskeleton Organization Diacylglycerol Catabolic Process Deaminase Activity NMDA Selective Glutamate Receptor Complex Transferase Activity Signal Complex Assembly Positive Regulation Of Cell Communication Regulation Of Signal Transduction Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Signaling Regulation Of Cell-substrate Adhesion Regulation Of Calcium Ion Transport
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